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Effect of RG 12525, a new leukotriene antagonist, on pulmonary function of asthmatic adults.
Ann Allergy. 1994 Apr; 72(4):348-52.AA

Abstract

RG 12525 is a new oral leukotriene D4 (LTD4) antagonist with proven activity in animal and human models of leukotriene-induced bronchoconstriction. In this randomized, double-blind, parallel-group, placebo-controlled study the bronchodilator effects of single oral doses of RG 12525 of 25 and 200 mg or placebo were evaluated in 62 adult asthmatic patients. All patients had previously demonstrated 20% reversibility of FEV1 with an inhaled beta-agonist. They had an unmedicated FEV1 less than 80% of predicted value at the time of the study. Bronchodilator activity was assessed by spirometry before and at multiple time points after dosing for eight hours. A single 200-mg dose of RG 12525 of mg resulted in statistically significantly greater increases in mean maximum change above baseline for FEV1 and FEF25-75% than placebo. The peak effect was observed four to five hours after dosing. The RG 12525 dose of 25 mg dose induced better bronchodilation than placebo but the differences were not significant. Adverse clinical experiences or laboratory abnormalities were not noted.

Authors+Show Affiliations

Allergy and Asthma Medical Group and Research Center, San Diego, California.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

8154635

Citation

Welch, M J., et al. "Effect of RG 12525, a New Leukotriene Antagonist, On Pulmonary Function of Asthmatic Adults." Annals of Allergy, vol. 72, no. 4, 1994, pp. 348-52.
Welch MJ, Nelson HS, Paull BR, et al. Effect of RG 12525, a new leukotriene antagonist, on pulmonary function of asthmatic adults. Ann Allergy. 1994;72(4):348-52.
Welch, M. J., Nelson, H. S., Paull, B. R., Smith, J. A., Feiss, G., & Tobey, R. E. (1994). Effect of RG 12525, a new leukotriene antagonist, on pulmonary function of asthmatic adults. Annals of Allergy, 72(4), 348-52.
Welch MJ, et al. Effect of RG 12525, a New Leukotriene Antagonist, On Pulmonary Function of Asthmatic Adults. Ann Allergy. 1994;72(4):348-52. PubMed PMID: 8154635.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of RG 12525, a new leukotriene antagonist, on pulmonary function of asthmatic adults. AU - Welch,M J, AU - Nelson,H S, AU - Paull,B R, AU - Smith,J A, AU - Feiss,G, AU - Tobey,R E, PY - 1994/4/1/pubmed PY - 1994/4/1/medline PY - 1994/4/1/entrez SP - 348 EP - 52 JF - Annals of allergy JO - Ann Allergy VL - 72 IS - 4 N2 - RG 12525 is a new oral leukotriene D4 (LTD4) antagonist with proven activity in animal and human models of leukotriene-induced bronchoconstriction. In this randomized, double-blind, parallel-group, placebo-controlled study the bronchodilator effects of single oral doses of RG 12525 of 25 and 200 mg or placebo were evaluated in 62 adult asthmatic patients. All patients had previously demonstrated 20% reversibility of FEV1 with an inhaled beta-agonist. They had an unmedicated FEV1 less than 80% of predicted value at the time of the study. Bronchodilator activity was assessed by spirometry before and at multiple time points after dosing for eight hours. A single 200-mg dose of RG 12525 of mg resulted in statistically significantly greater increases in mean maximum change above baseline for FEV1 and FEF25-75% than placebo. The peak effect was observed four to five hours after dosing. The RG 12525 dose of 25 mg dose induced better bronchodilation than placebo but the differences were not significant. Adverse clinical experiences or laboratory abnormalities were not noted. SN - 0003-4738 UR - https://www.unboundmedicine.com/medline/citation/8154635/Effect_of_RG_12525_a_new_leukotriene_antagonist_on_pulmonary_function_of_asthmatic_adults_ L2 - https://medlineplus.gov/asthma.html DB - PRIME DP - Unbound Medicine ER -