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Prolonged stabilization of multiple and single brain metastases from breast cancer with tamoxifen. Report of three cases.

Abstract

Cancer frequently metastasizes to the brain, and such lesions, whether multiple or solitary, have a poor prognosis, despite all efforts to treat them. There have been recent sporadic reports of brain metastases from breast cancer responding for some years to antiestrogens (particularly tamoxifen) or bromocriptine. We report three cases of brain metastasis from cancer--two multiple and one a solitary lesion. The long survival of the patients--two for 5 years and one for 6 years, with more than an acceptable quality of life - should prompt therapeutic trials to test tamoxifen and designed to assess its effects on a sizable number of patients.

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  • Authors+Show Affiliations

    ,

    Department of Neurological Sciences-Neurosurgery, La Sapienza University of Rome, Italy.

    , ,

    Source

    Tumori 79:5 1993 Oct 31 pg 359-62

    MeSH

    Aged
    Brain Neoplasms
    Breast Neoplasms
    Female
    Humans
    Middle Aged
    Tamoxifen

    Pub Type(s)

    Case Reports
    Journal Article

    Language

    eng

    PubMed ID

    8116083

    Citation

    TY - JOUR T1 - Prolonged stabilization of multiple and single brain metastases from breast cancer with tamoxifen. Report of three cases. AU - Salvati,M, AU - Cervoni,L, AU - Innocenzi,G, AU - Bardella,L, PY - 1993/10/31/pubmed PY - 1993/10/31/medline PY - 1993/10/31/entrez SP - 359 EP - 62 JF - Tumori JO - Tumori VL - 79 IS - 5 N2 - Cancer frequently metastasizes to the brain, and such lesions, whether multiple or solitary, have a poor prognosis, despite all efforts to treat them. There have been recent sporadic reports of brain metastases from breast cancer responding for some years to antiestrogens (particularly tamoxifen) or bromocriptine. We report three cases of brain metastasis from cancer--two multiple and one a solitary lesion. The long survival of the patients--two for 5 years and one for 6 years, with more than an acceptable quality of life - should prompt therapeutic trials to test tamoxifen and designed to assess its effects on a sizable number of patients. SN - 0300-8916 UR - https://www.unboundmedicine.com/medline/citation/8116083/full_citation/Prolonged_stabilization_of_multiple_and_single_brain_metastases_from_breast_cancer_with_tamoxifen__Report_of_three_cases_ L2 - http://www.diseaseinfosearch.org/result/960 ER -