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Evidence that the parafascicular projection to the subthalamic nucleus is glutamatergic.
Neuroreport. 1993 Jun; 4(6):613-5.N

Abstract

The parafascicular nucleus projection to the subthalamic neurones has an excitatory synaptic effect. We have examined the possible glutamatergic mediation of this pathway. The initial excitatory response elicited by electrical stimulation of the parafascicular neurones was inhibited by a microinjection of excitatory amino acid receptor antagonists into the subthalamic nucleus. The antagonists were the broad spectrum kynurenic acid, the NMDA selective antagonist d-AP-5 and the AMPA antagonist CNQX. Their effects were dose-dependent and reversible. The results suggest that the excitatory effect of the parafascicular neurones is mediated by AMPA and NMDA receptors.

Authors+Show Affiliations

Laboratoire de Pharmacologie, Faculté des Sciences Pharmaceutiques et Biologiques, Université R. Descartes, Paris, France.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8102257

Citation

Mouroux, M, and J Féger. "Evidence That the Parafascicular Projection to the Subthalamic Nucleus Is Glutamatergic." Neuroreport, vol. 4, no. 6, 1993, pp. 613-5.
Mouroux M, Féger J. Evidence that the parafascicular projection to the subthalamic nucleus is glutamatergic. Neuroreport. 1993;4(6):613-5.
Mouroux, M., & Féger, J. (1993). Evidence that the parafascicular projection to the subthalamic nucleus is glutamatergic. Neuroreport, 4(6), 613-5.
Mouroux M, Féger J. Evidence That the Parafascicular Projection to the Subthalamic Nucleus Is Glutamatergic. Neuroreport. 1993;4(6):613-5. PubMed PMID: 8102257.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evidence that the parafascicular projection to the subthalamic nucleus is glutamatergic. AU - Mouroux,M, AU - Féger,J, PY - 1993/6/1/pubmed PY - 1993/6/1/medline PY - 1993/6/1/entrez SP - 613 EP - 5 JF - Neuroreport JO - Neuroreport VL - 4 IS - 6 N2 - The parafascicular nucleus projection to the subthalamic neurones has an excitatory synaptic effect. We have examined the possible glutamatergic mediation of this pathway. The initial excitatory response elicited by electrical stimulation of the parafascicular neurones was inhibited by a microinjection of excitatory amino acid receptor antagonists into the subthalamic nucleus. The antagonists were the broad spectrum kynurenic acid, the NMDA selective antagonist d-AP-5 and the AMPA antagonist CNQX. Their effects were dose-dependent and reversible. The results suggest that the excitatory effect of the parafascicular neurones is mediated by AMPA and NMDA receptors. SN - 0959-4965 UR - https://www.unboundmedicine.com/medline/citation/8102257/Evidence_that_the_parafascicular_projection_to_the_subthalamic_nucleus_is_glutamatergic_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=8102257.ui DB - PRIME DP - Unbound Medicine ER -