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Endolymphatic sac blood flow versus cochlear blood flow following intravenous administration of isosorbide in guinea pigs.
Acta Otolaryngol Suppl. 1994; 510:29-32.AO

Abstract

Endolymphatic sac (ES) blood flow (ESBF) and cochlear blood flow (CBF) were measured in different groups of guinea pigs by laser-Doppler flowmetry (Advance Laser Flowmeter, Model ALF 2100) after the intravenous administration of 70% isosorbide (1.6 ml/kg). The measurements were made under general anesthesia with intraperitoneal pentobarbital sodium. Respiration was controlled by a respirator after tracheotomy, and blood pressure was monitored through the femoral artery (Gould Statham P23 ID Pressure Transducer). For ESBF measurements, a probe was placed on the right ES after entering the posterior cranial fossa via the dorsal approach. For CBF measurements, a probe was placed on the basal turn of the right cochlea via the ventral approach. Isosorbide was administered intravenously through the jugular vein for 60 s. Both ESBF and CBF increased immediately after administration, reached a peak within 3-6 min and decreased gradually to their initial baseline levels in 11-15 min. Both blood flow changes almost always corresponded to systemic blood pressure changes, although a slight delay was observed in blood pressure compared to the blood flow. The magnitude of the CBF response tended to be greater than that of the ESBF response (p < 0.1). This may result from the anatomical differences in the two blood supplies, i.e., from the vertebral artery (CBF) and the external carotid artery (ESBF).

Authors+Show Affiliations

Department of Otolaryngology, Shiga University of Medical Science, Otsu, Japan.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8128869

Citation

Yazawa, Y, and M Kitahara. "Endolymphatic Sac Blood Flow Versus Cochlear Blood Flow Following Intravenous Administration of Isosorbide in Guinea Pigs." Acta Oto-laryngologica. Supplementum, vol. 510, 1994, pp. 29-32.
Yazawa Y, Kitahara M. Endolymphatic sac blood flow versus cochlear blood flow following intravenous administration of isosorbide in guinea pigs. Acta Otolaryngol Suppl. 1994;510:29-32.
Yazawa, Y., & Kitahara, M. (1994). Endolymphatic sac blood flow versus cochlear blood flow following intravenous administration of isosorbide in guinea pigs. Acta Oto-laryngologica. Supplementum, 510, 29-32.
Yazawa Y, Kitahara M. Endolymphatic Sac Blood Flow Versus Cochlear Blood Flow Following Intravenous Administration of Isosorbide in Guinea Pigs. Acta Otolaryngol Suppl. 1994;510:29-32. PubMed PMID: 8128869.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endolymphatic sac blood flow versus cochlear blood flow following intravenous administration of isosorbide in guinea pigs. AU - Yazawa,Y, AU - Kitahara,M, PY - 1994/1/1/pubmed PY - 1994/1/1/medline PY - 1994/1/1/entrez SP - 29 EP - 32 JF - Acta oto-laryngologica. Supplementum JO - Acta Otolaryngol Suppl VL - 510 N2 - Endolymphatic sac (ES) blood flow (ESBF) and cochlear blood flow (CBF) were measured in different groups of guinea pigs by laser-Doppler flowmetry (Advance Laser Flowmeter, Model ALF 2100) after the intravenous administration of 70% isosorbide (1.6 ml/kg). The measurements were made under general anesthesia with intraperitoneal pentobarbital sodium. Respiration was controlled by a respirator after tracheotomy, and blood pressure was monitored through the femoral artery (Gould Statham P23 ID Pressure Transducer). For ESBF measurements, a probe was placed on the right ES after entering the posterior cranial fossa via the dorsal approach. For CBF measurements, a probe was placed on the basal turn of the right cochlea via the ventral approach. Isosorbide was administered intravenously through the jugular vein for 60 s. Both ESBF and CBF increased immediately after administration, reached a peak within 3-6 min and decreased gradually to their initial baseline levels in 11-15 min. Both blood flow changes almost always corresponded to systemic blood pressure changes, although a slight delay was observed in blood pressure compared to the blood flow. The magnitude of the CBF response tended to be greater than that of the ESBF response (p < 0.1). This may result from the anatomical differences in the two blood supplies, i.e., from the vertebral artery (CBF) and the external carotid artery (ESBF). SN - 0365-5237 UR - https://www.unboundmedicine.com/medline/citation/8128869/Endolymphatic_sac_blood_flow_versus_cochlear_blood_flow_following_intravenous_administration_of_isosorbide_in_guinea_pigs_ DB - PRIME DP - Unbound Medicine ER -