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The abbreviated 2-1-1 schedule of purified chick embryo cell rabies vaccination for rabies postexposure treatment.

Abstract

During August 1988 to January 1990, the immunogenicity and safety of purified chick embryo cell rabies vaccine (PCEC) given by the conventional and abbreviated regimens in 82 vaccinees moderately to severely exposed to laboratory proven rabid animals were studied. The 16 vaccinees received PCEC six doses as conventional schedule on days 0, 3, 7, 14, 28 and 90, the 11 vaccinees received six doses of PCEC plus human rabies immune globulin (HRIG) on day 0. The 29 vaccinees received an abbreviated schedule of PCEC as two doses on day 0, one dose each on days 7 and 21 and the 26 cases received PCEC abbreviated schedule plus HRIG on day 0. The kinetics of the neutralizing antibodies on days 0, 7, 14, 28, 56, 180 and 365 were studied for comparative purpose. All vaccinees had high antibody levels from day 14 which last longer than a year and were safe after one year follow up. The adverse reactions of the vaccine were mild and self-limited.

Authors+Show Affiliations

Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8160053

Citation

Wasi, C, et al. "The Abbreviated 2-1-1 Schedule of Purified Chick Embryo Cell Rabies Vaccination for Rabies Postexposure Treatment." The Southeast Asian Journal of Tropical Medicine and Public Health, vol. 24, no. 3, 1993, pp. 461-6.
Wasi C, Chaiprasithikul P, Auewarakul P, et al. The abbreviated 2-1-1 schedule of purified chick embryo cell rabies vaccination for rabies postexposure treatment. Southeast Asian J Trop Med Public Health. 1993;24(3):461-6.
Wasi, C., Chaiprasithikul, P., Auewarakul, P., Puthavathana, P., Thongcharoen, P., & Trishnananda, M. (1993). The abbreviated 2-1-1 schedule of purified chick embryo cell rabies vaccination for rabies postexposure treatment. The Southeast Asian Journal of Tropical Medicine and Public Health, 24(3), 461-6.
Wasi C, et al. The Abbreviated 2-1-1 Schedule of Purified Chick Embryo Cell Rabies Vaccination for Rabies Postexposure Treatment. Southeast Asian J Trop Med Public Health. 1993;24(3):461-6. PubMed PMID: 8160053.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The abbreviated 2-1-1 schedule of purified chick embryo cell rabies vaccination for rabies postexposure treatment. AU - Wasi,C, AU - Chaiprasithikul,P, AU - Auewarakul,P, AU - Puthavathana,P, AU - Thongcharoen,P, AU - Trishnananda,M, PY - 1993/9/1/pubmed PY - 1993/9/1/medline PY - 1993/9/1/entrez SP - 461 EP - 6 JF - The Southeast Asian journal of tropical medicine and public health JO - Southeast Asian J Trop Med Public Health VL - 24 IS - 3 N2 - During August 1988 to January 1990, the immunogenicity and safety of purified chick embryo cell rabies vaccine (PCEC) given by the conventional and abbreviated regimens in 82 vaccinees moderately to severely exposed to laboratory proven rabid animals were studied. The 16 vaccinees received PCEC six doses as conventional schedule on days 0, 3, 7, 14, 28 and 90, the 11 vaccinees received six doses of PCEC plus human rabies immune globulin (HRIG) on day 0. The 29 vaccinees received an abbreviated schedule of PCEC as two doses on day 0, one dose each on days 7 and 21 and the 26 cases received PCEC abbreviated schedule plus HRIG on day 0. The kinetics of the neutralizing antibodies on days 0, 7, 14, 28, 56, 180 and 365 were studied for comparative purpose. All vaccinees had high antibody levels from day 14 which last longer than a year and were safe after one year follow up. The adverse reactions of the vaccine were mild and self-limited. SN - 0125-1562 UR - https://www.unboundmedicine.com/medline/citation/8160053/The_abbreviated_2_1_1_schedule_of_purified_chick_embryo_cell_rabies_vaccination_for_rabies_postexposure_treatment_ L2 - http://www.diseaseinfosearch.org/result/6131 DB - PRIME DP - Unbound Medicine ER -