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[Inhibition of non-cytotoxic histamine liberation from isolated rat mast cells by antihistaminic preparations].
Biull Eksp Biol Med. 1978 Oct; 86(10):471-4.BE

Abstract

Phenothiazines (chlorpromazine and promethazine) and antihistaminic quinuclidine derivatives [phencarol, quinuclidyl-3-di-(o-tolyl) carbinol, hydrochloride quinuclidyl-3-di-(o-methoxyphenyl) carbinol--HQMC] at concentrations preceding the histamine-releasing ones inhibited the compound 48/80-induced histamine release from the isolated rat mast cells. HQMC inhibited histamine release induced by selective liberators (compound 48/80, MCD-peptide, specific antigen), but potentiated histamine release induced by nonselective liberators (chlorpromazine, tryton X-100). The inhibition by HQMC of histamine release induced by compound 48/80 increased during 1 min and was reversible. The inhibitory effect of all the compounds tested was partially counteracted by glucose.

Authors

Gushchin IS
No affiliation info available
Kaminka ME
No affiliation info available
Deriugin IL
No affiliation info available

MeSH

AnimalsBenzhydryl CompoundsChlorpromazineDrug InteractionsFemaleHistamine AntagonistsHistamine H1 AntagonistsHistamine ReleaseMast CellsPeptidesPolyethylene GlycolsPromethazineQuinuclidinesRatsp-Methoxy-N-methylphenethylamine

Pub Type(s)

Comparative Study
Journal Article

Language

rus

PubMed ID

81693

Citation

Gushchin, I S., et al. "[Inhibition of Non-cytotoxic Histamine Liberation From Isolated Rat Mast Cells By Antihistaminic Preparations]." Biulleten' Eksperimental'noi Biologii I Meditsiny, vol. 86, no. 10, 1978, pp. 471-4.
Gushchin IS, Kaminka ME, Deriugin IL. [Inhibition of non-cytotoxic histamine liberation from isolated rat mast cells by antihistaminic preparations]. Biull Eksp Biol Med. 1978;86(10):471-4.
Gushchin, I. S., Kaminka, M. E., & Deriugin, I. L. (1978). [Inhibition of non-cytotoxic histamine liberation from isolated rat mast cells by antihistaminic preparations]. Biulleten' Eksperimental'noi Biologii I Meditsiny, 86(10), 471-4.
Gushchin IS, Kaminka ME, Deriugin IL. [Inhibition of Non-cytotoxic Histamine Liberation From Isolated Rat Mast Cells By Antihistaminic Preparations]. Biull Eksp Biol Med. 1978;86(10):471-4. PubMed PMID: 81693.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Inhibition of non-cytotoxic histamine liberation from isolated rat mast cells by antihistaminic preparations]. AU - Gushchin,I S, AU - Kaminka,M E, AU - Deriugin,I L, PY - 1978/10/1/pubmed PY - 1978/10/1/medline PY - 1978/10/1/entrez SP - 471 EP - 4 JF - Biulleten' eksperimental'noi biologii i meditsiny JO - Biull Eksp Biol Med VL - 86 IS - 10 N2 - Phenothiazines (chlorpromazine and promethazine) and antihistaminic quinuclidine derivatives [phencarol, quinuclidyl-3-di-(o-tolyl) carbinol, hydrochloride quinuclidyl-3-di-(o-methoxyphenyl) carbinol--HQMC] at concentrations preceding the histamine-releasing ones inhibited the compound 48/80-induced histamine release from the isolated rat mast cells. HQMC inhibited histamine release induced by selective liberators (compound 48/80, MCD-peptide, specific antigen), but potentiated histamine release induced by nonselective liberators (chlorpromazine, tryton X-100). The inhibition by HQMC of histamine release induced by compound 48/80 increased during 1 min and was reversible. The inhibitory effect of all the compounds tested was partially counteracted by glucose. SN - 0365-9615 UR - https://www.unboundmedicine.com/medline/citation/81693/[Inhibition_of_non_cytotoxic_histamine_liberation_from_isolated_rat_mast_cells_by_antihistaminic_preparations]_ DB - PRIME DP - Unbound Medicine ER -