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Measles vaccine failures: lack of sustained measles-specific immunoglobulin G responses in revaccinated adolescents and young adults.
Pediatr Infect Dis J. 1994 Jan; 13(1):34-8.PI

Abstract

The measles-specific antibody responses of seronegative adolescents and young adults were evaluated after revaccination. Of 1650 previously vaccinated healthy volunteers between the ages of 10 and 30 years, 4.4% were found to be seronegative for measles antibodies and 9.9% had equivocal titers. Seronegative volunteers were revaccinated to measles and followed serially for development of measles-specific IgG. Of 43 subjects followed for at least 1 year, only 58% developed and maintained positive antibody titers; 12% never developed positive titers and 30% initially developed titers that fell below positive levels within 1 year. The peak titers achieved by those subjects who responded transiently were lower than those achieved by subjects who developed sustained responses. Thus even after the recommended two dose schedule of the current measles vaccine, some adolescents and young adults lack protective titers of measles-specific antibody.

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Authors+Show Affiliations

Cohn ML
Department of Pediatrics, Georgetown University Medical Center, Washington, DC 20007.
Robinson ED
No affiliation info available
Faerber M
No affiliation info available
Thomas D
No affiliation info available
Geyer S
No affiliation info available
Peters S
No affiliation info available
Martin M
No affiliation info available
Martin A
No affiliation info available
Sobel D
No affiliation info available
Jones R
No affiliation info available

MeSH

AdolescentAdultAntibodies, ViralChildDrug CombinationsFemaleHumansImmunization, SecondaryImmunoglobulin GMaleMeaslesMeasles VaccineMeasles virusMeasles-Mumps-Rubella VaccineMumps VaccineRubella VaccineTreatment Failure

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8170730

Citation

Cohn, M L., et al. "Measles Vaccine Failures: Lack of Sustained Measles-specific Immunoglobulin G Responses in Revaccinated Adolescents and Young Adults." The Pediatric Infectious Disease Journal, vol. 13, no. 1, 1994, pp. 34-8.
Cohn ML, Robinson ED, Faerber M, et al. Measles vaccine failures: lack of sustained measles-specific immunoglobulin G responses in revaccinated adolescents and young adults. Pediatr Infect Dis J. 1994;13(1):34-8.
Cohn, M. L., Robinson, E. D., Faerber, M., Thomas, D., Geyer, S., Peters, S., Martin, M., Martin, A., Sobel, D., & Jones, R. (1994). Measles vaccine failures: lack of sustained measles-specific immunoglobulin G responses in revaccinated adolescents and young adults. The Pediatric Infectious Disease Journal, 13(1), 34-8.
Cohn ML, et al. Measles Vaccine Failures: Lack of Sustained Measles-specific Immunoglobulin G Responses in Revaccinated Adolescents and Young Adults. Pediatr Infect Dis J. 1994;13(1):34-8. PubMed PMID: 8170730.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Measles vaccine failures: lack of sustained measles-specific immunoglobulin G responses in revaccinated adolescents and young adults. A1 - Cohn,M L, AU - Robinson,E D, AU - Faerber,M, AU - Thomas,D, AU - Geyer,S, AU - Peters,S, AU - Martin,M, AU - Martin,A, AU - Sobel,D, AU - Jones,R, PY - 1994/1/1/pubmed PY - 1994/1/1/medline PY - 1994/1/1/entrez SP - 34 EP - 8 JF - The Pediatric infectious disease journal JO - Pediatr Infect Dis J VL - 13 IS - 1 N2 - The measles-specific antibody responses of seronegative adolescents and young adults were evaluated after revaccination. Of 1650 previously vaccinated healthy volunteers between the ages of 10 and 30 years, 4.4% were found to be seronegative for measles antibodies and 9.9% had equivocal titers. Seronegative volunteers were revaccinated to measles and followed serially for development of measles-specific IgG. Of 43 subjects followed for at least 1 year, only 58% developed and maintained positive antibody titers; 12% never developed positive titers and 30% initially developed titers that fell below positive levels within 1 year. The peak titers achieved by those subjects who responded transiently were lower than those achieved by subjects who developed sustained responses. Thus even after the recommended two dose schedule of the current measles vaccine, some adolescents and young adults lack protective titers of measles-specific antibody. SN - 0891-3668 UR - https://www.unboundmedicine.com/medline/citation/8170730/Measles_vaccine_failures:_lack_of_sustained_measles_specific_immunoglobulin_G_responses_in_revaccinated_adolescents_and_young_adults_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=8170730.ui DB - PRIME DP - Unbound Medicine ER -