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Discrepancy among dissolution rates of commercial tablets as a function of dissolution method. Part 5: In vitro/in vivo correlation for chlorpromazine hydrochloride tablets.
Pharmazie. 1993 Dec; 48(12):932-5.P

Abstract

The bioavailability of seven commercially available batches of chlorpromazine hydrochloride tablets belonging to three different brands was assessed by measuring the intensity of miotic response to the tablets in six normal human subjects according to a cross-over design system. The following pharmacodynamic parameters were computed, viz., maximum miotic response intensity, tmax, half-peak time as well as the area under the percentage miotic response intensity versus time curve from time 0 to 8 h. Attempts to correlate two in vitro dissolution parameters, that is, dissolution efficiency and percentage weight of drug dissolved after 30 min to the in vivo parameter of the area under percentage miotic response intensity versus time curve revealed that the second in vitro parameter correlates better than the first one with the in vivo parameter regardless of the dissolution method. On the other hand, the two in vitro dissolution parameters obtained by the USP rotating basket method show good correlation with the in vivo parameter.

Authors+Show Affiliations

Department of Pharmaceutical Sciences, National Research Centre, Dokki, Cairo, Egypt.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8115438

Citation

Ammar, H O., et al. "Discrepancy Among Dissolution Rates of Commercial Tablets as a Function of Dissolution Method. Part 5: in Vitro/in Vivo Correlation for Chlorpromazine Hydrochloride Tablets." Die Pharmazie, vol. 48, no. 12, 1993, pp. 932-5.
Ammar HO, Khalil RM, Omar SM. Discrepancy among dissolution rates of commercial tablets as a function of dissolution method. Part 5: In vitro/in vivo correlation for chlorpromazine hydrochloride tablets. Pharmazie. 1993;48(12):932-5.
Ammar, H. O., Khalil, R. M., & Omar, S. M. (1993). Discrepancy among dissolution rates of commercial tablets as a function of dissolution method. Part 5: In vitro/in vivo correlation for chlorpromazine hydrochloride tablets. Die Pharmazie, 48(12), 932-5.
Ammar HO, Khalil RM, Omar SM. Discrepancy Among Dissolution Rates of Commercial Tablets as a Function of Dissolution Method. Part 5: in Vitro/in Vivo Correlation for Chlorpromazine Hydrochloride Tablets. Pharmazie. 1993;48(12):932-5. PubMed PMID: 8115438.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Discrepancy among dissolution rates of commercial tablets as a function of dissolution method. Part 5: In vitro/in vivo correlation for chlorpromazine hydrochloride tablets. AU - Ammar,H O, AU - Khalil,R M, AU - Omar,S M, PY - 1993/12/1/pubmed PY - 1993/12/1/medline PY - 1993/12/1/entrez SP - 932 EP - 5 JF - Die Pharmazie JO - Pharmazie VL - 48 IS - 12 N2 - The bioavailability of seven commercially available batches of chlorpromazine hydrochloride tablets belonging to three different brands was assessed by measuring the intensity of miotic response to the tablets in six normal human subjects according to a cross-over design system. The following pharmacodynamic parameters were computed, viz., maximum miotic response intensity, tmax, half-peak time as well as the area under the percentage miotic response intensity versus time curve from time 0 to 8 h. Attempts to correlate two in vitro dissolution parameters, that is, dissolution efficiency and percentage weight of drug dissolved after 30 min to the in vivo parameter of the area under percentage miotic response intensity versus time curve revealed that the second in vitro parameter correlates better than the first one with the in vivo parameter regardless of the dissolution method. On the other hand, the two in vitro dissolution parameters obtained by the USP rotating basket method show good correlation with the in vivo parameter. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/8115438/Discrepancy_among_dissolution_rates_of_commercial_tablets_as_a_function_of_dissolution_method__Part_5:_In_vitro/in_vivo_correlation_for_chlorpromazine_hydrochloride_tablets_ DB - PRIME DP - Unbound Medicine ER -