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Urinary 6-hydroxymelatonin sulfate as a measure of melatonin secretion during acute tryptophan depletion.
Psychoneuroendocrinology 1993; 18(8):567-78P

Abstract

The essential amino acid tryptophan (TRP) is the precursor for serotonin (5-HT), which is in turn an intermediary product in the synthesis of melatonin. Acute TRP depletion has recently been shown to decrease nocturnal plasma levels of melatonin in humans. Melatonin is metabolized to 6-hydroxymelatonin sulfate (6-SM), a highly stable end-product which is excreted into urine. To determine the effects of TRP bioavailability on 6-SM, 11 healthy volunteers underwent active and sham TRP depletion in a randomized, double-blind fashion. Samples of plasma free and total TRP, plasma melatonin, and urinary 6-SM were obtained before and after the depletion. Acute TRP depletion decreased free and total plasma tryptophan levels by more than 80% from baseline levels. Nocturnal 6-SM excretion was significantly decreased and highly correlated with decreases in plasma melatonin. These results suggest that nocturnal urinary 6-SM excretion is a valid measure of melatonin secretion under conditions of decreased 5-HT function. Collection of urine for 6-SM is considerably easier than nocturnal plasma sampling for melatonin. Further studies are needed to clarify the relationship between 6-SM excretion and other measures of 5-HT function in neuropsychiatric disorders.

Authors+Show Affiliations

Clinical Neuroscience Research Unit, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, New Haven 06519.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8127947

Citation

Zimmermann, R C., et al. "Urinary 6-hydroxymelatonin Sulfate as a Measure of Melatonin Secretion During Acute Tryptophan Depletion." Psychoneuroendocrinology, vol. 18, no. 8, 1993, pp. 567-78.
Zimmermann RC, McDougle CJ, Schumacher M, et al. Urinary 6-hydroxymelatonin sulfate as a measure of melatonin secretion during acute tryptophan depletion. Psychoneuroendocrinology. 1993;18(8):567-78.
Zimmermann, R. C., McDougle, C. J., Schumacher, M., Olcese, J., Heninger, G. R., & Price, L. H. (1993). Urinary 6-hydroxymelatonin sulfate as a measure of melatonin secretion during acute tryptophan depletion. Psychoneuroendocrinology, 18(8), pp. 567-78.
Zimmermann RC, et al. Urinary 6-hydroxymelatonin Sulfate as a Measure of Melatonin Secretion During Acute Tryptophan Depletion. Psychoneuroendocrinology. 1993;18(8):567-78. PubMed PMID: 8127947.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Urinary 6-hydroxymelatonin sulfate as a measure of melatonin secretion during acute tryptophan depletion. AU - Zimmermann,R C, AU - McDougle,C J, AU - Schumacher,M, AU - Olcese,J, AU - Heninger,G R, AU - Price,L H, PY - 1993/1/1/pubmed PY - 1993/1/1/medline PY - 1993/1/1/entrez SP - 567 EP - 78 JF - Psychoneuroendocrinology JO - Psychoneuroendocrinology VL - 18 IS - 8 N2 - The essential amino acid tryptophan (TRP) is the precursor for serotonin (5-HT), which is in turn an intermediary product in the synthesis of melatonin. Acute TRP depletion has recently been shown to decrease nocturnal plasma levels of melatonin in humans. Melatonin is metabolized to 6-hydroxymelatonin sulfate (6-SM), a highly stable end-product which is excreted into urine. To determine the effects of TRP bioavailability on 6-SM, 11 healthy volunteers underwent active and sham TRP depletion in a randomized, double-blind fashion. Samples of plasma free and total TRP, plasma melatonin, and urinary 6-SM were obtained before and after the depletion. Acute TRP depletion decreased free and total plasma tryptophan levels by more than 80% from baseline levels. Nocturnal 6-SM excretion was significantly decreased and highly correlated with decreases in plasma melatonin. These results suggest that nocturnal urinary 6-SM excretion is a valid measure of melatonin secretion under conditions of decreased 5-HT function. Collection of urine for 6-SM is considerably easier than nocturnal plasma sampling for melatonin. Further studies are needed to clarify the relationship between 6-SM excretion and other measures of 5-HT function in neuropsychiatric disorders. SN - 0306-4530 UR - https://www.unboundmedicine.com/medline/citation/8127947/Urinary_6_hydroxymelatonin_sulfate_as_a_measure_of_melatonin_secretion_during_acute_tryptophan_depletion_ L2 - https://ClinicalTrials.gov/search/term=8127947 [PUBMED-IDS] DB - PRIME DP - Unbound Medicine ER -