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Comparison of the efficacy of spironolactone versus flutamide in the treatment of hirsutism.
Fertil Steril. 1994 Apr; 61(4):613-6.FS

Abstract

OBJECTIVE

To compare the efficacy of two antiandrogens, spironolactone and flutamide, in the treatment of hirsutism.

PATIENTS, PARTICIPANTS

Twenty women with idiopathic hirsutism were randomized to receive either flutamide or spironolactone.

DESIGN

Twenty hirsute women were recruited from patients presenting to the hirsutism clinic in Marmara University, Istanbul. Each patient underwent a complete medical and gynecological examination as well as endocrine profile, hematologic, hepatic, and renal function analyses. Hirsutism scores were determined according to the Ferriman-Gallwey scoring system. These tests were then repeated at 3, 6, and 9 months of therapy. Ten patients received 250 mg of flutamide two times per day, and 10 patients received 100 mg of spironolactone for 9 months.

RESULTS

Ferriman-Gallwey scores were decreased significantly in both groups at the end of 9 months. The percent of change in hirsutism scores in flutamide and spironolactone group were as follows: 26.4% and 20.9% at 3 months; 39.5% and 32.9% at 6 months; and 46.4% and 39.6% at 9 months, respectively. There was a trend toward a better response with flutamide that did not achieve significance. None of the hormonal parameters changed significantly during this period of time. Irregular bleeding was observed in five patients (50%) of the spironolactone group, whereas none of the patients in the flutamide group experienced menstrual irregularity. Conversely, dry skin and increased appetite were experienced by two patients (20%) in the flutamide group but not in the spironolactone group.

CONCLUSION

These data suggest that both spironolactone and flutamide were similarly effective in treatment of hirsutism, and the pure antiandrogen flutamide is a safe and effective alternative in treatment.

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Authors+Show Affiliations

Erenus M
Department of Gynecology and Obstetrics, Marmara University Faculty of Medicine, Istanbul, Turkey.
Gürbüz O
No affiliation info available
Durmuşoğlu F
No affiliation info available
Demirçay Z
No affiliation info available
Pekin S
No affiliation info available

MeSH

AdolescentAdultDehydroepiandrosteroneDehydroepiandrosterone SulfateFemaleFlutamideFollicle Stimulating HormoneHirsutismHumansLuteinizing HormoneSpironolactoneTestosterone

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

8150100

Citation

Erenus, M, et al. "Comparison of the Efficacy of Spironolactone Versus Flutamide in the Treatment of Hirsutism." Fertility and Sterility, vol. 61, no. 4, 1994, pp. 613-6.
Erenus M, Gürbüz O, Durmuşoğlu F, et al. Comparison of the efficacy of spironolactone versus flutamide in the treatment of hirsutism. Fertil Steril. 1994;61(4):613-6.
Erenus, M., Gürbüz, O., Durmuşoğlu, F., Demirçay, Z., & Pekin, S. (1994). Comparison of the efficacy of spironolactone versus flutamide in the treatment of hirsutism. Fertility and Sterility, 61(4), 613-6.
Erenus M, et al. Comparison of the Efficacy of Spironolactone Versus Flutamide in the Treatment of Hirsutism. Fertil Steril. 1994;61(4):613-6. PubMed PMID: 8150100.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of the efficacy of spironolactone versus flutamide in the treatment of hirsutism. AU - Erenus,M, AU - Gürbüz,O, AU - Durmuşoğlu,F, AU - Demirçay,Z, AU - Pekin,S, PY - 1994/4/1/pubmed PY - 1994/4/1/medline PY - 1994/4/1/entrez SP - 613 EP - 6 JF - Fertility and sterility JO - Fertil Steril VL - 61 IS - 4 N2 - OBJECTIVE: To compare the efficacy of two antiandrogens, spironolactone and flutamide, in the treatment of hirsutism. PATIENTS, PARTICIPANTS: Twenty women with idiopathic hirsutism were randomized to receive either flutamide or spironolactone. DESIGN: Twenty hirsute women were recruited from patients presenting to the hirsutism clinic in Marmara University, Istanbul. Each patient underwent a complete medical and gynecological examination as well as endocrine profile, hematologic, hepatic, and renal function analyses. Hirsutism scores were determined according to the Ferriman-Gallwey scoring system. These tests were then repeated at 3, 6, and 9 months of therapy. Ten patients received 250 mg of flutamide two times per day, and 10 patients received 100 mg of spironolactone for 9 months. RESULTS: Ferriman-Gallwey scores were decreased significantly in both groups at the end of 9 months. The percent of change in hirsutism scores in flutamide and spironolactone group were as follows: 26.4% and 20.9% at 3 months; 39.5% and 32.9% at 6 months; and 46.4% and 39.6% at 9 months, respectively. There was a trend toward a better response with flutamide that did not achieve significance. None of the hormonal parameters changed significantly during this period of time. Irregular bleeding was observed in five patients (50%) of the spironolactone group, whereas none of the patients in the flutamide group experienced menstrual irregularity. Conversely, dry skin and increased appetite were experienced by two patients (20%) in the flutamide group but not in the spironolactone group. CONCLUSION: These data suggest that both spironolactone and flutamide were similarly effective in treatment of hirsutism, and the pure antiandrogen flutamide is a safe and effective alternative in treatment. SN - 0015-0282 UR - https://www.unboundmedicine.com/medline/citation/8150100/Comparison_of_the_efficacy_of_spironolactone_versus_flutamide_in_the_treatment_of_hirsutism_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(16)56634-5 DB - PRIME DP - Unbound Medicine ER -