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The efficacy of sucralfate suspension in the prevention of oral mucositis due to radiation therapy.

Abstract

PURPOSE

The purpose of this study was to assess the value of sucralfate suspension in prevention of oral mucositis and for reduction of oral pain in patients who develop mucositis during radiation therapy.

METHODS AND MATERIALS

The study was a double-blind, placebo-controlled, randomized prospective trial of a sucralfate suspension in the prevention and management of oral mucositis during radiation therapy. Oral mucositis was assessed using a quantitative scale and symptoms were assessed using visual analogue scales. The statistical model was developed to detect a 40% reduction in mucositis.

RESULTS

No statistically significant reduction in mucositis was seen. Early during radiation therapy less oral pain was reported in the sucralfate group, but as treatment progressed all patients experienced pain. Patients in the sucralfate group were prescribed topical and systemic analgesics later in the course of radiation therapy.

CONCLUSION

Prophylactic oral rinsing with sucralfate did not prevent oral ulcerative mucositis. Sucralfate may reduce the experience of pain during radiation therapy.

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  • Authors

    ,

    Source

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Canada
    Double-Blind Method
    Female
    Humans
    Male
    Middle Aged
    Mouth Mucosa
    Prospective Studies
    Radiotherapy
    Stomatitis
    Sucralfate
    Suspensions

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    8113113

    Citation

    TY - JOUR T1 - The efficacy of sucralfate suspension in the prevention of oral mucositis due to radiation therapy. AU - Epstein,J B, AU - Wong,F L, PY - 1994/2/1/pubmed PY - 1994/2/1/medline PY - 1994/2/1/entrez SP - 693 EP - 8 JF - International journal of radiation oncology, biology, physics JO - Int. J. Radiat. Oncol. Biol. Phys. VL - 28 IS - 3 N2 - PURPOSE: The purpose of this study was to assess the value of sucralfate suspension in prevention of oral mucositis and for reduction of oral pain in patients who develop mucositis during radiation therapy. METHODS AND MATERIALS: The study was a double-blind, placebo-controlled, randomized prospective trial of a sucralfate suspension in the prevention and management of oral mucositis during radiation therapy. Oral mucositis was assessed using a quantitative scale and symptoms were assessed using visual analogue scales. The statistical model was developed to detect a 40% reduction in mucositis. RESULTS: No statistically significant reduction in mucositis was seen. Early during radiation therapy less oral pain was reported in the sucralfate group, but as treatment progressed all patients experienced pain. Patients in the sucralfate group were prescribed topical and systemic analgesics later in the course of radiation therapy. CONCLUSION: Prophylactic oral rinsing with sucralfate did not prevent oral ulcerative mucositis. Sucralfate may reduce the experience of pain during radiation therapy. SN - 0360-3016 UR - https://www.unboundmedicine.com/medline/citation/8113113/The_efficacy_of_sucralfate_suspension_in_the_prevention_of_oral_mucositis_due_to_radiation_therapy_ L2 - http://linkinghub.elsevier.com/retrieve/pii/0360-3016(94)90195-3 ER -