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Skin irritant reactivity following experimental cumulative irritant contact dermatitis.
Contact Dermatitis. 1994 Jan; 30(1):35-9.CD

Abstract

Despite the frequency of irritant contact dermatitis, very little is known about the duration of barrier function impairment following cumulative irritant contact dermatitis. We studied post-irritation irritant reactivity by assessing the response to SLS irritation in previously irritated sites. Cumulative irritant contact dermatitis was induced on the forearms of 15 volunteers aged 18 to 50 years by repeated occluded application of 0.5% SLS 1 h per day over 3 weeks. 3, 6 and 9 weeks later, previously irritated and unirritated control sites were challenged with 2% SLS under occlusion for 23 h. Irritation was assessed by visual scoring, transepidermal water loss (TEWL) as an indicator of epidermal barrier function, and capacitance as a parameter of epidermal water content. While no difference in irritant reactivity between pre-irritated and unirritated sites was observed 3 weeks following irritant contact dermatitis, there was a significant hyporeactivity of previously irritated skin as expressed by clinical scores, TEWL and capacitance at 6 and 9 weeks. Our results indicate that epidermal barrier function remains altered even 9 weeks after cumulative irritant contact dermatitis. With regard to patch testing, post-irritation hyporeactivity might be a cause of false-negative tests on previously irritated sites.

Authors+Show Affiliations

Department of Dermatology, University of Zurich, Switzerland.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8156760

Citation

Widmer, J, et al. "Skin Irritant Reactivity Following Experimental Cumulative Irritant Contact Dermatitis." Contact Dermatitis, vol. 30, no. 1, 1994, pp. 35-9.
Widmer J, Elsner P, Burg G. Skin irritant reactivity following experimental cumulative irritant contact dermatitis. Contact Dermatitis. 1994;30(1):35-9.
Widmer, J., Elsner, P., & Burg, G. (1994). Skin irritant reactivity following experimental cumulative irritant contact dermatitis. Contact Dermatitis, 30(1), 35-9.
Widmer J, Elsner P, Burg G. Skin Irritant Reactivity Following Experimental Cumulative Irritant Contact Dermatitis. Contact Dermatitis. 1994;30(1):35-9. PubMed PMID: 8156760.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Skin irritant reactivity following experimental cumulative irritant contact dermatitis. AU - Widmer,J, AU - Elsner,P, AU - Burg,G, PY - 1994/1/1/pubmed PY - 1994/1/1/medline PY - 1994/1/1/entrez SP - 35 EP - 9 JF - Contact dermatitis JO - Contact Dermatitis VL - 30 IS - 1 N2 - Despite the frequency of irritant contact dermatitis, very little is known about the duration of barrier function impairment following cumulative irritant contact dermatitis. We studied post-irritation irritant reactivity by assessing the response to SLS irritation in previously irritated sites. Cumulative irritant contact dermatitis was induced on the forearms of 15 volunteers aged 18 to 50 years by repeated occluded application of 0.5% SLS 1 h per day over 3 weeks. 3, 6 and 9 weeks later, previously irritated and unirritated control sites were challenged with 2% SLS under occlusion for 23 h. Irritation was assessed by visual scoring, transepidermal water loss (TEWL) as an indicator of epidermal barrier function, and capacitance as a parameter of epidermal water content. While no difference in irritant reactivity between pre-irritated and unirritated sites was observed 3 weeks following irritant contact dermatitis, there was a significant hyporeactivity of previously irritated skin as expressed by clinical scores, TEWL and capacitance at 6 and 9 weeks. Our results indicate that epidermal barrier function remains altered even 9 weeks after cumulative irritant contact dermatitis. With regard to patch testing, post-irritation hyporeactivity might be a cause of false-negative tests on previously irritated sites. SN - 0105-1873 UR - https://www.unboundmedicine.com/medline/citation/8156760/Skin_irritant_reactivity_following_experimental_cumulative_irritant_contact_dermatitis_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0105-1873&date=1994&volume=30&issue=1&spage=35 DB - PRIME DP - Unbound Medicine ER -