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Bone mineral density and history of oral contraceptive use.
J Reprod Med 1994; 39(2):105-9JR

Abstract

To examine the relationship between oral contraceptive (OC) use and bone mineral density (BMD), we conducted a cross-sectional study on 352 white, nonsmoking, perimenopausal women aged 40-54 years. We measured bone mineral density of lumbar vertebrae 2-4 with dual photon absorptiometry and mid-radius and distal radius with single photon absorptiometry. After controlling for age, body mass, current physical activity, current calcium intake and history of breastfeeding, our analysis did not find substantial differences in BMD at any site between OC ever users and never users. However, OC ever users had slightly higher lumbar BMD among premenopausal women. No significant association was identified between recency of OC use and BMD. The results of our study suggest that when other factors are accounted for, OC use is not strongly associated with BMD among perimenopausal women, although we cannot exclude a slight beneficial effect.

Authors+Show Affiliations

Family Health International, Research Triangle Park Branch, Durham, NC 27709.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8169923

Citation

Fortney, J A., et al. "Bone Mineral Density and History of Oral Contraceptive Use." The Journal of Reproductive Medicine, vol. 39, no. 2, 1994, pp. 105-9.
Fortney JA, Feldblum PJ, Talmage RV, et al. Bone mineral density and history of oral contraceptive use. J Reprod Med. 1994;39(2):105-9.
Fortney, J. A., Feldblum, P. J., Talmage, R. V., Zhang, J., & Godwin, S. E. (1994). Bone mineral density and history of oral contraceptive use. The Journal of Reproductive Medicine, 39(2), pp. 105-9.
Fortney JA, et al. Bone Mineral Density and History of Oral Contraceptive Use. J Reprod Med. 1994;39(2):105-9. PubMed PMID: 8169923.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bone mineral density and history of oral contraceptive use. AU - Fortney,J A, AU - Feldblum,P J, AU - Talmage,R V, AU - Zhang,J, AU - Godwin,S E, PY - 1994/2/1/pubmed PY - 1994/2/1/medline PY - 1994/2/1/entrez KW - Americas KW - Biology KW - Contraception KW - Contraceptive Methods--side effects KW - Contraceptive Usage KW - Developed Countries KW - Family Planning KW - North America KW - North Carolina KW - Northern America KW - Oral Contraceptives--side effects KW - Physiology KW - Research Report KW - Risk Assessment KW - Skeletal Effects KW - United States SP - 105 EP - 9 JF - The Journal of reproductive medicine JO - J Reprod Med VL - 39 IS - 2 N2 - To examine the relationship between oral contraceptive (OC) use and bone mineral density (BMD), we conducted a cross-sectional study on 352 white, nonsmoking, perimenopausal women aged 40-54 years. We measured bone mineral density of lumbar vertebrae 2-4 with dual photon absorptiometry and mid-radius and distal radius with single photon absorptiometry. After controlling for age, body mass, current physical activity, current calcium intake and history of breastfeeding, our analysis did not find substantial differences in BMD at any site between OC ever users and never users. However, OC ever users had slightly higher lumbar BMD among premenopausal women. No significant association was identified between recency of OC use and BMD. The results of our study suggest that when other factors are accounted for, OC use is not strongly associated with BMD among perimenopausal women, although we cannot exclude a slight beneficial effect. SN - 0024-7758 UR - https://www.unboundmedicine.com/medline/citation/8169923/Bone_mineral_density_and_history_of_oral_contraceptive_use_ L2 - https://medlineplus.gov/bonedensity.html DB - PRIME DP - Unbound Medicine ER -