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Metabolic effects of graded glucagon infusions in man: inhibition of glucagon, insulin, and somatostatin response to arginine.
Metabolism. 1993 Oct; 42(10):1242-8.M

Abstract

Insulin inhibits its own release (autofeedback), and growth hormone (GH) inhibits the GH response to a variety of stimuli. The aim of this study was to evaluate whether glucagon (G) can modify pancreatic G (IRG) release in humans. Seven healthy men received intravenous (i.v.) arginine (30 g in 30 minutes) 240 minutes after the beginning of a 0.9% NaCI saline infusion and a 2.5-, 4.0-, and 8.0-ng/kg.min-1 porcine G infusion, with each infusion lasting 360 minutes. All G infusions yielded stable and dose-related plasma IRG levels, and the 4.0- and 8.0-ng/kg.min-1 G infusions decreased plasma free fatty acids (FFA) and blood glycerol and beta-OH-butyrate levels and elicited insulin (IRI) release, and the 8.0-ng/kg.min-1 G infusion elicited GH release and increased blood glucose (BG) levels; somatostatin (SRIF) levels were not affected by G infusions. At 240 minutes, plasma IRG levels were higher during G infusion than during saline infusion, whereas serum IRI and BG levels had returned to preinfusion levels. At this point, G infusions decreased the integrated (240 to 300 minutes) IRG, IRI, BG, and SRIF responses, but not the GH response to arginine. These data indicate that prolonged G infusions decrease the IRG response to arginine; in addition, G decreases plasma FFA levels, and higher G doses stimulate IRI release and exert a self-limited hyperglycemic effect. The fact that the IRI response to arginine was decreased by G could be due to a refractoriness of beta cells to subsequent stimuli; the decreased SRIF response to arginine is likely due to G itself or to a decrease of plasma FFA levels.

Authors+Show Affiliations

Istituto Scientifico San Raffaele, Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8105365

Citation

Pontiroli, A E., et al. "Metabolic Effects of Graded Glucagon Infusions in Man: Inhibition of Glucagon, Insulin, and Somatostatin Response to Arginine." Metabolism: Clinical and Experimental, vol. 42, no. 10, 1993, pp. 1242-8.
Pontiroli AE, Perfetti MG, Andreotti AC, et al. Metabolic effects of graded glucagon infusions in man: inhibition of glucagon, insulin, and somatostatin response to arginine. Metabolism. 1993;42(10):1242-8.
Pontiroli, A. E., Perfetti, M. G., Andreotti, A. C., Fattor, B., Monti, L. D., & Pozza, G. (1993). Metabolic effects of graded glucagon infusions in man: inhibition of glucagon, insulin, and somatostatin response to arginine. Metabolism: Clinical and Experimental, 42(10), 1242-8.
Pontiroli AE, et al. Metabolic Effects of Graded Glucagon Infusions in Man: Inhibition of Glucagon, Insulin, and Somatostatin Response to Arginine. Metabolism. 1993;42(10):1242-8. PubMed PMID: 8105365.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic effects of graded glucagon infusions in man: inhibition of glucagon, insulin, and somatostatin response to arginine. AU - Pontiroli,A E, AU - Perfetti,M G, AU - Andreotti,A C, AU - Fattor,B, AU - Monti,L D, AU - Pozza,G, PY - 1993/10/1/pubmed PY - 1993/10/1/medline PY - 1993/10/1/entrez SP - 1242 EP - 8 JF - Metabolism: clinical and experimental JO - Metabolism VL - 42 IS - 10 N2 - Insulin inhibits its own release (autofeedback), and growth hormone (GH) inhibits the GH response to a variety of stimuli. The aim of this study was to evaluate whether glucagon (G) can modify pancreatic G (IRG) release in humans. Seven healthy men received intravenous (i.v.) arginine (30 g in 30 minutes) 240 minutes after the beginning of a 0.9% NaCI saline infusion and a 2.5-, 4.0-, and 8.0-ng/kg.min-1 porcine G infusion, with each infusion lasting 360 minutes. All G infusions yielded stable and dose-related plasma IRG levels, and the 4.0- and 8.0-ng/kg.min-1 G infusions decreased plasma free fatty acids (FFA) and blood glycerol and beta-OH-butyrate levels and elicited insulin (IRI) release, and the 8.0-ng/kg.min-1 G infusion elicited GH release and increased blood glucose (BG) levels; somatostatin (SRIF) levels were not affected by G infusions. At 240 minutes, plasma IRG levels were higher during G infusion than during saline infusion, whereas serum IRI and BG levels had returned to preinfusion levels. At this point, G infusions decreased the integrated (240 to 300 minutes) IRG, IRI, BG, and SRIF responses, but not the GH response to arginine. These data indicate that prolonged G infusions decrease the IRG response to arginine; in addition, G decreases plasma FFA levels, and higher G doses stimulate IRI release and exert a self-limited hyperglycemic effect. The fact that the IRI response to arginine was decreased by G could be due to a refractoriness of beta cells to subsequent stimuli; the decreased SRIF response to arginine is likely due to G itself or to a decrease of plasma FFA levels. SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/8105365/Metabolic_effects_of_graded_glucagon_infusions_in_man:_inhibition_of_glucagon_insulin_and_somatostatin_response_to_arginine_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0026-0495(93)90120-D DB - PRIME DP - Unbound Medicine ER -