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Effect of acute increases in serum triiodothyronine on TSH and prolactin responses to TRH, and estimates of pituitary stores of TSH and prolactin in normal subjects and in patients with primary hypothyroidism.
J Clin Endocrinol Metab. 1976 Mar; 42(3):443-58.JC

Abstract

Previous investigators have shown that daily administration of TRH to normal individuals leads to diminishing TSH responses which were believed due to rising serum T3 with subsequent feedback inhibition of the pituitary. Patients with primary hypothyroidism were examined in the present study to test this hypothesis, since their T3 cannot increase after TRH. Bi-daily TRH (100 mug) was given to 4 patients for 3 consecutive days, and repeated on a 4th day following oral T3 (50 mug). TSH and PRL responses were unchanged during these 3days of serial TRH and were unaltered by T3 administration on the fouth day. In 5 other hypothyroid subjects studied before and during 3 consecutive days of T3 administration, TSH but not PRL responses to TRH appeared to decrease slowly but progressively. These observations led us to re-examine TRH responses in normal subjects given T3, since other workers had reported that 50 mug T3 completely abolished TSH response. Responses to TRH in 11 normals on a control day were compared to those observed 1 hour after oral T3. In spite of marked increases in serum T3, there was no significant difference between the mean TSH responses of the two studies.

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Publisher Full Text

Authors

Wartofsky L
No affiliation info available
Dimond RC
No affiliation info available
Noel GL
No affiliation info available
Frantz AG
No affiliation info available
Earll JM
No affiliation info available

MeSH

Clinical Trials as TopicDose-Response Relationship, DrugHumansHypothyroidismMalePituitary GlandPituitary Gland, AnteriorProlactinThyrotropinThyrotropin-Releasing HormoneTriiodothyronine

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

815265

Citation

Wartofsky, L, et al. "Effect of Acute Increases in Serum Triiodothyronine On TSH and Prolactin Responses to TRH, and Estimates of Pituitary Stores of TSH and Prolactin in Normal Subjects and in Patients With Primary Hypothyroidism." The Journal of Clinical Endocrinology and Metabolism, vol. 42, no. 3, 1976, pp. 443-58.
Wartofsky L, Dimond RC, Noel GL, et al. Effect of acute increases in serum triiodothyronine on TSH and prolactin responses to TRH, and estimates of pituitary stores of TSH and prolactin in normal subjects and in patients with primary hypothyroidism. J Clin Endocrinol Metab. 1976;42(3):443-58.
Wartofsky, L., Dimond, R. C., Noel, G. L., Frantz, A. G., & Earll, J. M. (1976). Effect of acute increases in serum triiodothyronine on TSH and prolactin responses to TRH, and estimates of pituitary stores of TSH and prolactin in normal subjects and in patients with primary hypothyroidism. The Journal of Clinical Endocrinology and Metabolism, 42(3), 443-58.
Wartofsky L, et al. Effect of Acute Increases in Serum Triiodothyronine On TSH and Prolactin Responses to TRH, and Estimates of Pituitary Stores of TSH and Prolactin in Normal Subjects and in Patients With Primary Hypothyroidism. J Clin Endocrinol Metab. 1976;42(3):443-58. PubMed PMID: 815265.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of acute increases in serum triiodothyronine on TSH and prolactin responses to TRH, and estimates of pituitary stores of TSH and prolactin in normal subjects and in patients with primary hypothyroidism. AU - Wartofsky,L, AU - Dimond,R C, AU - Noel,G L, AU - Frantz,A G, AU - Earll,J M, PY - 1976/3/1/pubmed PY - 1976/3/1/medline PY - 1976/3/1/entrez SP - 443 EP - 58 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 42 IS - 3 N2 - Previous investigators have shown that daily administration of TRH to normal individuals leads to diminishing TSH responses which were believed due to rising serum T3 with subsequent feedback inhibition of the pituitary. Patients with primary hypothyroidism were examined in the present study to test this hypothesis, since their T3 cannot increase after TRH. Bi-daily TRH (100 mug) was given to 4 patients for 3 consecutive days, and repeated on a 4th day following oral T3 (50 mug). TSH and PRL responses were unchanged during these 3days of serial TRH and were unaltered by T3 administration on the fouth day. In 5 other hypothyroid subjects studied before and during 3 consecutive days of T3 administration, TSH but not PRL responses to TRH appeared to decrease slowly but progressively. These observations led us to re-examine TRH responses in normal subjects given T3, since other workers had reported that 50 mug T3 completely abolished TSH response. Responses to TRH in 11 normals on a control day were compared to those observed 1 hour after oral T3. In spite of marked increases in serum T3, there was no significant difference between the mean TSH responses of the two studies. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/815265/Effect_of_acute_increases_in_serum_triiodothyronine_on_TSH_and_prolactin_responses_to_TRH_and_estimates_of_pituitary_stores_of_TSH_and_prolactin_in_normal_subjects_and_in_patients_with_primary_hypothyroidism_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jcem-42-3-443 DB - PRIME DP - Unbound Medicine ER -
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