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The effect of vitamin and mineral supplementation on esophageal cytology: results from the Linxian Dysplasia Trial.
Int J Cancer. 1994 Apr 15; 57(2):162-6.IJ

Abstract

The population of Linxian in China has one of the world's highest rates for esophageal/gastric cardia cancer, as well as documented nutritional deficiencies. To determine whether dietary supplementation with a multi-vitamin multi-mineral preparation could reduce the risk of esophageal cancer and favorably influence precursor lesions, 3,318 individuals age 40-69 with cytologically determined grade 1 or grade 2 esophageal dysplasia were randomly assigned to receive either an active multi-vitamin multi-mineral supplement or a placebo. Pills were distributed at monthly visits and incident cancers or deaths were recorded. At 30 and 72 months subsequent to randomization all living participants without a known incident cancer were asked to undergo repeat cytological examination of their esophagus. Based on these procedures participants were classified as having no dysplasia, dysplasia grade 1, dysplasia grade 2 or near cancer dysplasia. Diagnoses of cancer were based on the cytology findings plus available histologic, radiologic and clinical materials. At the end of the study there was little overall difference in cumulative risk of esophageal cancer between those receiving vitamin/mineral supplementation and those receiving placebo. There was, however, a significant increase in reversion to non-dysplastic cytology among the group receiving the active treatment. The odds of not having any dysplasia at the two post-randomization screens was 1.23 times higher in the active treatment group than in the placebo group. Within each treatment group higher categories of dysplasia were associated with higher rates of cancer.

Authors+Show Affiliations

National Cancer Institute, Bethesda, MD.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

8157352

Citation

Mark, S D., et al. "The Effect of Vitamin and Mineral Supplementation On Esophageal Cytology: Results From the Linxian Dysplasia Trial." International Journal of Cancer, vol. 57, no. 2, 1994, pp. 162-6.
Mark SD, Liu SF, Li JY, et al. The effect of vitamin and mineral supplementation on esophageal cytology: results from the Linxian Dysplasia Trial. Int J Cancer. 1994;57(2):162-6.
Mark, S. D., Liu, S. F., Li, J. Y., Gail, M. H., Shen, Q., Dawsey, S. M., Liu, F., Taylor, P. R., Li, B., & Blot, W. J. (1994). The effect of vitamin and mineral supplementation on esophageal cytology: results from the Linxian Dysplasia Trial. International Journal of Cancer, 57(2), 162-6.
Mark SD, et al. The Effect of Vitamin and Mineral Supplementation On Esophageal Cytology: Results From the Linxian Dysplasia Trial. Int J Cancer. 1994 Apr 15;57(2):162-6. PubMed PMID: 8157352.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of vitamin and mineral supplementation on esophageal cytology: results from the Linxian Dysplasia Trial. AU - Mark,S D, AU - Liu,S F, AU - Li,J Y, AU - Gail,M H, AU - Shen,Q, AU - Dawsey,S M, AU - Liu,F, AU - Taylor,P R, AU - Li,B, AU - Blot,W J, PY - 1994/4/15/pubmed PY - 1994/4/15/medline PY - 1994/4/15/entrez SP - 162 EP - 6 JF - International journal of cancer JO - Int J Cancer VL - 57 IS - 2 N2 - The population of Linxian in China has one of the world's highest rates for esophageal/gastric cardia cancer, as well as documented nutritional deficiencies. To determine whether dietary supplementation with a multi-vitamin multi-mineral preparation could reduce the risk of esophageal cancer and favorably influence precursor lesions, 3,318 individuals age 40-69 with cytologically determined grade 1 or grade 2 esophageal dysplasia were randomly assigned to receive either an active multi-vitamin multi-mineral supplement or a placebo. Pills were distributed at monthly visits and incident cancers or deaths were recorded. At 30 and 72 months subsequent to randomization all living participants without a known incident cancer were asked to undergo repeat cytological examination of their esophagus. Based on these procedures participants were classified as having no dysplasia, dysplasia grade 1, dysplasia grade 2 or near cancer dysplasia. Diagnoses of cancer were based on the cytology findings plus available histologic, radiologic and clinical materials. At the end of the study there was little overall difference in cumulative risk of esophageal cancer between those receiving vitamin/mineral supplementation and those receiving placebo. There was, however, a significant increase in reversion to non-dysplastic cytology among the group receiving the active treatment. The odds of not having any dysplasia at the two post-randomization screens was 1.23 times higher in the active treatment group than in the placebo group. Within each treatment group higher categories of dysplasia were associated with higher rates of cancer. SN - 0020-7136 UR - https://www.unboundmedicine.com/medline/citation/8157352/The_effect_of_vitamin_and_mineral_supplementation_on_esophageal_cytology:_results_from_the_Linxian_Dysplasia_Trial_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0020-7136&date=1994&volume=57&issue=2&spage=162 DB - PRIME DP - Unbound Medicine ER -