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Levodopa-induced dyskinesias in Parkinson's disease phenomenology and pathophysiology.
Mov Disord. 1994 Jan; 9(1):2-12.MD

Abstract

The aim of this study was to provide further insight into the phenomenology and pathophysiology of monophasic and biphasic dyskinesias induced by levodopa in Parkinson's disease. For this purpose, the type, localization, severity, and timing of dyskinesias were evaluated in 15 parkinsonian patients in relation to motor disability after administration of levodopa using a video-electromyographic recording device. Foot-dystonia, myoclonus, and akathisia were observed in most patients. The dyskinesias started in the foot, usually on the side most affected by the disease, and spread in an "ascending wave" to the contralateral side, the trunk, and upper extremities. In a few patients, onset was axial, spreading almost instantaneously to all limbs. The dyskinesias were dystonic and ballistic at the start, and became increasingly choreic as they attained the upper limbs. Their intensity was maximal in the lower limbs, then progressively decreased, while increasing in upper limbs and head. The results indicate that there is no strict dichotomy between biphasic and monophasic dyskinesias. In other words, there is a "continuum" between the first dyskinesias and those observed during the period of maximal clinical improvement. These dyskinesias can also appear in reverse order, as if there were an "oscillator" determining a sequence of alternating patterns.

Authors+Show Affiliations

INSERM U 289, Hôpital de la Salpêtrière, Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8139601

Citation

Marconi, R, et al. "Levodopa-induced Dyskinesias in Parkinson's Disease Phenomenology and Pathophysiology." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 9, no. 1, 1994, pp. 2-12.
Marconi R, Lefebvre-Caparros D, Bonnet AM, et al. Levodopa-induced dyskinesias in Parkinson's disease phenomenology and pathophysiology. Mov Disord. 1994;9(1):2-12.
Marconi, R., Lefebvre-Caparros, D., Bonnet, A. M., Vidailhet, M., Dubois, B., & Agid, Y. (1994). Levodopa-induced dyskinesias in Parkinson's disease phenomenology and pathophysiology. Movement Disorders : Official Journal of the Movement Disorder Society, 9(1), 2-12.
Marconi R, et al. Levodopa-induced Dyskinesias in Parkinson's Disease Phenomenology and Pathophysiology. Mov Disord. 1994;9(1):2-12. PubMed PMID: 8139601.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Levodopa-induced dyskinesias in Parkinson's disease phenomenology and pathophysiology. AU - Marconi,R, AU - Lefebvre-Caparros,D, AU - Bonnet,A M, AU - Vidailhet,M, AU - Dubois,B, AU - Agid,Y, PY - 1994/1/1/pubmed PY - 1994/1/1/medline PY - 1994/1/1/entrez SP - 2 EP - 12 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 9 IS - 1 N2 - The aim of this study was to provide further insight into the phenomenology and pathophysiology of monophasic and biphasic dyskinesias induced by levodopa in Parkinson's disease. For this purpose, the type, localization, severity, and timing of dyskinesias were evaluated in 15 parkinsonian patients in relation to motor disability after administration of levodopa using a video-electromyographic recording device. Foot-dystonia, myoclonus, and akathisia were observed in most patients. The dyskinesias started in the foot, usually on the side most affected by the disease, and spread in an "ascending wave" to the contralateral side, the trunk, and upper extremities. In a few patients, onset was axial, spreading almost instantaneously to all limbs. The dyskinesias were dystonic and ballistic at the start, and became increasingly choreic as they attained the upper limbs. Their intensity was maximal in the lower limbs, then progressively decreased, while increasing in upper limbs and head. The results indicate that there is no strict dichotomy between biphasic and monophasic dyskinesias. In other words, there is a "continuum" between the first dyskinesias and those observed during the period of maximal clinical improvement. These dyskinesias can also appear in reverse order, as if there were an "oscillator" determining a sequence of alternating patterns. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/8139601/Levodopa_induced_dyskinesias_in_Parkinson's_disease_phenomenology_and_pathophysiology_ L2 - https://doi.org/10.1002/mds.870090103 DB - PRIME DP - Unbound Medicine ER -