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Dopamine transporter messenger RNA in Parkinson's disease and control substantia nigra neurons.
Ann Neurol. 1994 Apr; 35(4):494-8.AN

Abstract

Dopamine transporter messenger RNA (mRNA) expression was assessed by in situ hybridization over individual pigmented neurons from the substantia nigra pars compacta in midbrain sections from 7 parkinsonian and 7 age-matched, neurologically normal patients. In the normal control brains, high levels of expression of dopamine transporter mRNA were noted over pigmented neurons in the substantia nigra pars compacta; neurons in the adjacent nucleus paranigralis of the ventral tegmental area displayed less hybridization. Nigra compacta neurons surviving in brains of patients with Parkinson's disease displayed only 57% of the dopamine transporter mRNA hybridization intensity displayed by nigral neurons in normal control brains. The disease-related decrease in the apparent level of dopamine transporter mRNA expression in remaining neurons could reflect neuronal dysfunction. Conceivably, it might also reflect differential vulnerability of those neurons that initially expressed higher levels of this transporter to the insult of parkinsonism.

Authors+Show Affiliations

National Institute on Drug Abuse, Addiction Research Center, Baltimore, MD 21224.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8154880

Citation

Uhl, G R., et al. "Dopamine Transporter Messenger RNA in Parkinson's Disease and Control Substantia Nigra Neurons." Annals of Neurology, vol. 35, no. 4, 1994, pp. 494-8.
Uhl GR, Walther D, Mash D, et al. Dopamine transporter messenger RNA in Parkinson's disease and control substantia nigra neurons. Ann Neurol. 1994;35(4):494-8.
Uhl, G. R., Walther, D., Mash, D., Faucheux, B., & Javoy-Agid, F. (1994). Dopamine transporter messenger RNA in Parkinson's disease and control substantia nigra neurons. Annals of Neurology, 35(4), 494-8.
Uhl GR, et al. Dopamine Transporter Messenger RNA in Parkinson's Disease and Control Substantia Nigra Neurons. Ann Neurol. 1994;35(4):494-8. PubMed PMID: 8154880.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dopamine transporter messenger RNA in Parkinson's disease and control substantia nigra neurons. AU - Uhl,G R, AU - Walther,D, AU - Mash,D, AU - Faucheux,B, AU - Javoy-Agid,F, PY - 1994/4/1/pubmed PY - 1994/4/1/medline PY - 1994/4/1/entrez SP - 494 EP - 8 JF - Annals of neurology JO - Ann Neurol VL - 35 IS - 4 N2 - Dopamine transporter messenger RNA (mRNA) expression was assessed by in situ hybridization over individual pigmented neurons from the substantia nigra pars compacta in midbrain sections from 7 parkinsonian and 7 age-matched, neurologically normal patients. In the normal control brains, high levels of expression of dopamine transporter mRNA were noted over pigmented neurons in the substantia nigra pars compacta; neurons in the adjacent nucleus paranigralis of the ventral tegmental area displayed less hybridization. Nigra compacta neurons surviving in brains of patients with Parkinson's disease displayed only 57% of the dopamine transporter mRNA hybridization intensity displayed by nigral neurons in normal control brains. The disease-related decrease in the apparent level of dopamine transporter mRNA expression in remaining neurons could reflect neuronal dysfunction. Conceivably, it might also reflect differential vulnerability of those neurons that initially expressed higher levels of this transporter to the insult of parkinsonism. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/8154880/Dopamine_transporter_messenger_RNA_in_Parkinson's_disease_and_control_substantia_nigra_neurons_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0364-5134&date=1994&volume=35&issue=4&spage=494 DB - PRIME DP - Unbound Medicine ER -