Tags

Type your tag names separated by a space and hit enter

Oral contraceptive tablets containing 20 and 30 micrograms of ethinyl estradiol with 150 micrograms desogestrel. Their influence on lipids, lipoproteins, sex hormone binding globulin and testosterone.
Acta Obstet Gynecol Scand 1994; 73(2):136-43AO

Abstract

The effect of two oral contraceptive (OC) pills, both containing 150 micrograms of desogestrel, but with 20 (Mercilon) or 30 micrograms (Marvelon/Desolett) of ethinyl estradiol on plasma levels of lipids, lipoproteins and sex hormone binding globulin (SHBG), total and free testosterone were compared in a double-blind, randomized, two-center study in a total of 60 women over one year. A significant rise with Marvelon but not with Mercilon was seen in total cholesterol, HDL cholesterol, HDL-3 and apolipoprotein B, whereas LDL cholesterol decreased with Mercilon only. These effects resulted in significant differences between the two groups in the magnitude of responses in all these parameters except HDL-3. HDL-2, apolipoprotein A-1 and total phospholipids were elevated with both pills after treatment and with no difference in the degree of response between groups. The HDL/LDL cholesterol ratio tended to increase in both groups and that of apolipoproteins A-1/B in the women on Mercilon. Total triglycerides increased in both groups, but more in the women on Marvelon. Total testosterone decreased, particularly in the Marvelon group, whereas the two pills caused a similar increase in SHBG and decrease in free testosterone. It is concluded that the direction of changes in plasma lipids and lipoproteins with both these pills may as a whole be interpreted as beneficial, and that the differences in effect on LDL cholesterol and apolipoprotein B may suggest a slightly advantageous effect of Mercilon in this aspect. However, the clinical significance of these changes is uncertain. The results indicate a lack of androgenicity of both pills.

Authors+Show Affiliations

Student Gynecology Clinic in Lund, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

8116352

Citation

Akerlund, M, et al. "Oral Contraceptive Tablets Containing 20 and 30 Micrograms of Ethinyl Estradiol With 150 Micrograms Desogestrel. Their Influence On Lipids, Lipoproteins, Sex Hormone Binding Globulin and Testosterone." Acta Obstetricia Et Gynecologica Scandinavica, vol. 73, no. 2, 1994, pp. 136-43.
Akerlund M, Almström E, Högstedt S, et al. Oral contraceptive tablets containing 20 and 30 micrograms of ethinyl estradiol with 150 micrograms desogestrel. Their influence on lipids, lipoproteins, sex hormone binding globulin and testosterone. Acta Obstet Gynecol Scand. 1994;73(2):136-43.
Akerlund, M., Almström, E., Högstedt, S., & Nabrink, M. (1994). Oral contraceptive tablets containing 20 and 30 micrograms of ethinyl estradiol with 150 micrograms desogestrel. Their influence on lipids, lipoproteins, sex hormone binding globulin and testosterone. Acta Obstetricia Et Gynecologica Scandinavica, 73(2), pp. 136-43.
Akerlund M, et al. Oral Contraceptive Tablets Containing 20 and 30 Micrograms of Ethinyl Estradiol With 150 Micrograms Desogestrel. Their Influence On Lipids, Lipoproteins, Sex Hormone Binding Globulin and Testosterone. Acta Obstet Gynecol Scand. 1994;73(2):136-43. PubMed PMID: 8116352.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral contraceptive tablets containing 20 and 30 micrograms of ethinyl estradiol with 150 micrograms desogestrel. Their influence on lipids, lipoproteins, sex hormone binding globulin and testosterone. AU - Akerlund,M, AU - Almström,E, AU - Högstedt,S, AU - Nabrink,M, PY - 1994/2/1/pubmed PY - 1994/2/1/medline PY - 1994/2/1/entrez KW - Androgens KW - Biology KW - Case Control Studies KW - Cholesterol KW - Comparative Studies KW - Contraception KW - Contraceptive Agents KW - Contraceptive Agents, Estrogen KW - Contraceptive Agents, Female KW - Contraceptive Agents, Progestin KW - Contraceptive Methods KW - Desogestrel KW - Developed Countries KW - Double-blind Studies KW - Endocrine System KW - Ethinyl Estradiol KW - Europe KW - Family Planning KW - Hormones KW - Lipid Metabolic Effects KW - Lipids KW - Northern Europe KW - Oral Contraceptives KW - Oral Contraceptives, Combined KW - Physiology KW - Research Report KW - Scandinavia KW - Studies KW - Sweden KW - Testosterone SP - 136 EP - 43 JF - Acta obstetricia et gynecologica Scandinavica JO - Acta Obstet Gynecol Scand VL - 73 IS - 2 N2 - The effect of two oral contraceptive (OC) pills, both containing 150 micrograms of desogestrel, but with 20 (Mercilon) or 30 micrograms (Marvelon/Desolett) of ethinyl estradiol on plasma levels of lipids, lipoproteins and sex hormone binding globulin (SHBG), total and free testosterone were compared in a double-blind, randomized, two-center study in a total of 60 women over one year. A significant rise with Marvelon but not with Mercilon was seen in total cholesterol, HDL cholesterol, HDL-3 and apolipoprotein B, whereas LDL cholesterol decreased with Mercilon only. These effects resulted in significant differences between the two groups in the magnitude of responses in all these parameters except HDL-3. HDL-2, apolipoprotein A-1 and total phospholipids were elevated with both pills after treatment and with no difference in the degree of response between groups. The HDL/LDL cholesterol ratio tended to increase in both groups and that of apolipoproteins A-1/B in the women on Mercilon. Total triglycerides increased in both groups, but more in the women on Marvelon. Total testosterone decreased, particularly in the Marvelon group, whereas the two pills caused a similar increase in SHBG and decrease in free testosterone. It is concluded that the direction of changes in plasma lipids and lipoproteins with both these pills may as a whole be interpreted as beneficial, and that the differences in effect on LDL cholesterol and apolipoprotein B may suggest a slightly advantageous effect of Mercilon in this aspect. However, the clinical significance of these changes is uncertain. The results indicate a lack of androgenicity of both pills. SN - 0001-6349 UR - https://www.unboundmedicine.com/medline/citation/8116352/Oral_contraceptive_tablets_containing_20_and_30_micrograms_of_ethinyl_estradiol_with_150_micrograms_desogestrel__Their_influence_on_lipids_lipoproteins_sex_hormone_binding_globulin_and_testosterone_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0001-6349&date=1994&volume=73&issue=2&spage=136 DB - PRIME DP - Unbound Medicine ER -