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Helicobacter pylori infection in early and advanced gastric adenocarcinoma: a seroprevalence study in 143 Taiwanese patients.
Hepatogastroenterology 1993; 40(6):596-9H

Abstract

The association between gastric adenocarcinoma and Helicobacter pylori infection remains controversial. A seroprevalence study of Helicobacter pylori infection in 143 patients with gastric adenocarcinoma and a control group of 823 subjects randomly selected from four areas in Taiwan, was carried out to elucidate the association. The overall seropositivity of Helicobacter pylori in gastric adenocarcinoma patients (62.9%) was higher than in controls (54.4%), but the difference was not statistically significant (p > 0.05). The seropositivity of early gastric adenocarcinoma (61.5%) was not significantly different from that of advanced gastric adenocarcinoma (63.2%). Various demographic factors such as sex, blood type, cigarette smoking, tumor histology and location were not associated with the seroprevalence of Helicobacter pylori. The age-specific seroprevalence of Helicobacter pylori tended to be higher in younger patients and decreased after the age of 60 years in gastric adenocarcinoma, in contrast to a stepwise increase of seropositivity in controls. This suggests that Helicobacter pylori infection in early life may be a contributory factor in gastric carcinogenesis.

Authors+Show Affiliations

Department of Internal Medicine, National Taiwan University College of Medicine, Taipei.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8119647

Citation

Lin, J T., et al. "Helicobacter Pylori Infection in Early and Advanced Gastric Adenocarcinoma: a Seroprevalence Study in 143 Taiwanese Patients." Hepato-gastroenterology, vol. 40, no. 6, 1993, pp. 596-9.
Lin JT, Wang JT, Wang TH, et al. Helicobacter pylori infection in early and advanced gastric adenocarcinoma: a seroprevalence study in 143 Taiwanese patients. Hepatogastroenterology. 1993;40(6):596-9.
Lin, J. T., Wang, J. T., Wang, T. H., Wu, M. S., & Chen, C. J. (1993). Helicobacter pylori infection in early and advanced gastric adenocarcinoma: a seroprevalence study in 143 Taiwanese patients. Hepato-gastroenterology, 40(6), pp. 596-9.
Lin JT, et al. Helicobacter Pylori Infection in Early and Advanced Gastric Adenocarcinoma: a Seroprevalence Study in 143 Taiwanese Patients. Hepatogastroenterology. 1993;40(6):596-9. PubMed PMID: 8119647.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Helicobacter pylori infection in early and advanced gastric adenocarcinoma: a seroprevalence study in 143 Taiwanese patients. AU - Lin,J T, AU - Wang,J T, AU - Wang,T H, AU - Wu,M S, AU - Chen,C J, PY - 1993/12/1/pubmed PY - 1993/12/1/medline PY - 1993/12/1/entrez SP - 596 EP - 9 JF - Hepato-gastroenterology JO - Hepatogastroenterology VL - 40 IS - 6 N2 - The association between gastric adenocarcinoma and Helicobacter pylori infection remains controversial. A seroprevalence study of Helicobacter pylori infection in 143 patients with gastric adenocarcinoma and a control group of 823 subjects randomly selected from four areas in Taiwan, was carried out to elucidate the association. The overall seropositivity of Helicobacter pylori in gastric adenocarcinoma patients (62.9%) was higher than in controls (54.4%), but the difference was not statistically significant (p > 0.05). The seropositivity of early gastric adenocarcinoma (61.5%) was not significantly different from that of advanced gastric adenocarcinoma (63.2%). Various demographic factors such as sex, blood type, cigarette smoking, tumor histology and location were not associated with the seroprevalence of Helicobacter pylori. The age-specific seroprevalence of Helicobacter pylori tended to be higher in younger patients and decreased after the age of 60 years in gastric adenocarcinoma, in contrast to a stepwise increase of seropositivity in controls. This suggests that Helicobacter pylori infection in early life may be a contributory factor in gastric carcinogenesis. SN - 0172-6390 UR - https://www.unboundmedicine.com/medline/citation/8119647/Helicobacter_pylori_infection_in_early_and_advanced_gastric_adenocarcinoma:_a_seroprevalence_study_in_143_Taiwanese_patients_ L2 - https://medlineplus.gov/helicobacterpyloriinfections.html DB - PRIME DP - Unbound Medicine ER -