Tags

Type your tag names separated by a space and hit enter

Hypopigmented mycosis fungoides.
Arch Dermatol. 1994 Apr; 130(4):476-80.AD

Abstract

BACKGROUND

Only five cases of purely macular hypopigmented mycosis fungoides have been published in the literature. These patients all had clinical evidence of disease 7 months to 10 years prior to histologic diagnosis, suggesting that this clinical presentation of mycosis fungoides is easily misdiagnosed.

OBSERVATIONS

Three African-American males, ages 9, 15, and 22 years, were found to have mycosis fungoides on evaluation of skin biopsy specimens after initially being clinically diagnosed with, and treated for, pityriasis alba. All three had typical histopathologic changes and cell marker studies showing a relative loss of the CD7 antigen, which is normally present on the majority of T cells. One patient who was treated with methoxsalen plus UV light (PUVA) therapy had clearance of his disease clinically and histologically.

CONCLUSION

From the literature, it would appear that macular hypopigmented mycosis fungoides is exceptionally rare. This perceived rarity may be inaccurate due to either relative underreporting, incorrect diagnoses, or both. From the eight patients now reported to date, it may be said that hypopigmented mycosis fungoides may be seen in nonwhite individuals and more often than not, has onset before age 20 years.

Authors+Show Affiliations

Department of Dermatology, Johns Hopkins Medical Institutions, Baltimore, Md.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

8166485

Citation

Whitmore, S E., et al. "Hypopigmented Mycosis Fungoides." Archives of Dermatology, vol. 130, no. 4, 1994, pp. 476-80.
Whitmore SE, Simmons-O'Brien E, Rotter FS. Hypopigmented mycosis fungoides. Arch Dermatol. 1994;130(4):476-80.
Whitmore, S. E., Simmons-O'Brien, E., & Rotter, F. S. (1994). Hypopigmented mycosis fungoides. Archives of Dermatology, 130(4), 476-80.
Whitmore SE, Simmons-O'Brien E, Rotter FS. Hypopigmented Mycosis Fungoides. Arch Dermatol. 1994;130(4):476-80. PubMed PMID: 8166485.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypopigmented mycosis fungoides. AU - Whitmore,S E, AU - Simmons-O'Brien,E, AU - Rotter,F S, PY - 1994/4/1/pubmed PY - 1994/4/1/medline PY - 1994/4/1/entrez SP - 476 EP - 80 JF - Archives of dermatology JO - Arch Dermatol VL - 130 IS - 4 N2 - BACKGROUND: Only five cases of purely macular hypopigmented mycosis fungoides have been published in the literature. These patients all had clinical evidence of disease 7 months to 10 years prior to histologic diagnosis, suggesting that this clinical presentation of mycosis fungoides is easily misdiagnosed. OBSERVATIONS: Three African-American males, ages 9, 15, and 22 years, were found to have mycosis fungoides on evaluation of skin biopsy specimens after initially being clinically diagnosed with, and treated for, pityriasis alba. All three had typical histopathologic changes and cell marker studies showing a relative loss of the CD7 antigen, which is normally present on the majority of T cells. One patient who was treated with methoxsalen plus UV light (PUVA) therapy had clearance of his disease clinically and histologically. CONCLUSION: From the literature, it would appear that macular hypopigmented mycosis fungoides is exceptionally rare. This perceived rarity may be inaccurate due to either relative underreporting, incorrect diagnoses, or both. From the eight patients now reported to date, it may be said that hypopigmented mycosis fungoides may be seen in nonwhite individuals and more often than not, has onset before age 20 years. SN - 0003-987X UR - https://www.unboundmedicine.com/medline/citation/8166485/Hypopigmented_mycosis_fungoides_ DB - PRIME DP - Unbound Medicine ER -