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Screening results in a family cancer clinic: five years experience.
Anticancer Res. 1993 Nov-Dec; 13(6B):2581-5.AR

Abstract

We present our experience so far of screening individuals referred to the Cancer family clinic at St. Mark's Hospital from 1986, with the results of the follow-up of these individuals. 651 individuals from 436 families were offered colonoscopic surveillance at five-yearly intervals. The median age at which the examination was performed was 41 years. Families were subdivided according to family history; 15.8% conformed to the Amsterdam criteria for hereditary nonpolyposis colorectal cancer (HNPCC). The pathological findings were correlated with the type of pedigree; abnormalities were more often found in males than females (30% of colonoscopies in males revealed adenomas, and 17% in females), and adenoma prevalence increased with age. Adenoma prevalence (27% v.s. 21% at all ages, and 38% v.s. 25% in individuals over the age of 35y.), multiple adenomas and the proportion of proximally sited adenomas were all higher in HNPCC families; however, dysplasia and villous or large adenomas were not more common in individuals from HNPCC families. Four of the 7 carcinoma detected were in HNPCC families (3% v.s. 0.6%).

Authors+Show Affiliations

St. Mark's Hospital, London, U.K.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8135498

Citation

Hodgson, S V., et al. "Screening Results in a Family Cancer Clinic: Five Years Experience." Anticancer Research, vol. 13, no. 6B, 1993, pp. 2581-5.
Hodgson SV, Harocopos C, Gaglia P. Screening results in a family cancer clinic: five years experience. Anticancer Res. 1993;13(6B):2581-5.
Hodgson, S. V., Harocopos, C., & Gaglia, P. (1993). Screening results in a family cancer clinic: five years experience. Anticancer Research, 13(6B), 2581-5.
Hodgson SV, Harocopos C, Gaglia P. Screening Results in a Family Cancer Clinic: Five Years Experience. Anticancer Res. 1993 Nov-Dec;13(6B):2581-5. PubMed PMID: 8135498.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Screening results in a family cancer clinic: five years experience. AU - Hodgson,S V, AU - Harocopos,C, AU - Gaglia,P, PY - 1993/11/1/pubmed PY - 1993/11/1/medline PY - 1993/11/1/entrez SP - 2581 EP - 5 JF - Anticancer research JO - Anticancer Res. VL - 13 IS - 6B N2 - We present our experience so far of screening individuals referred to the Cancer family clinic at St. Mark's Hospital from 1986, with the results of the follow-up of these individuals. 651 individuals from 436 families were offered colonoscopic surveillance at five-yearly intervals. The median age at which the examination was performed was 41 years. Families were subdivided according to family history; 15.8% conformed to the Amsterdam criteria for hereditary nonpolyposis colorectal cancer (HNPCC). The pathological findings were correlated with the type of pedigree; abnormalities were more often found in males than females (30% of colonoscopies in males revealed adenomas, and 17% in females), and adenoma prevalence increased with age. Adenoma prevalence (27% v.s. 21% at all ages, and 38% v.s. 25% in individuals over the age of 35y.), multiple adenomas and the proportion of proximally sited adenomas were all higher in HNPCC families; however, dysplasia and villous or large adenomas were not more common in individuals from HNPCC families. Four of the 7 carcinoma detected were in HNPCC families (3% v.s. 0.6%). SN - 0250-7005 UR - https://www.unboundmedicine.com/medline/citation/8135498/Screening_results_in_a_family_cancer_clinic:_five_years_experience_ L2 - https://medlineplus.gov/familyissues.html DB - PRIME DP - Unbound Medicine ER -