Tags

Type your tag names separated by a space and hit enter

Dietary iron intake and risk of coronary disease among men.

Abstract

BACKGROUND

We prospectively studied iron intake in relation to the incidence of coronary disease in a 4-year follow-up of 44,933 men (with no previous history of cardiovascular disease) aged 40 to 75 years in 1986 who completed a food frequency questionnaire at baseline.

METHODS AND RESULTS

We documented 844 incident cases of coronary disease (249 nonfatal myocardial infarctions, 137 coronary disease fatalities, and 458 bypass operations or angioplasties). After adjustment for established risk factors, there was no significant association between total iron intake and risk of coronary heart disease. Men in the highest quintile of total intake (median, 37 mg/d) had a relative risk (RR) of fatal coronary disease or nonfatal myocardial infarction of 0.73 (95% confidence intervals [CI], 0.51, 1.06) compared with men in the lowest quintile of intake (median, 11 mg/d). Dietary intake of heme iron--mainly from red meat--also was not significantly associated with risk of coronary heart disease. However, incidence of fatal coronary disease or nonfatal myocardial infarction was higher among men in the top quintile of heme iron intake compared with men in the lowest quintile (RR, 1.42; 95% CI, 1.02, 1.98). This association remained after adjustment for dietary cholesterol and fats. Heme iron but not total iron intake was positively correlated with serum ferritin among 123 members of the cohort who participated in a validation study.

CONCLUSIONS

These results do not support the hypothesis that dietary iron in general increases coronary risk in men; they are consistent, however, with an increased risk of myocardial infarction among men with higher intake of heme iron, which is itself positively associated with iron stores.

Links

  • Aggregator Full Text
  • Authors+Show Affiliations

    ,

    Department of Epidemiology, Harvard School of Public Health, Boston, MA.

    , , ,

    Source

    Circulation 89:3 1994 Mar pg 969-74

    MeSH

    Adult
    Aged
    Cohort Studies
    Coronary Disease
    Diet
    Follow-Up Studies
    Health Personnel
    Heme
    Humans
    Incidence
    Iron
    Male
    Meat
    Middle Aged
    Multivariate Analysis
    Prospective Studies
    Risk Factors
    Time Factors

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    8124837

    Citation

    Ascherio, A, et al. "Dietary Iron Intake and Risk of Coronary Disease Among Men." Circulation, vol. 89, no. 3, 1994, pp. 969-74.
    Ascherio A, Willett WC, Rimm EB, et al. Dietary iron intake and risk of coronary disease among men. Circulation. 1994;89(3):969-74.
    Ascherio, A., Willett, W. C., Rimm, E. B., Giovannucci, E. L., & Stampfer, M. J. (1994). Dietary iron intake and risk of coronary disease among men. Circulation, 89(3), pp. 969-74.
    Ascherio A, et al. Dietary Iron Intake and Risk of Coronary Disease Among Men. Circulation. 1994;89(3):969-74. PubMed PMID: 8124837.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary iron intake and risk of coronary disease among men. AU - Ascherio,A, AU - Willett,W C, AU - Rimm,E B, AU - Giovannucci,E L, AU - Stampfer,M J, PY - 1994/3/1/pubmed PY - 1994/3/1/medline PY - 1994/3/1/entrez SP - 969 EP - 74 JF - Circulation JO - Circulation VL - 89 IS - 3 N2 - BACKGROUND: We prospectively studied iron intake in relation to the incidence of coronary disease in a 4-year follow-up of 44,933 men (with no previous history of cardiovascular disease) aged 40 to 75 years in 1986 who completed a food frequency questionnaire at baseline. METHODS AND RESULTS: We documented 844 incident cases of coronary disease (249 nonfatal myocardial infarctions, 137 coronary disease fatalities, and 458 bypass operations or angioplasties). After adjustment for established risk factors, there was no significant association between total iron intake and risk of coronary heart disease. Men in the highest quintile of total intake (median, 37 mg/d) had a relative risk (RR) of fatal coronary disease or nonfatal myocardial infarction of 0.73 (95% confidence intervals [CI], 0.51, 1.06) compared with men in the lowest quintile of intake (median, 11 mg/d). Dietary intake of heme iron--mainly from red meat--also was not significantly associated with risk of coronary heart disease. However, incidence of fatal coronary disease or nonfatal myocardial infarction was higher among men in the top quintile of heme iron intake compared with men in the lowest quintile (RR, 1.42; 95% CI, 1.02, 1.98). This association remained after adjustment for dietary cholesterol and fats. Heme iron but not total iron intake was positively correlated with serum ferritin among 123 members of the cohort who participated in a validation study. CONCLUSIONS: These results do not support the hypothesis that dietary iron in general increases coronary risk in men; they are consistent, however, with an increased risk of myocardial infarction among men with higher intake of heme iron, which is itself positively associated with iron stores. SN - 0009-7322 UR - https://www.unboundmedicine.com/medline/citation/8124837/Dietary_iron_intake_and_risk_of_coronary_disease_among_men_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=8124837.ui DB - PRIME DP - Unbound Medicine ER -