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Effects of catecholamine depletion on alertness and mood in rested and sleep deprived normal volunteers.
Neuropsychopharmacology 1993; 8(4):345-56N

Abstract

Alpha-methyl-para-tyrosine (AMPT), a tyrosine hydroxylase inhibitor, was used to evaluate the physiologic role of central nervous system catecholamines in modulating alertness and mood. Forty healthy males were randomized to one of four conditions: AMPT in a rested condition; AMPT plus 40.5 hours of total sleep deprivation; placebo plus sleep deprivation; or placebo in a rested condition. Repeated measures of alertness and mood revealed that treatment with AMPT or sleep deprivation increased sleepiness, and combined treatment produced greater sleepiness than either treatment alone. In contrast, although combined treatment with AMPT and sleep deprivation led to large increases in negative mood, neither treatment alone produced consistent mood changes. These findings are consistent with the view that sleep deprivation is associated with decreased functional catecholamine neurotransmission. Furthermore, mood effects following sleep deprivation plus AMPT suggest that catecholamines may be involved in mood changes during sleep deprivation.

Authors+Show Affiliations

Department of Behavioral Biology, Walter Reed Army Institute of Research, Washington, DC.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

8099791

Citation

McCann, U D., et al. "Effects of Catecholamine Depletion On Alertness and Mood in Rested and Sleep Deprived Normal Volunteers." Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, vol. 8, no. 4, 1993, pp. 345-56.
McCann UD, Penetar DM, Shaham Y, et al. Effects of catecholamine depletion on alertness and mood in rested and sleep deprived normal volunteers. Neuropsychopharmacology. 1993;8(4):345-56.
McCann, U. D., Penetar, D. M., Shaham, Y., Thorne, D. R., Sing, H. C., Thomas, M. L., ... Belenky, G. (1993). Effects of catecholamine depletion on alertness and mood in rested and sleep deprived normal volunteers. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 8(4), pp. 345-56.
McCann UD, et al. Effects of Catecholamine Depletion On Alertness and Mood in Rested and Sleep Deprived Normal Volunteers. Neuropsychopharmacology. 1993;8(4):345-56. PubMed PMID: 8099791.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of catecholamine depletion on alertness and mood in rested and sleep deprived normal volunteers. AU - McCann,U D, AU - Penetar,D M, AU - Shaham,Y, AU - Thorne,D R, AU - Sing,H C, AU - Thomas,M L, AU - Gillin,J C, AU - Belenky,G, PY - 1993/6/1/pubmed PY - 1993/6/1/medline PY - 1993/6/1/entrez SP - 345 EP - 56 JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology JO - Neuropsychopharmacology VL - 8 IS - 4 N2 - Alpha-methyl-para-tyrosine (AMPT), a tyrosine hydroxylase inhibitor, was used to evaluate the physiologic role of central nervous system catecholamines in modulating alertness and mood. Forty healthy males were randomized to one of four conditions: AMPT in a rested condition; AMPT plus 40.5 hours of total sleep deprivation; placebo plus sleep deprivation; or placebo in a rested condition. Repeated measures of alertness and mood revealed that treatment with AMPT or sleep deprivation increased sleepiness, and combined treatment produced greater sleepiness than either treatment alone. In contrast, although combined treatment with AMPT and sleep deprivation led to large increases in negative mood, neither treatment alone produced consistent mood changes. These findings are consistent with the view that sleep deprivation is associated with decreased functional catecholamine neurotransmission. Furthermore, mood effects following sleep deprivation plus AMPT suggest that catecholamines may be involved in mood changes during sleep deprivation. SN - 0893-133X UR - https://www.unboundmedicine.com/medline/citation/8099791/Effects_of_catecholamine_depletion_on_alertness_and_mood_in_rested_and_sleep_deprived_normal_volunteers_ L2 - http://dx.doi.org/10.1038/npp.1993.34 DB - PRIME DP - Unbound Medicine ER -