Tags

Type your tag names separated by a space and hit enter

Modulation by isoproterenol and propranolol of somatostatin receptors in synaptosomes from rat frontoparietal cortex.
Brain Res. 1993 Jun 18; 614(1-2):171-7.BR

Abstract

DL-Propranolol (PRO), a beta-adrenergic blocking agent, and the neuropeptide somatostatin (SS) have central nervous system depressant and anticonvulsive properties. To investigate a possible relationship between these two components, we studied the influence of PRO and DL-isoproterenol (ISO), a beta-adrenergic agonist, on the somatostatinergic system in the rat frontoparietal cortex. The short- (5 h) and long-term (14 days) administration of ISO (5 mg/kg, intraperitoneally (i.p.)), or of PRO (10 mg/kg, i.p.) did not affect somatostatin-like immunoreactivity (SLI) content in the frontoparietal cortex of male Wistar rats. Both short- and long-term ISO administration decreased the number of specific [125I]Tyr11-SS receptors in synaptosomes from frontoparietal cortex (31%, P < 0.05, and 26%, P < 0.02, after short- and long-term administration, respectively) without changing the affinity constant. This decrease in the number of [125I]Tyr11-SS receptors was not due to a direct effect of ISO on these receptors since no decrease in binding was produced by high concentrations of ISO (10(-5) M) when added in vitro. This decrease could be blocked by pretreatment with PRO. Short- and long-term administration of PRO alone produced an increase in the [125I]Tyr11-SS binding in frontoparietal cortex (26%, P < 0.02, and 40%, P < 0.001, after short- or long-term administration, respectively) without changing the affinity constant.

Links

Publisher Full Text

Authors+Show Affiliations

López-Sañudo S
Department of Biochemistry and Molecular Biology, Medical School, University of Alcalá, Madrid, Spain.
Arilla E
No affiliation info available

MeSH

AnimalsFrontal LobeIn Vitro TechniquesIsoproterenolMaleParietal LobePropranololRadioimmunoassayRatsRats, WistarReceptors, SomatostatinSomatostatinSynaptosomes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8102312

Citation

López-Sañudo, S, and E Arilla. "Modulation By Isoproterenol and Propranolol of Somatostatin Receptors in Synaptosomes From Rat Frontoparietal Cortex." Brain Research, vol. 614, no. 1-2, 1993, pp. 171-7.
López-Sañudo S, Arilla E. Modulation by isoproterenol and propranolol of somatostatin receptors in synaptosomes from rat frontoparietal cortex. Brain Res. 1993;614(1-2):171-7.
López-Sañudo, S., & Arilla, E. (1993). Modulation by isoproterenol and propranolol of somatostatin receptors in synaptosomes from rat frontoparietal cortex. Brain Research, 614(1-2), 171-7.
López-Sañudo S, Arilla E. Modulation By Isoproterenol and Propranolol of Somatostatin Receptors in Synaptosomes From Rat Frontoparietal Cortex. Brain Res. 1993 Jun 18;614(1-2):171-7. PubMed PMID: 8102312.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modulation by isoproterenol and propranolol of somatostatin receptors in synaptosomes from rat frontoparietal cortex. AU - López-Sañudo,S, AU - Arilla,E, PY - 1993/6/18/pubmed PY - 1993/6/18/medline PY - 1993/6/18/entrez SP - 171 EP - 7 JF - Brain research JO - Brain Res VL - 614 IS - 1-2 N2 - DL-Propranolol (PRO), a beta-adrenergic blocking agent, and the neuropeptide somatostatin (SS) have central nervous system depressant and anticonvulsive properties. To investigate a possible relationship between these two components, we studied the influence of PRO and DL-isoproterenol (ISO), a beta-adrenergic agonist, on the somatostatinergic system in the rat frontoparietal cortex. The short- (5 h) and long-term (14 days) administration of ISO (5 mg/kg, intraperitoneally (i.p.)), or of PRO (10 mg/kg, i.p.) did not affect somatostatin-like immunoreactivity (SLI) content in the frontoparietal cortex of male Wistar rats. Both short- and long-term ISO administration decreased the number of specific [125I]Tyr11-SS receptors in synaptosomes from frontoparietal cortex (31%, P < 0.05, and 26%, P < 0.02, after short- and long-term administration, respectively) without changing the affinity constant. This decrease in the number of [125I]Tyr11-SS receptors was not due to a direct effect of ISO on these receptors since no decrease in binding was produced by high concentrations of ISO (10(-5) M) when added in vitro. This decrease could be blocked by pretreatment with PRO. Short- and long-term administration of PRO alone produced an increase in the [125I]Tyr11-SS binding in frontoparietal cortex (26%, P < 0.02, and 40%, P < 0.001, after short- or long-term administration, respectively) without changing the affinity constant. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/8102312/Modulation_by_isoproterenol_and_propranolol_of_somatostatin_receptors_in_synaptosomes_from_rat_frontoparietal_cortex_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0006-8993(93)91031-M DB - PRIME DP - Unbound Medicine ER -