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Role of nucleosides and nucleotide mixture in intestinal mucosal growth under total parenteral nutrition.
Nutrition. 1993 Nov-Dec; 9(6):532-5.N

Abstract

The preventive effect of a mixture of nucleosides and a nucleotide (OG-VI) on total parenteral nutrition (TPN)-associated gut mucosal atrophy was investigated. Male Wistar rats were randomly divided into two groups. The TPN group (n = 11) received a standard TPN diet (250 kcal and 1.78 g nitrogen.kg-1.day-1) for 6 days; the TPN + OG-VI group (n = 10) received OG-VI (2.5 ml.kg-1.day-1) in addition to the standard TPN solution for 6 days. To obtain information on a normal fed condition of the intestine, another 10 rats were maintained on oral rat chow for 6 days. Compared with the TPN group, mucosal wet weights in the jejunum (22.8 +/- 1.8 vs. 20.5 +/- 2.0 mg/cm) and the ileum (19.4 +/- 2.2 vs. 16.8 +/- 2.3 mg/cm) were significantly greater in the TPN + OG-VI group. Likewise, diamine oxidase activities in the jejunum (13.7 +/- 4.27 vs. 8.02 +/- 3.40 nmol.min-1.cm-1) and the ileum (33.9 +/- 6.89 vs. 25.9 +/- 7.93 nmol.min-1.cm-1) were significantly higher in the TPN + OG-VI group. Moreover, the bromodeoxyuridine labeling index in the TPN + OG-VI group (36.9 +/- 4.30%) was significantly higher than in the TPN group (31.0 +/- 3.03%). The addition of OG-VI to the standard TPN diet improved mucosal growth and maturity by increasing the proliferating activity of crypt cells. External provision of purines and pyrimidines may be necessary to sustain mucosal function during TPN.

Authors+Show Affiliations

Department of Surgery II, Osaka University Medical School, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8111144

Citation

Tsujinaka, T, et al. "Role of Nucleosides and Nucleotide Mixture in Intestinal Mucosal Growth Under Total Parenteral Nutrition." Nutrition (Burbank, Los Angeles County, Calif.), vol. 9, no. 6, 1993, pp. 532-5.
Tsujinaka T, Iijima S, Kido Y, et al. Role of nucleosides and nucleotide mixture in intestinal mucosal growth under total parenteral nutrition. Nutrition. 1993;9(6):532-5.
Tsujinaka, T., Iijima, S., Kido, Y., Homma, T., Ebisui, C., Kan, K., Imamura, I., Fukui, H., & Mori, T. (1993). Role of nucleosides and nucleotide mixture in intestinal mucosal growth under total parenteral nutrition. Nutrition (Burbank, Los Angeles County, Calif.), 9(6), 532-5.
Tsujinaka T, et al. Role of Nucleosides and Nucleotide Mixture in Intestinal Mucosal Growth Under Total Parenteral Nutrition. Nutrition. 1993 Nov-Dec;9(6):532-5. PubMed PMID: 8111144.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of nucleosides and nucleotide mixture in intestinal mucosal growth under total parenteral nutrition. AU - Tsujinaka,T, AU - Iijima,S, AU - Kido,Y, AU - Homma,T, AU - Ebisui,C, AU - Kan,K, AU - Imamura,I, AU - Fukui,H, AU - Mori,T, PY - 1993/11/1/pubmed PY - 1993/11/1/medline PY - 1993/11/1/entrez SP - 532 EP - 5 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 9 IS - 6 N2 - The preventive effect of a mixture of nucleosides and a nucleotide (OG-VI) on total parenteral nutrition (TPN)-associated gut mucosal atrophy was investigated. Male Wistar rats were randomly divided into two groups. The TPN group (n = 11) received a standard TPN diet (250 kcal and 1.78 g nitrogen.kg-1.day-1) for 6 days; the TPN + OG-VI group (n = 10) received OG-VI (2.5 ml.kg-1.day-1) in addition to the standard TPN solution for 6 days. To obtain information on a normal fed condition of the intestine, another 10 rats were maintained on oral rat chow for 6 days. Compared with the TPN group, mucosal wet weights in the jejunum (22.8 +/- 1.8 vs. 20.5 +/- 2.0 mg/cm) and the ileum (19.4 +/- 2.2 vs. 16.8 +/- 2.3 mg/cm) were significantly greater in the TPN + OG-VI group. Likewise, diamine oxidase activities in the jejunum (13.7 +/- 4.27 vs. 8.02 +/- 3.40 nmol.min-1.cm-1) and the ileum (33.9 +/- 6.89 vs. 25.9 +/- 7.93 nmol.min-1.cm-1) were significantly higher in the TPN + OG-VI group. Moreover, the bromodeoxyuridine labeling index in the TPN + OG-VI group (36.9 +/- 4.30%) was significantly higher than in the TPN group (31.0 +/- 3.03%). The addition of OG-VI to the standard TPN diet improved mucosal growth and maturity by increasing the proliferating activity of crypt cells. External provision of purines and pyrimidines may be necessary to sustain mucosal function during TPN. SN - 0899-9007 UR - https://www.unboundmedicine.com/medline/citation/8111144/Role_of_nucleosides_and_nucleotide_mixture_in_intestinal_mucosal_growth_under_total_parenteral_nutrition_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:8111144 DB - PRIME DP - Unbound Medicine ER -