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Anti-SSA/Ro and anti-SSB/La antibodies in serum and saliva of patients with Sjogren's syndrome.
Clin Rheumatol. 1993 Dec; 12(4):471-4.CR

Abstract

Autoantibodies to SSA/Ro and SSB/La antigens may have a pathogenic role in photosensitive skin disease and congenital complete heart block. Since salivary glands are the major target organ in Sjogren's syndrome (SS) we wondered whether these autoantibodies are present in saliva and may be involved in the sicca syndrome. Whole saliva and serum were collected from 15 patients with SS. Elisa analysis disclosed that 8 of the patients had anti-SSA/Ro antibodies, while 6 of them also had anti-SSB/La antibodies. Studies of immunoglobulin classes showed that the sera contained mainly IgG and IgM anti-SSA/Ro or SSB/La antibodies. One serum also contained IgA antibodies. Analysis of the saliva showed that in all positive samples IgG and IgA classes were present, while none of them contained IgM. Elisa and immunoblot analysis of sera and saliva from SLE patients without the sicca syndrome disclosed that both fluids contained anti-Sm antibodies. These findings suggest that the presence of anti-SSA/Ro and anti-SSB/La antibodies in saliva is not a unique phenomenon, characterizing the sicca syndrome. Therefore, their role in the pathogenicity of the Sjogren's syndrome has to be elucidated.

Authors+Show Affiliations

Dept. of Medicine, Hadassah University Hospital, Jerusalem, Israel.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8124907

Citation

Ben-Chetrit, E, et al. "Anti-SSA/Ro and anti-SSB/La Antibodies in Serum and Saliva of Patients With Sjogren's Syndrome." Clinical Rheumatology, vol. 12, no. 4, 1993, pp. 471-4.
Ben-Chetrit E, Fischel R, Rubinow A. Anti-SSA/Ro and anti-SSB/La antibodies in serum and saliva of patients with Sjogren's syndrome. Clin Rheumatol. 1993;12(4):471-4.
Ben-Chetrit, E., Fischel, R., & Rubinow, A. (1993). Anti-SSA/Ro and anti-SSB/La antibodies in serum and saliva of patients with Sjogren's syndrome. Clinical Rheumatology, 12(4), 471-4.
Ben-Chetrit E, Fischel R, Rubinow A. Anti-SSA/Ro and anti-SSB/La Antibodies in Serum and Saliva of Patients With Sjogren's Syndrome. Clin Rheumatol. 1993;12(4):471-4. PubMed PMID: 8124907.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-SSA/Ro and anti-SSB/La antibodies in serum and saliva of patients with Sjogren's syndrome. AU - Ben-Chetrit,E, AU - Fischel,R, AU - Rubinow,A, PY - 1993/12/1/pubmed PY - 1993/12/1/medline PY - 1993/12/1/entrez SP - 471 EP - 4 JF - Clinical rheumatology JO - Clin Rheumatol VL - 12 IS - 4 N2 - Autoantibodies to SSA/Ro and SSB/La antigens may have a pathogenic role in photosensitive skin disease and congenital complete heart block. Since salivary glands are the major target organ in Sjogren's syndrome (SS) we wondered whether these autoantibodies are present in saliva and may be involved in the sicca syndrome. Whole saliva and serum were collected from 15 patients with SS. Elisa analysis disclosed that 8 of the patients had anti-SSA/Ro antibodies, while 6 of them also had anti-SSB/La antibodies. Studies of immunoglobulin classes showed that the sera contained mainly IgG and IgM anti-SSA/Ro or SSB/La antibodies. One serum also contained IgA antibodies. Analysis of the saliva showed that in all positive samples IgG and IgA classes were present, while none of them contained IgM. Elisa and immunoblot analysis of sera and saliva from SLE patients without the sicca syndrome disclosed that both fluids contained anti-Sm antibodies. These findings suggest that the presence of anti-SSA/Ro and anti-SSB/La antibodies in saliva is not a unique phenomenon, characterizing the sicca syndrome. Therefore, their role in the pathogenicity of the Sjogren's syndrome has to be elucidated. SN - 0770-3198 UR - https://www.unboundmedicine.com/medline/citation/8124907/Anti_SSA/Ro_and_anti_SSB/La_antibodies_in_serum_and_saliva_of_patients_with_Sjogren's_syndrome_ L2 - https://medlineplus.gov/sjogrenssyndrome.html DB - PRIME DP - Unbound Medicine ER -