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Effect of glyceryl trinitrate on antral motility and symptoms in patients with functional dyspepsia.
Scand J Gastroenterol. 1994 Jan; 29(1):23-8.SJ

Abstract

Nitric oxide (NO) is considered to be an important physiologic non-adrenergic, non-cholinergic vagal transmitter in the neural regulation of gastric adaptive relaxation, which accommodates the gastric fundus to ingested food. Ten consecutive patients with functional dyspepsia (FD) and erosive prepyloric changes were studied twice on separate days, once without drug administration and once after intake of one tablet of glyceryl trinitrate (GTN), 2.6 mg, 2 h before ingestion of 500 ml meat soup. Width of antral area, amplitude (maximal area reduction as fraction of relaxed area), and frequency of antral contractions were measured ultrasonographically in standardized sections. Postprandial abdominal discomfort was scored. Without GTN, postprandial antral area and symptom scores were positively correlated (r = 0.64, p = 0.05). After administration of GTN, antral area both fasting and 10 min postprandially was reduced (p = 0.02 and p = 0.01, respectively), whereas amplitude and motility index of antral contractions tended to increase (p = 0.07 and p = 0.09, respectively). Abdominal discomfort was not significantly reduced by GTN (p = 0.13). The results suggest a relationship between postprandial antral distension and discomfort. Moreover, GTN (by generation of NO) reduced abnormal antral filling in patients with FD.

Authors+Show Affiliations

Medical Dept. A, University of Bergen, Norway.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8128173

Citation

Hausken, T, and A Berstad. "Effect of Glyceryl Trinitrate On Antral Motility and Symptoms in Patients With Functional Dyspepsia." Scandinavian Journal of Gastroenterology, vol. 29, no. 1, 1994, pp. 23-8.
Hausken T, Berstad A. Effect of glyceryl trinitrate on antral motility and symptoms in patients with functional dyspepsia. Scand J Gastroenterol. 1994;29(1):23-8.
Hausken, T., & Berstad, A. (1994). Effect of glyceryl trinitrate on antral motility and symptoms in patients with functional dyspepsia. Scandinavian Journal of Gastroenterology, 29(1), 23-8.
Hausken T, Berstad A. Effect of Glyceryl Trinitrate On Antral Motility and Symptoms in Patients With Functional Dyspepsia. Scand J Gastroenterol. 1994;29(1):23-8. PubMed PMID: 8128173.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of glyceryl trinitrate on antral motility and symptoms in patients with functional dyspepsia. AU - Hausken,T, AU - Berstad,A, PY - 1994/1/1/pubmed PY - 1994/1/1/medline PY - 1994/1/1/entrez SP - 23 EP - 8 JF - Scandinavian journal of gastroenterology JO - Scand J Gastroenterol VL - 29 IS - 1 N2 - Nitric oxide (NO) is considered to be an important physiologic non-adrenergic, non-cholinergic vagal transmitter in the neural regulation of gastric adaptive relaxation, which accommodates the gastric fundus to ingested food. Ten consecutive patients with functional dyspepsia (FD) and erosive prepyloric changes were studied twice on separate days, once without drug administration and once after intake of one tablet of glyceryl trinitrate (GTN), 2.6 mg, 2 h before ingestion of 500 ml meat soup. Width of antral area, amplitude (maximal area reduction as fraction of relaxed area), and frequency of antral contractions were measured ultrasonographically in standardized sections. Postprandial abdominal discomfort was scored. Without GTN, postprandial antral area and symptom scores were positively correlated (r = 0.64, p = 0.05). After administration of GTN, antral area both fasting and 10 min postprandially was reduced (p = 0.02 and p = 0.01, respectively), whereas amplitude and motility index of antral contractions tended to increase (p = 0.07 and p = 0.09, respectively). Abdominal discomfort was not significantly reduced by GTN (p = 0.13). The results suggest a relationship between postprandial antral distension and discomfort. Moreover, GTN (by generation of NO) reduced abnormal antral filling in patients with FD. SN - 0036-5521 UR - https://www.unboundmedicine.com/medline/citation/8128173/Effect_of_glyceryl_trinitrate_on_antral_motility_and_symptoms_in_patients_with_functional_dyspepsia_ L2 - https://www.tandfonline.com/doi/full/10.3109/00365529409090432 DB - PRIME DP - Unbound Medicine ER -