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Clinical usefulness of mean corpuscular volume and red cell distribution width in iron deficient blood donors.
Rev Invest Clin. 1993 Sep-Oct; 45(5):469-72.RI

Abstract

The clinical efficacy of the red cell distribution width (RDW > 14.2%) and the mean corpuscular volume (MCV < 83.5 fL) in detecting iron deficiency was evaluated in female blood donors. Employing transferrin saturation < 17%, the prevalence of iron deficiency in 296 female donors was 23%, and in 635 male donors 1.1%. In the total female population, the sensitivity and specificity of the indices were 78% and 92%, respectively, but they were higher in anemic females (sensitivity 90% and positive predictive value 92%) than in non anemic females (sensitivity 58% and positive predictive value 50%). Our results confirm that there is an overlap in the levels of RDW and MCV between the iron and non iron deficient subjects, and these overlap seems to be more remarkable in the non anemic individuals. We conclude that these erythrocyte indices could be useful to identify iron deficiency in anemic female blood donors, but not in non anemic ones.

Authors+Show Affiliations

Piedras J
Centro Nacional de la Transfusión Sanguínea, México, D.F.
Alvarez E
No affiliation info available
Herrera FM
No affiliation info available
Córdova MS
No affiliation info available

MeSH

AdolescentAdultAgedAnemia, HypochromicBlood DonorsErythrocyte IndicesFemaleFlow CytometryHumansMaleMiddle AgedPredictive Value of TestsPrevalenceSensitivity and SpecificitySex FactorsTransferrin

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

8134729

Citation

Piedras, J, et al. "Clinical Usefulness of Mean Corpuscular Volume and Red Cell Distribution Width in Iron Deficient Blood Donors." Revista De Investigacion Clinica; Organo Del Hospital De Enfermedades De La Nutricion, vol. 45, no. 5, 1993, pp. 469-72.
Piedras J, Alvarez E, Herrera FM, et al. Clinical usefulness of mean corpuscular volume and red cell distribution width in iron deficient blood donors. Rev Invest Clin. 1993;45(5):469-72.
Piedras, J., Alvarez, E., Herrera, F. M., & Córdova, M. S. (1993). Clinical usefulness of mean corpuscular volume and red cell distribution width in iron deficient blood donors. Revista De Investigacion Clinica; Organo Del Hospital De Enfermedades De La Nutricion, 45(5), 469-72.
Piedras J, et al. Clinical Usefulness of Mean Corpuscular Volume and Red Cell Distribution Width in Iron Deficient Blood Donors. Rev Invest Clin. 1993 Sep-Oct;45(5):469-72. PubMed PMID: 8134729.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical usefulness of mean corpuscular volume and red cell distribution width in iron deficient blood donors. AU - Piedras,J, AU - Alvarez,E, AU - Herrera,F M, AU - Córdova,M S, PY - 1993/9/1/pubmed PY - 1993/9/1/medline PY - 1993/9/1/entrez SP - 469 EP - 72 JF - Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion JO - Rev Invest Clin VL - 45 IS - 5 N2 - The clinical efficacy of the red cell distribution width (RDW > 14.2%) and the mean corpuscular volume (MCV < 83.5 fL) in detecting iron deficiency was evaluated in female blood donors. Employing transferrin saturation < 17%, the prevalence of iron deficiency in 296 female donors was 23%, and in 635 male donors 1.1%. In the total female population, the sensitivity and specificity of the indices were 78% and 92%, respectively, but they were higher in anemic females (sensitivity 90% and positive predictive value 92%) than in non anemic females (sensitivity 58% and positive predictive value 50%). Our results confirm that there is an overlap in the levels of RDW and MCV between the iron and non iron deficient subjects, and these overlap seems to be more remarkable in the non anemic individuals. We conclude that these erythrocyte indices could be useful to identify iron deficiency in anemic female blood donors, but not in non anemic ones. SN - 0034-8376 UR - https://www.unboundmedicine.com/medline/citation/8134729/Clinical_usefulness_of_mean_corpuscular_volume_and_red_cell_distribution_width_in_iron_deficient_blood_donors_ L2 - https://medlineplus.gov/bloodtransfusionanddonation.html DB - PRIME DP - Unbound Medicine ER -