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Serum concentrations of carboxyterminal cross-linked telopeptide of type I collagen (ICTP), serum tartrate resistant acid phosphatase, and serum levels of intact parathyroid hormone in parathyroid hyperfunction.
Scand J Clin Lab Invest. 1994 Feb; 54(1):11-5.SJ

Abstract

We have studied the levels of a new biochemical marker of bone resorption, carboxyterminal cross-linked telopeptide of type I collagen (ICTP), in 26 healthy control subjects, 15 patients with primary hyperparathyroidism (PHPT) and 17 patients with secondary hyperparathyroidism (secondary HPT). Levels of ICTP in PHPT and secondary HPT have been correlated with those of serum tartrate resistant acid phosphatase (TRAP), another biochemical marker of bone turnover, and with serum levels of intact parathyroid hormone (iPTH). The ICTP levels of the control group were 2.07 +/- 0.58 micrograms l-1, n = 26, range 1.3-3.2. They were independent of sex and age in the studied age range (30-62 years). The ICTP levels of PHPT patients were 3.5 +/- 3.5 micrograms l-1, mean +/- SD, range 0.5-12.2 micrograms l-1, significantly higher than those of control subjects (p < 0.05). We found a significant linear correlation between values of ICTP and iPTH levels (p < 0.01), between values of ICTP and serum activity of TRAP (p < 0.01) and between iPTH and TRAP levels (p < 0.01) in patients with PHPT. The ICTP levels in patients with secondary HPT were higher than those of patients with PHPT, 46 +/- 37 micrograms l-1, range 12-167 micrograms l-1 (p < 0.001) due to the impaired renal clearance of this peptide. We did not find a significant linear correlation between values of ICTP and iPTH levels in the serum of patients with secondary HPT, although we found a significant correlation between levels of ICTP and levels of TRAP, both biochemical markers of bone turnover.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Unidad Metabólica, Fundación Jiménez Díaz, Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8171266

Citation

De la Piedra, C, et al. "Serum Concentrations of Carboxyterminal Cross-linked Telopeptide of Type I Collagen (ICTP), Serum Tartrate Resistant Acid Phosphatase, and Serum Levels of Intact Parathyroid Hormone in Parathyroid Hyperfunction." Scandinavian Journal of Clinical and Laboratory Investigation, vol. 54, no. 1, 1994, pp. 11-5.
De la Piedra C, Díaz Martín MA, Díaz Diego EM, et al. Serum concentrations of carboxyterminal cross-linked telopeptide of type I collagen (ICTP), serum tartrate resistant acid phosphatase, and serum levels of intact parathyroid hormone in parathyroid hyperfunction. Scand J Clin Lab Invest. 1994;54(1):11-5.
De la Piedra, C., Díaz Martín, M. A., Díaz Diego, E. M., López Gavilanes, E., González Parra, E., Caramelo, C., & Rapado, A. (1994). Serum concentrations of carboxyterminal cross-linked telopeptide of type I collagen (ICTP), serum tartrate resistant acid phosphatase, and serum levels of intact parathyroid hormone in parathyroid hyperfunction. Scandinavian Journal of Clinical and Laboratory Investigation, 54(1), 11-5.
De la Piedra C, et al. Serum Concentrations of Carboxyterminal Cross-linked Telopeptide of Type I Collagen (ICTP), Serum Tartrate Resistant Acid Phosphatase, and Serum Levels of Intact Parathyroid Hormone in Parathyroid Hyperfunction. Scand J Clin Lab Invest. 1994;54(1):11-5. PubMed PMID: 8171266.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum concentrations of carboxyterminal cross-linked telopeptide of type I collagen (ICTP), serum tartrate resistant acid phosphatase, and serum levels of intact parathyroid hormone in parathyroid hyperfunction. AU - De la Piedra,C, AU - Díaz Martín,M A, AU - Díaz Diego,E M, AU - López Gavilanes,E, AU - González Parra,E, AU - Caramelo,C, AU - Rapado,A, PY - 1994/2/1/pubmed PY - 1994/2/1/medline PY - 1994/2/1/entrez SP - 11 EP - 5 JF - Scandinavian journal of clinical and laboratory investigation JO - Scand J Clin Lab Invest VL - 54 IS - 1 N2 - We have studied the levels of a new biochemical marker of bone resorption, carboxyterminal cross-linked telopeptide of type I collagen (ICTP), in 26 healthy control subjects, 15 patients with primary hyperparathyroidism (PHPT) and 17 patients with secondary hyperparathyroidism (secondary HPT). Levels of ICTP in PHPT and secondary HPT have been correlated with those of serum tartrate resistant acid phosphatase (TRAP), another biochemical marker of bone turnover, and with serum levels of intact parathyroid hormone (iPTH). The ICTP levels of the control group were 2.07 +/- 0.58 micrograms l-1, n = 26, range 1.3-3.2. They were independent of sex and age in the studied age range (30-62 years). The ICTP levels of PHPT patients were 3.5 +/- 3.5 micrograms l-1, mean +/- SD, range 0.5-12.2 micrograms l-1, significantly higher than those of control subjects (p < 0.05). We found a significant linear correlation between values of ICTP and iPTH levels (p < 0.01), between values of ICTP and serum activity of TRAP (p < 0.01) and between iPTH and TRAP levels (p < 0.01) in patients with PHPT. The ICTP levels in patients with secondary HPT were higher than those of patients with PHPT, 46 +/- 37 micrograms l-1, range 12-167 micrograms l-1 (p < 0.001) due to the impaired renal clearance of this peptide. We did not find a significant linear correlation between values of ICTP and iPTH levels in the serum of patients with secondary HPT, although we found a significant correlation between levels of ICTP and levels of TRAP, both biochemical markers of bone turnover.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0036-5513 UR - https://www.unboundmedicine.com/medline/citation/8171266/Serum_concentrations_of_carboxyterminal_cross_linked_telopeptide_of_type_I_collagen__ICTP__serum_tartrate_resistant_acid_phosphatase_and_serum_levels_of_intact_parathyroid_hormone_in_parathyroid_hyperfunction_ L2 - https://www.tandfonline.com/doi/full/10.3109/00365519409086504 DB - PRIME DP - Unbound Medicine ER -