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Intractable hiccups and sleep apnea syndrome in multiple sclerosis: report of two cases.
Acta Neurol Scand. 1993 Dec; 88(6):401-5.AN

Abstract

Two cases of multiple sclerosis associated with intractable hiccups (IH) and sleep apnea syndrome (SAS) are reported. Lesions were detected in the tegmentum of the medulla oblongata by magnetic resonance imaging. In one case, high dose methylprednisolone was remarkably effective for the IH. For the SAS, amitriptyline was effective in one case. The IH and SAS are thought to be important symptoms when a lesion occurs in the tegmentum of the medulla oblongata, including the paramedian and lateral reticular formations. If IH appears in conjunction with a lesion in the tegmentum of the medulla oblongata, one must be vigilant for the development of SAS.

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Authors+Show Affiliations

Funakawa I
Department of Internal Medicine, Kawasaki Medical School, Japan.
Hara K
No affiliation info available
Yasuda T
No affiliation info available
Terao A
No affiliation info available

MeSH

AmitriptylineFemaleHiccupHumansMagnetic Resonance ImagingMaleMedulla OblongataMethylprednisoloneMiddle AgedMultiple SclerosisRadiographySleep Apnea Syndromes

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

8116339

Citation

Funakawa, I, et al. "Intractable Hiccups and Sleep Apnea Syndrome in Multiple Sclerosis: Report of Two Cases." Acta Neurologica Scandinavica, vol. 88, no. 6, 1993, pp. 401-5.
Funakawa I, Hara K, Yasuda T, et al. Intractable hiccups and sleep apnea syndrome in multiple sclerosis: report of two cases. Acta Neurol Scand. 1993;88(6):401-5.
Funakawa, I., Hara, K., Yasuda, T., & Terao, A. (1993). Intractable hiccups and sleep apnea syndrome in multiple sclerosis: report of two cases. Acta Neurologica Scandinavica, 88(6), 401-5.
Funakawa I, et al. Intractable Hiccups and Sleep Apnea Syndrome in Multiple Sclerosis: Report of Two Cases. Acta Neurol Scand. 1993;88(6):401-5. PubMed PMID: 8116339.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intractable hiccups and sleep apnea syndrome in multiple sclerosis: report of two cases. AU - Funakawa,I, AU - Hara,K, AU - Yasuda,T, AU - Terao,A, PY - 1993/12/1/pubmed PY - 1993/12/1/medline PY - 1993/12/1/entrez SP - 401 EP - 5 JF - Acta neurologica Scandinavica JO - Acta Neurol Scand VL - 88 IS - 6 N2 - Two cases of multiple sclerosis associated with intractable hiccups (IH) and sleep apnea syndrome (SAS) are reported. Lesions were detected in the tegmentum of the medulla oblongata by magnetic resonance imaging. In one case, high dose methylprednisolone was remarkably effective for the IH. For the SAS, amitriptyline was effective in one case. The IH and SAS are thought to be important symptoms when a lesion occurs in the tegmentum of the medulla oblongata, including the paramedian and lateral reticular formations. If IH appears in conjunction with a lesion in the tegmentum of the medulla oblongata, one must be vigilant for the development of SAS. SN - 0001-6314 UR - https://www.unboundmedicine.com/medline/citation/8116339/Intractable_hiccups_and_sleep_apnea_syndrome_in_multiple_sclerosis:_report_of_two_cases_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0001-6314&date=1993&volume=88&issue=6&spage=401 DB - PRIME DP - Unbound Medicine ER -