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Effect of inhalation of hot humidified air on experimental rhinovirus infection.
JAMA 1994; 271(14):1112-3JAMA

Abstract

OBJECTIVE

Nasal inhalation of steam has been proposed as treatment of viral colds on the assumption that increased intranasal temperature will inhibit replication of rhinovirus (RV). The effect of steam inhalation on RV shedding by infected volunteers was examined in this study.

DESIGN

Randomized controlled trial. Volunteers experimentally infected with RV were treated with machine-generated humidified air, which was either hot (active) or at room temperature (placebo). Viral shedding was assessed over the 4 days following treatment.

SETTING

Local hotel.

PARTICIPANTS

Twenty volunteers from the university community who were susceptible to the challenge virus.

INTERVENTION

Two 30-minute intranasal treatments, the first at 24 hours after inoculation and the second at 48 hours. The temperature of active vapor was 42 degrees C to 44 degrees C and of placebo vapor was 22 degrees C.

MAIN OUTCOME MEASURES

Viral titers in nasal washings on each of 5 days following inoculation.

RESULTS

Mean viral titers prior to the first treatment were 10(1.7) tissue culture infectious doses per milliliter in the active group and 10(1.5) in the placebo group. Mean titers for the next 4 days were 10(1.7), and 10(1.7), 10(1.2), and 10(0.9)/mL in the active group and 10(1.8), 10(1.9), 10(1.6), and 10(0.7)/mL in the placebo group (no significant difference). The proportion of volunteers who shed virus on each day was also similar in the two groups.

CONCLUSION

Two nasal inhalation treatments with steam had no effect on viral shedding in volunteers with experimental RV colds.

Authors+Show Affiliations

Department of Pediatrics, University of Virginia Health Sciences Center, Charlottesville 22908.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8151855

Citation

Hendley, J O., et al. "Effect of Inhalation of Hot Humidified Air On Experimental Rhinovirus Infection." JAMA, vol. 271, no. 14, 1994, pp. 1112-3.
Hendley JO, Abbott RD, Beasley PP, et al. Effect of inhalation of hot humidified air on experimental rhinovirus infection. JAMA. 1994;271(14):1112-3.
Hendley, J. O., Abbott, R. D., Beasley, P. P., & Gwaltney, J. M. (1994). Effect of inhalation of hot humidified air on experimental rhinovirus infection. JAMA, 271(14), pp. 1112-3.
Hendley JO, et al. Effect of Inhalation of Hot Humidified Air On Experimental Rhinovirus Infection. JAMA. 1994 Apr 13;271(14):1112-3. PubMed PMID: 8151855.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of inhalation of hot humidified air on experimental rhinovirus infection. AU - Hendley,J O, AU - Abbott,R D, AU - Beasley,P P, AU - Gwaltney,J M,Jr PY - 1994/4/13/pubmed PY - 2001/3/28/medline PY - 1994/4/13/entrez SP - 1112 EP - 3 JF - JAMA JO - JAMA VL - 271 IS - 14 N2 - OBJECTIVE: Nasal inhalation of steam has been proposed as treatment of viral colds on the assumption that increased intranasal temperature will inhibit replication of rhinovirus (RV). The effect of steam inhalation on RV shedding by infected volunteers was examined in this study. DESIGN: Randomized controlled trial. Volunteers experimentally infected with RV were treated with machine-generated humidified air, which was either hot (active) or at room temperature (placebo). Viral shedding was assessed over the 4 days following treatment. SETTING: Local hotel. PARTICIPANTS: Twenty volunteers from the university community who were susceptible to the challenge virus. INTERVENTION: Two 30-minute intranasal treatments, the first at 24 hours after inoculation and the second at 48 hours. The temperature of active vapor was 42 degrees C to 44 degrees C and of placebo vapor was 22 degrees C. MAIN OUTCOME MEASURES: Viral titers in nasal washings on each of 5 days following inoculation. RESULTS: Mean viral titers prior to the first treatment were 10(1.7) tissue culture infectious doses per milliliter in the active group and 10(1.5) in the placebo group. Mean titers for the next 4 days were 10(1.7), and 10(1.7), 10(1.2), and 10(0.9)/mL in the active group and 10(1.8), 10(1.9), 10(1.6), and 10(0.7)/mL in the placebo group (no significant difference). The proportion of volunteers who shed virus on each day was also similar in the two groups. CONCLUSION: Two nasal inhalation treatments with steam had no effect on viral shedding in volunteers with experimental RV colds. SN - 0098-7484 UR - https://www.unboundmedicine.com/medline/citation/8151855/Effect_of_inhalation_of_hot_humidified_air_on_experimental_rhinovirus_infection_ L2 - https://jamanetwork.com/journals/jama/fullarticle/vol/271/pg/1112 DB - PRIME DP - Unbound Medicine ER -