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[Imported malaria: epidemiological, clinical and therapeutic data of 74 patients during 1 year in the Academic Medical Center, Amsterdam].
Ned Tijdschr Geneeskd. 1994 Apr 02; 138(14):712-6.NT

Abstract

OBJECTIVE

To gain insight into the changes concerning diagnosis and treatment of malaria since 1984.

DESIGN

Retrospective.

SETTING

University Medical Centre, Amsterdam.

METHOD

From October 1991 to October 1992, 74 patients with malaria were diagnosed and treated. Country of origin, plasmodium strain involved, country of infection, interval between return to the Netherlands and onset of symptoms, prophylaxis and therapy, were recorded in every case.

RESULTS

Of these patients 46 (62%) were of European origin; 28 were born in endemic malarial areas. Plasmodium falciparum was diagnosed in 49 of the 74 patients; 88% of these infections were acquired in subsaharan Africa, mainly West Africa. In falciparum malaria, the first symptoms were noticed I-30 days after returning home. P. vivax infections occurred up to 2 years after return. Five of the 49 patients developed severe complications; 2 died. Twenty-six (53%) of the 49 patients had not taken any chemoprophylaxis. The patients with falciparum malaria were treated with sulfadoxine-pyrimethamine or halofantrine, often combined with quinine; the cure rate was 90%.

CONCLUSION

Quinine remains the mainstay in the treatment of complicated falciparum malaria, but is also often used in the initial treatment of uncomplicated malaria. Compliance in malaria prophylaxis still remains a problem.

Authors+Show Affiliations

Driessen SO
Academisch Medisch Centrum, onderafd. Infectieziekten, Tropische Geneeskunde en AIDS, Amsterdam.
Wetsteyn JC
No affiliation info available

MeSH

AdolescentAdultAntimalarialsChildChild, PreschoolFemaleHumansMalaria, FalciparumMalaria, VivaxMaleMiddle AgedNetherlandsPatient ComplianceQuinineRetrospective StudiesTravel

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

dut

PubMed ID

8152512

Citation

Driessen, S O., and J C. Wetsteyn. "[Imported Malaria: Epidemiological, Clinical and Therapeutic Data of 74 Patients During 1 Year in the Academic Medical Center, Amsterdam]." Nederlands Tijdschrift Voor Geneeskunde, vol. 138, no. 14, 1994, pp. 712-6.
Driessen SO, Wetsteyn JC. [Imported malaria: epidemiological, clinical and therapeutic data of 74 patients during 1 year in the Academic Medical Center, Amsterdam]. Ned Tijdschr Geneeskd. 1994;138(14):712-6.
Driessen, S. O., & Wetsteyn, J. C. (1994). [Imported malaria: epidemiological, clinical and therapeutic data of 74 patients during 1 year in the Academic Medical Center, Amsterdam]. Nederlands Tijdschrift Voor Geneeskunde, 138(14), 712-6.
Driessen SO, Wetsteyn JC. [Imported Malaria: Epidemiological, Clinical and Therapeutic Data of 74 Patients During 1 Year in the Academic Medical Center, Amsterdam]. Ned Tijdschr Geneeskd. 1994 Apr 2;138(14):712-6. PubMed PMID: 8152512.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Imported malaria: epidemiological, clinical and therapeutic data of 74 patients during 1 year in the Academic Medical Center, Amsterdam]. AU - Driessen,S O, AU - Wetsteyn,J C, PY - 1994/4/2/pubmed PY - 1994/4/2/medline PY - 1994/4/2/entrez SP - 712 EP - 6 JF - Nederlands tijdschrift voor geneeskunde JO - Ned Tijdschr Geneeskd VL - 138 IS - 14 N2 - OBJECTIVE: To gain insight into the changes concerning diagnosis and treatment of malaria since 1984. DESIGN: Retrospective. SETTING: University Medical Centre, Amsterdam. METHOD: From October 1991 to October 1992, 74 patients with malaria were diagnosed and treated. Country of origin, plasmodium strain involved, country of infection, interval between return to the Netherlands and onset of symptoms, prophylaxis and therapy, were recorded in every case. RESULTS: Of these patients 46 (62%) were of European origin; 28 were born in endemic malarial areas. Plasmodium falciparum was diagnosed in 49 of the 74 patients; 88% of these infections were acquired in subsaharan Africa, mainly West Africa. In falciparum malaria, the first symptoms were noticed I-30 days after returning home. P. vivax infections occurred up to 2 years after return. Five of the 49 patients developed severe complications; 2 died. Twenty-six (53%) of the 49 patients had not taken any chemoprophylaxis. The patients with falciparum malaria were treated with sulfadoxine-pyrimethamine or halofantrine, often combined with quinine; the cure rate was 90%. CONCLUSION: Quinine remains the mainstay in the treatment of complicated falciparum malaria, but is also often used in the initial treatment of uncomplicated malaria. Compliance in malaria prophylaxis still remains a problem. SN - 0028-2162 UR - https://www.unboundmedicine.com/medline/citation/8152512/[Imported_malaria:_epidemiological_clinical_and_therapeutic_data_of_74_patients_during_1_year_in_the_Academic_Medical_Center_Amsterdam]_ L2 - http://www.diseaseinfosearch.org/result/4415 DB - PRIME DP - Unbound Medicine ER -