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A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG.
Nat Genet. 1994 Feb; 6(2):146-51.NGen

Abstract

The t(11;22)(q24;q12), present in 85% of Ewing's sarcoma and related tumours, fuses the EWS gene from chromosome 22q12 and the ETS family member, FLI-1. This results in the expression of a chimaeric protein containing the amino-terminal portion of EWS fused to the ETS DNA-binding domain of FLI-1. We have identified a second Ewing's sarcoma translocation, t(21;22)(q22;q12), that fuses EWS to a different ETS family member, the ERG gene located on band 21q22. Identical EWS nucleotide sequences found in the EWS/FLI-1 fusion transcripts are fused to portions of ERG encoding an ETS DNA-binding domain resulting in expression of a hybrid EWS/ERG protein. These findings suggest that fusion of EWS to different members of the ETS family of transcription factor genes may result in the expression of similar disease phenotypes.

Authors+Show Affiliations

Department of Pathology and Laboratory Medicine, Childrens Hospital of Los Angeles/University of Southern California 90027.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8162068

Citation

Sorensen, P H., et al. "A Second Ewing's Sarcoma Translocation, T(21;22), Fuses the EWS Gene to Another ETS-family Transcription Factor, ERG." Nature Genetics, vol. 6, no. 2, 1994, pp. 146-51.
Sorensen PH, Lessnick SL, Lopez-Terrada D, et al. A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG. Nat Genet. 1994;6(2):146-51.
Sorensen, P. H., Lessnick, S. L., Lopez-Terrada, D., Liu, X. F., Triche, T. J., & Denny, C. T. (1994). A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG. Nature Genetics, 6(2), 146-51.
Sorensen PH, et al. A Second Ewing's Sarcoma Translocation, T(21;22), Fuses the EWS Gene to Another ETS-family Transcription Factor, ERG. Nat Genet. 1994;6(2):146-51. PubMed PMID: 8162068.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG. AU - Sorensen,P H, AU - Lessnick,S L, AU - Lopez-Terrada,D, AU - Liu,X F, AU - Triche,T J, AU - Denny,C T, PY - 1994/2/1/pubmed PY - 1994/2/1/medline PY - 1994/2/1/entrez SP - 146 EP - 51 JF - Nature genetics JO - Nat Genet VL - 6 IS - 2 N2 - The t(11;22)(q24;q12), present in 85% of Ewing's sarcoma and related tumours, fuses the EWS gene from chromosome 22q12 and the ETS family member, FLI-1. This results in the expression of a chimaeric protein containing the amino-terminal portion of EWS fused to the ETS DNA-binding domain of FLI-1. We have identified a second Ewing's sarcoma translocation, t(21;22)(q22;q12), that fuses EWS to a different ETS family member, the ERG gene located on band 21q22. Identical EWS nucleotide sequences found in the EWS/FLI-1 fusion transcripts are fused to portions of ERG encoding an ETS DNA-binding domain resulting in expression of a hybrid EWS/ERG protein. These findings suggest that fusion of EWS to different members of the ETS family of transcription factor genes may result in the expression of similar disease phenotypes. SN - 1061-4036 UR - https://www.unboundmedicine.com/medline/citation/8162068/A_second_Ewing's_sarcoma_translocation_t_21 L2 - https://doi.org/10.1038/ng0294-146 DB - PRIME DP - Unbound Medicine ER -