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[The metabolism of monosaccharides and polyoles].
Infusionsther Klin Ernahr. 1975 Jun; 2(3):187-201.IK

Abstract

The metabolism and the various metabolic effects of the sugar substitutes fructose, sorbitol and xylitol have been studied and compared to those of glucose. Fructose, sorbitol, and xylitol were found to be metabolized almost completely in the liver, whereas glucose was metabolized only 20-30% by this organ. The sugars and polyols exhibit a number of common effects characteristic of carbohydrate metabolism. Some of them are for example increase in lactate concentration, increase in lactate-pyruvate ratio, decrease in the concentration of free fatty acids, and decrease in phosphate concentration. The only effect that is restricted to fructose, sorbitol, and xylitol, is the stimulation of uric acid biosynthesis. Though sugar substitutes may be regarded as precursors of glucose, they have only little effect on the increase of blood glucose concentration in normal subjects. This may be due to the glucose - fatty acid cycle. It is to be expected that the use of fructose, sorbitol, and xylitol in diabetes mellitus and under stress situations has certain advantages over glucose.

Authors

No affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

ger

PubMed ID

810429

Citation

Förster, H. "[The Metabolism of Monosaccharides and Polyoles]." Infusionstherapie Und Klinische Ernahrung, vol. 2, no. 3, 1975, pp. 187-201.
Förster H. [The metabolism of monosaccharides and polyoles]. Infusionsther Klin Ernahr. 1975;2(3):187-201.
Förster, H. (1975). [The metabolism of monosaccharides and polyoles]. Infusionstherapie Und Klinische Ernahrung, 2(3), 187-201.
Förster H. [The Metabolism of Monosaccharides and Polyoles]. Infusionsther Klin Ernahr. 1975;2(3):187-201. PubMed PMID: 810429.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The metabolism of monosaccharides and polyoles]. A1 - Förster,H, PY - 1975/6/1/pubmed PY - 1975/6/1/medline PY - 1975/6/1/entrez SP - 187 EP - 201 JF - Infusionstherapie und klinische Ernahrung JO - Infusionsther Klin Ernahr VL - 2 IS - 3 N2 - The metabolism and the various metabolic effects of the sugar substitutes fructose, sorbitol and xylitol have been studied and compared to those of glucose. Fructose, sorbitol, and xylitol were found to be metabolized almost completely in the liver, whereas glucose was metabolized only 20-30% by this organ. The sugars and polyols exhibit a number of common effects characteristic of carbohydrate metabolism. Some of them are for example increase in lactate concentration, increase in lactate-pyruvate ratio, decrease in the concentration of free fatty acids, and decrease in phosphate concentration. The only effect that is restricted to fructose, sorbitol, and xylitol, is the stimulation of uric acid biosynthesis. Though sugar substitutes may be regarded as precursors of glucose, they have only little effect on the increase of blood glucose concentration in normal subjects. This may be due to the glucose - fatty acid cycle. It is to be expected that the use of fructose, sorbitol, and xylitol in diabetes mellitus and under stress situations has certain advantages over glucose. SN - 0378-0791 UR - https://www.unboundmedicine.com/medline/citation/810429/[The_metabolism_of_monosaccharides_and_polyoles]_ DB - PRIME DP - Unbound Medicine ER -