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New progestogens in oral contraception.
Contraception. 1994 Jan; 49(1):1-32.C

Abstract

The major developments in combined oral contraceptives (COCs) have been a reduction in the total dose of both the oestrogen and progestogen administered per cycle and the introduction of new progestogens which are claimed to be more 'selective' than the older ones. This review examines in detail the clinical efficacy of the new COCs, where possible in comparison with those containing levonorgestrel or norethisterone, and their pharmacological effect on carbohydrate and lipid metabolism, haematological factors, pituitary-ovarian function and serum protein and androgen concentrations. Based mainly on the pharmacological evidence, the newer COCs are an improvement over the older low-dose formulations and are clearly preferable to the high-dose ones. However, the older low-dose COCs, despite many years of use, have not resulted in a high incidence of adverse effects. The increasing use of the new COCs, as evidenced by their increasing market share throughout Europe, does indicate that they have been well accepted in clinical practice.

Authors+Show Affiliations

Royal Postgraduate Medical School, London, UK.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Review

Language

eng

PubMed ID

8137623

Citation

Fotherby, K, and A D. Caldwell. "New Progestogens in Oral Contraception." Contraception, vol. 49, no. 1, 1994, pp. 1-32.
Fotherby K, Caldwell AD. New progestogens in oral contraception. Contraception. 1994;49(1):1-32.
Fotherby, K., & Caldwell, A. D. (1994). New progestogens in oral contraception. Contraception, 49(1), 1-32.
Fotherby K, Caldwell AD. New Progestogens in Oral Contraception. Contraception. 1994;49(1):1-32. PubMed PMID: 8137623.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - New progestogens in oral contraception. AU - Fotherby,K, AU - Caldwell,A D, PY - 1994/1/1/pubmed PY - 1994/1/1/medline PY - 1994/1/1/entrez KW - Biology KW - Carbohydrate Metabolic Effects KW - Contraception KW - Contraceptive Agents, Female--pharmacodynamics KW - Contraceptive Agents, Progestin--pharmacodynamics KW - Contraceptive Agents--pharmacodynamics KW - Contraceptive Methods KW - Contraceptive Usage KW - Desogestrel--pharmacodynamics KW - Family Planning KW - Gestodene--pharmacodynamics KW - Hematological Effects KW - Hemic System KW - Lipid Metabolic Effects KW - Lipids KW - Literature Review KW - Metabolic Effects KW - Method Acceptability KW - Norgestimate--pharmacodynamics KW - Oral Contraceptives KW - Oral Contraceptives, Low-dose KW - Physiology KW - Serum Protein Effects SP - 1 EP - 32 JF - Contraception JO - Contraception VL - 49 IS - 1 N2 - The major developments in combined oral contraceptives (COCs) have been a reduction in the total dose of both the oestrogen and progestogen administered per cycle and the introduction of new progestogens which are claimed to be more 'selective' than the older ones. This review examines in detail the clinical efficacy of the new COCs, where possible in comparison with those containing levonorgestrel or norethisterone, and their pharmacological effect on carbohydrate and lipid metabolism, haematological factors, pituitary-ovarian function and serum protein and androgen concentrations. Based mainly on the pharmacological evidence, the newer COCs are an improvement over the older low-dose formulations and are clearly preferable to the high-dose ones. However, the older low-dose COCs, despite many years of use, have not resulted in a high incidence of adverse effects. The increasing use of the new COCs, as evidenced by their increasing market share throughout Europe, does indicate that they have been well accepted in clinical practice. SN - 0010-7824 UR - https://www.unboundmedicine.com/medline/citation/8137623/New_progestogens_in_oral_contraception_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0010-7824(94)90106-6 DB - PRIME DP - Unbound Medicine ER -
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