Tags

Type your tag names separated by a space and hit enter

Aspirin and nonsteroidal anti-inflammatory drug use and the risk of subsequent colorectal cancer.
Arch Intern Med 1994; 154(4):394-9AI

Abstract

OBJECTIVE

To test the hypothesis that the regular use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) is negatively associated with the risk of subsequent colorectal cancer.

DESIGN

Case-control study with four age- and sex-matched control subjects for each incident colorectal cancer case.

POPULATION AND SETTING

Patient population of a large municipal teaching hospital in Atlanta, Ga.

MAIN OUTCOME MEASURE

Odds of colorectal cancer as a function of aspirin, nonaspirin NSAIDs, and acetaminophen dispensed to the study population in the 4 years prior to incident colorectal cancer diagnosis.

MAIN RESULTS

The risk of colorectal cancer estimated by odds ratios decreased with increasing days of exposure to aspirin linearly in a dose-dependent fashion (likelihood ratio statistic: for cumulative days, P < .001; for cumulative dose, P < .001). The coefficient for days of exposure to aspirin was highly significant even when modeled as a continuous variable (P = .001). There appeared to be a threshold above which nonaspirin NSAIDs afforded protection (likelihood ratio statistic: for cumulative days, P = .021; for cumulative dose, P = .019). Acetaminophen conferred no risk reduction.

CONCLUSION

The results of previous experimental animal models, interventional case studies, and some but not all epidemiological investigations and the present data point toward a causal relationship between NSAID use and the prevention of cancer of the large bowel and rectum. Because of the potential gastrointestinal and renal side effects of NSAID use, particularly in the elderly, chemoprevention trials are now needed to allow risk-benefit analysis in populations at high risk for colorectal cancer.

Authors+Show Affiliations

Medical Service, Grady Memorial Hospital, Atlanta, GA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8117171

Citation

Peleg, I I., et al. "Aspirin and Nonsteroidal Anti-inflammatory Drug Use and the Risk of Subsequent Colorectal Cancer." Archives of Internal Medicine, vol. 154, no. 4, 1994, pp. 394-9.
Peleg II, Maibach HT, Brown SH, et al. Aspirin and nonsteroidal anti-inflammatory drug use and the risk of subsequent colorectal cancer. Arch Intern Med. 1994;154(4):394-9.
Peleg, I. I., Maibach, H. T., Brown, S. H., & Wilcox, C. M. (1994). Aspirin and nonsteroidal anti-inflammatory drug use and the risk of subsequent colorectal cancer. Archives of Internal Medicine, 154(4), pp. 394-9.
Peleg II, et al. Aspirin and Nonsteroidal Anti-inflammatory Drug Use and the Risk of Subsequent Colorectal Cancer. Arch Intern Med. 1994 Feb 28;154(4):394-9. PubMed PMID: 8117171.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aspirin and nonsteroidal anti-inflammatory drug use and the risk of subsequent colorectal cancer. AU - Peleg,I I, AU - Maibach,H T, AU - Brown,S H, AU - Wilcox,C M, PY - 1994/2/28/pubmed PY - 1994/2/28/medline PY - 1994/2/28/entrez SP - 394 EP - 9 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 154 IS - 4 N2 - OBJECTIVE: To test the hypothesis that the regular use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) is negatively associated with the risk of subsequent colorectal cancer. DESIGN: Case-control study with four age- and sex-matched control subjects for each incident colorectal cancer case. POPULATION AND SETTING: Patient population of a large municipal teaching hospital in Atlanta, Ga. MAIN OUTCOME MEASURE: Odds of colorectal cancer as a function of aspirin, nonaspirin NSAIDs, and acetaminophen dispensed to the study population in the 4 years prior to incident colorectal cancer diagnosis. MAIN RESULTS: The risk of colorectal cancer estimated by odds ratios decreased with increasing days of exposure to aspirin linearly in a dose-dependent fashion (likelihood ratio statistic: for cumulative days, P < .001; for cumulative dose, P < .001). The coefficient for days of exposure to aspirin was highly significant even when modeled as a continuous variable (P = .001). There appeared to be a threshold above which nonaspirin NSAIDs afforded protection (likelihood ratio statistic: for cumulative days, P = .021; for cumulative dose, P = .019). Acetaminophen conferred no risk reduction. CONCLUSION: The results of previous experimental animal models, interventional case studies, and some but not all epidemiological investigations and the present data point toward a causal relationship between NSAID use and the prevention of cancer of the large bowel and rectum. Because of the potential gastrointestinal and renal side effects of NSAID use, particularly in the elderly, chemoprevention trials are now needed to allow risk-benefit analysis in populations at high risk for colorectal cancer. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/8117171/Aspirin_and_nonsteroidal_anti_inflammatory_drug_use_and_the_risk_of_subsequent_colorectal_cancer_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/vol/154/pg/394 DB - PRIME DP - Unbound Medicine ER -