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Autoimmune thyroid disorders and coeliac disease.

Abstract

Eighty-three patients with autoimmune thyroid disorders were screened for coeliac disease. The screening was performed with IgA-class reticulin and endomysium antibody, IgA- and IgG-class gliadin antibody tests, and various biochemical tests for malabsorption. None of the tested subjects had selective IgA deficiency, which excludes the possibility of not detecting positives by an IgA-class test. Of the 83 patients, three asymptomatic coeliac patients were found, and one patient with coeliac disease previously diagnosed, an overall frequency of 4.8%. In addition, 25 patients with a solitary nodule of the thyroid gland were examined and one of them (4%) was found to have coeliac disease. By contrast, one (0.4%) out of 249 age- and sex-matched blood donors was found to have coeliac disease. All newly detected coeliac patients had IgA-class gliadin, reticulin and endomysium antibodies, but none of the patients had any gastrointestinal symptoms or abnormal biochemical findings suggesting coeliac disease. Treatment of thyroid disorders and coeliac disease was successful in these patients. The present results confirm that the frequency of subclinical coeliac disease is increased among patients with autoimmune thyroid disorders. IgA-class reticulin, endomysium or gliadin antibody tests are suitable screening methods for detecting these patients, as far as selective IgA-deficiency is excluded.

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Authors+Show Affiliations

,

Department of Clinical Sciences, University of Tampere, Finland.

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Source

European journal of endocrinology 130:2 1994 Feb pg 137-40

MeSH

Adult
Atrophy
Autoantibodies
Autoimmune Diseases
Celiac Disease
Female
Gliadin
Graves Disease
Humans
Immunoglobulin A
Immunoglobulin G
Intestine, Small
Male
Microvilli
Middle Aged
Myofibrils
Reticulin
Thyroid Nodule
Thyroiditis, Autoimmune

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8130887

Citation

Collin, P, et al. "Autoimmune Thyroid Disorders and Coeliac Disease." European Journal of Endocrinology, vol. 130, no. 2, 1994, pp. 137-40.
Collin P, Salmi J, Hällström O, et al. Autoimmune thyroid disorders and coeliac disease. Eur J Endocrinol. 1994;130(2):137-40.
Collin, P., Salmi, J., Hällström, O., Reunala, T., & Pasternack, A. (1994). Autoimmune thyroid disorders and coeliac disease. European Journal of Endocrinology, 130(2), pp. 137-40.
Collin P, et al. Autoimmune Thyroid Disorders and Coeliac Disease. Eur J Endocrinol. 1994;130(2):137-40. PubMed PMID: 8130887.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Autoimmune thyroid disorders and coeliac disease. AU - Collin,P, AU - Salmi,J, AU - Hällström,O, AU - Reunala,T, AU - Pasternack,A, PY - 1994/2/1/pubmed PY - 1994/2/1/medline PY - 1994/2/1/entrez SP - 137 EP - 40 JF - European journal of endocrinology JO - Eur. J. Endocrinol. VL - 130 IS - 2 N2 - Eighty-three patients with autoimmune thyroid disorders were screened for coeliac disease. The screening was performed with IgA-class reticulin and endomysium antibody, IgA- and IgG-class gliadin antibody tests, and various biochemical tests for malabsorption. None of the tested subjects had selective IgA deficiency, which excludes the possibility of not detecting positives by an IgA-class test. Of the 83 patients, three asymptomatic coeliac patients were found, and one patient with coeliac disease previously diagnosed, an overall frequency of 4.8%. In addition, 25 patients with a solitary nodule of the thyroid gland were examined and one of them (4%) was found to have coeliac disease. By contrast, one (0.4%) out of 249 age- and sex-matched blood donors was found to have coeliac disease. All newly detected coeliac patients had IgA-class gliadin, reticulin and endomysium antibodies, but none of the patients had any gastrointestinal symptoms or abnormal biochemical findings suggesting coeliac disease. Treatment of thyroid disorders and coeliac disease was successful in these patients. The present results confirm that the frequency of subclinical coeliac disease is increased among patients with autoimmune thyroid disorders. IgA-class reticulin, endomysium or gliadin antibody tests are suitable screening methods for detecting these patients, as far as selective IgA-deficiency is excluded. SN - 0804-4643 UR - https://www.unboundmedicine.com/medline/citation/8130887/Autoimmune_thyroid_disorders_and_coeliac_disease_ L2 - https://medlineplus.gov/autoimmunediseases.html DB - PRIME DP - Unbound Medicine ER -