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Effect of sterilization and storage treatments on screw pullout strength in human allograft bone.
Clin Orthop Relat Res 1994; (302):290-6CO

Abstract

Many conflicting studies have been performed evaluating the effects of sterilization and storage treatments on the mechanical properties of allograft bone. In the current study, four right and left matched, sterile, deep-frozen, tibial pairs from human donors with an average age of 32 years were tested. One tibia from each pair served as a matched control for the opposite side. Each tibia was cut into four equal segments. One segment of each tibia underwent no treatment; the other three underwent one of the following treatments: irradiation, freeze drying, or ethylene oxide (ETO). Screw pullout tests were performed using four 3.5-mm cortical screws per segment. Sixteen screw pullout tests were performed for each allograft treatment. The freeze-dried specimens required significantly less force for screw pullout. The screw pullout force for the irradiated specimens and the ETO specimens did not significantly differ from their controls. These results indicate that freeze drying affected screw pullout strength. This method of processing should be questioned for structural allografts in which screw fixation is mandatory. The use of irradiation or ETO for sterilization may not have an adverse effect on screw pullout strength.

Authors+Show Affiliations

Biomechanics Laboratory, Harborview Medical Center, Seattle, WA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

8168316

Citation

Simonian, P T., et al. "Effect of Sterilization and Storage Treatments On Screw Pullout Strength in Human Allograft Bone." Clinical Orthopaedics and Related Research, 1994, pp. 290-6.
Simonian PT, Conrad EU, Chapman JR, et al. Effect of sterilization and storage treatments on screw pullout strength in human allograft bone. Clin Orthop Relat Res. 1994.
Simonian, P. T., Conrad, E. U., Chapman, J. R., Harrington, R. M., & Chansky, H. A. (1994). Effect of sterilization and storage treatments on screw pullout strength in human allograft bone. Clinical Orthopaedics and Related Research, (302), pp. 290-6.
Simonian PT, et al. Effect of Sterilization and Storage Treatments On Screw Pullout Strength in Human Allograft Bone. Clin Orthop Relat Res. 1994;(302)290-6. PubMed PMID: 8168316.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of sterilization and storage treatments on screw pullout strength in human allograft bone. AU - Simonian,P T, AU - Conrad,E U, AU - Chapman,J R, AU - Harrington,R M, AU - Chansky,H A, PY - 1994/5/1/pubmed PY - 1994/5/1/medline PY - 1994/5/1/entrez SP - 290 EP - 6 JF - Clinical orthopaedics and related research JO - Clin. Orthop. Relat. Res. IS - 302 N2 - Many conflicting studies have been performed evaluating the effects of sterilization and storage treatments on the mechanical properties of allograft bone. In the current study, four right and left matched, sterile, deep-frozen, tibial pairs from human donors with an average age of 32 years were tested. One tibia from each pair served as a matched control for the opposite side. Each tibia was cut into four equal segments. One segment of each tibia underwent no treatment; the other three underwent one of the following treatments: irradiation, freeze drying, or ethylene oxide (ETO). Screw pullout tests were performed using four 3.5-mm cortical screws per segment. Sixteen screw pullout tests were performed for each allograft treatment. The freeze-dried specimens required significantly less force for screw pullout. The screw pullout force for the irradiated specimens and the ETO specimens did not significantly differ from their controls. These results indicate that freeze drying affected screw pullout strength. This method of processing should be questioned for structural allografts in which screw fixation is mandatory. The use of irradiation or ETO for sterilization may not have an adverse effect on screw pullout strength. SN - 0009-921X UR - https://www.unboundmedicine.com/medline/citation/8168316/Effect_of_sterilization_and_storage_treatments_on_screw_pullout_strength_in_human_allograft_bone_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=8168316.ui DB - PRIME DP - Unbound Medicine ER -