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The efficacy of sucralfate suspension in the prevention of oral mucositis due to radiation therapy.
PURPOSEThe purpose of this study was to assess the value of sucralfate suspension in prevention of oral mucositis and for reduction of oral pain in patients who develop mucositis during radiation therapy.
METHODS AND MATERIALSThe study was a double-blind, placebo-controlled, randomized prospective trial of a sucralfate suspension in the prevention and management of oral mucositis during radiation therapy. Oral mucositis was assessed using a quantitative scale and symptoms were assessed using visual analogue scales. The statistical model was developed to detect a 40% reduction in mucositis.
RESULTSNo statistically significant reduction in mucositis was seen. Early during radiation therapy less oral pain was reported in the sucralfate group, but as treatment progressed all patients experienced pain. Patients in the sucralfate group were prescribed topical and systemic analgesics later in the course of radiation therapy.
CONCLUSIONProphylactic oral rinsing with sucralfate did not prevent oral ulcerative mucositis. Sucralfate may reduce the experience of pain during radiation therapy.
International journal of radiation oncology, biology, physics 28:3 1994 Feb 1 pg 693-8
Aged, 80 and over
Pub Type(s)Clinical Trial
Randomized Controlled Trial
Research Support, Non-U.S. Gov't