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Anti-tumorigenic chalcones.
Stem Cells. 1994 Jan; 12(1):44-52.SC

Abstract

On the basis of our recent findings that licochalcone A isolated from Xin-jiang licorice showed anti-inflammatory and anti-tumorigenic activities, we synthesized more than 40 chalcone derivatives to examine their anti-tumorigenic activities. In vitro inhibitory activity against phosphorylation of phospholipids promoted by tetradecanoylphorbol-13-acetate (TPA) in HeLa cells was adopted as a screening test for anti-tumor-promoting effect. In vivo experimental mouse skin tumors initiated by dimethylbenz[a]-anthracene (DMBA) and promoted by TPA were used to test the anti-tumor-promoting effect of chalcones. In the results, 3'- and 4'-methyl-3-hydroxychalcone showed the highest potency in inhibiting tumorigenesis. They also showed a remarkable inhibitory effect on the proliferation of HGC-27 cells derived from human gastric cancer. We discuss the structure-activity relationship, including stereo-chemical phototransformation, of some chalcone derivatives with reference to their ultraviolet (UV) and nuclear magnetic resonance (NMR) spectroscopic data.

Authors+Show Affiliations

Shibata Laboratory of Natural Medicinal Materials, Minophagen Pharmaceutical Company, Tokyo, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8142919

Citation

Shibata, S. "Anti-tumorigenic Chalcones." Stem Cells (Dayton, Ohio), vol. 12, no. 1, 1994, pp. 44-52.
Shibata S. Anti-tumorigenic chalcones. Stem Cells. 1994;12(1):44-52.
Shibata, S. (1994). Anti-tumorigenic chalcones. Stem Cells (Dayton, Ohio), 12(1), 44-52.
Shibata S. Anti-tumorigenic Chalcones. Stem Cells. 1994;12(1):44-52. PubMed PMID: 8142919.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-tumorigenic chalcones. A1 - Shibata,S, PY - 1994/1/1/pubmed PY - 1994/1/1/medline PY - 1994/1/1/entrez SP - 44 EP - 52 JF - Stem cells (Dayton, Ohio) JO - Stem Cells VL - 12 IS - 1 N2 - On the basis of our recent findings that licochalcone A isolated from Xin-jiang licorice showed anti-inflammatory and anti-tumorigenic activities, we synthesized more than 40 chalcone derivatives to examine their anti-tumorigenic activities. In vitro inhibitory activity against phosphorylation of phospholipids promoted by tetradecanoylphorbol-13-acetate (TPA) in HeLa cells was adopted as a screening test for anti-tumor-promoting effect. In vivo experimental mouse skin tumors initiated by dimethylbenz[a]-anthracene (DMBA) and promoted by TPA were used to test the anti-tumor-promoting effect of chalcones. In the results, 3'- and 4'-methyl-3-hydroxychalcone showed the highest potency in inhibiting tumorigenesis. They also showed a remarkable inhibitory effect on the proliferation of HGC-27 cells derived from human gastric cancer. We discuss the structure-activity relationship, including stereo-chemical phototransformation, of some chalcone derivatives with reference to their ultraviolet (UV) and nuclear magnetic resonance (NMR) spectroscopic data. SN - 1066-5099 UR - https://www.unboundmedicine.com/medline/citation/8142919/Anti_tumorigenic_chalcones_ L2 - https://doi.org/10.1002/stem.5530120109 DB - PRIME DP - Unbound Medicine ER -