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Adenosine protects against attenuation of flow reserve and myocardial function after coronary occlusion and reperfusion.
Am Heart J. 1994 May; 127(5):1201-11.AH

Abstract

Total coronary artery occlusion and reperfusion result in attenuation of coronary blood flow reserve, regional myocardial dysfunction, and myocardial leukocyte infiltration. To examine the effects of intracoronary adenosine on these occlusion and reperfusion-induced perturbations, we subjected 14 dogs to total left anterior descending (LAD) coronary artery occlusion (1 hour) and reperfusion (1 hour). Seven dogs received adenosine (3.75 mg/min into the LAD distal to the occlusion) over a 1-hour period starting 5 minutes before reperfusion, and the remaining seven dogs received saline solution. One dog in each group died of ventricular fibrillation during coronary artery occlusion. Coronary flow reserve, measured as peak reactive hyperemia (10 and 20 seconds of total coronary artery occlusion) and peak coronary blood flow response to acetylcholine (0.01 to 1.0 micrograms) and nitroglycerin (5 to 25 micrograms), was impaired in the LAD region after LAD occlusion and reperfusion in the saline-treated dogs (all p < 0.01 vs before occlusion and reperfusion); LAD regional myocardial shortening fraction measured by ultrasonic crystals was also diminished after occlusion and reperfusion in saline-treated dogs (-5% +/- 1% vs 12% +/- 2%; p < 0.02). The adenosine-treated dogs showed total protection against loss of coronary flow reserve (peak reactive hyperemia and blood flow increase in response to acetylcholine and nitroglycerin; all p values not significant vs before LAD occlusion and reperfusion). LAD regional myocardial shortening fraction was also preserved in adenosine-treated dogs (9% +/- 2% vs 14% +/- 2%; p not significant). Myocardial myeloperoxidase activity, measured as an index of myocardial leukocyte infiltration, was greater (p < 0.02) in the LAD ischemic-reperfused regions than in nonischemic circumflex regions in the saline-treated dogs. A similar difference in myeloperoxidase activities in the reperfused and control regions was not observed in the adenosine-treated dogs. Thus adenosine protects against loss of coronary flow reserve and regional myocardial function in dogs subjected to coronary artery occlusion and reperfusion.

Authors+Show Affiliations

Department of Medicine, University of Florida College of Medicine, Gainesville 32610-0277.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8172047

Citation

Nichols, W W., et al. "Adenosine Protects Against Attenuation of Flow Reserve and Myocardial Function After Coronary Occlusion and Reperfusion." American Heart Journal, vol. 127, no. 5, 1994, pp. 1201-11.
Nichols WW, Nicolini FA, Yang BC, et al. Adenosine protects against attenuation of flow reserve and myocardial function after coronary occlusion and reperfusion. Am Heart J. 1994;127(5):1201-11.
Nichols, W. W., Nicolini, F. A., Yang, B. C., Henson, K., Stechmiller, J. K., & Mehta, J. L. (1994). Adenosine protects against attenuation of flow reserve and myocardial function after coronary occlusion and reperfusion. American Heart Journal, 127(5), 1201-11.
Nichols WW, et al. Adenosine Protects Against Attenuation of Flow Reserve and Myocardial Function After Coronary Occlusion and Reperfusion. Am Heart J. 1994;127(5):1201-11. PubMed PMID: 8172047.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adenosine protects against attenuation of flow reserve and myocardial function after coronary occlusion and reperfusion. AU - Nichols,W W, AU - Nicolini,F A, AU - Yang,B C, AU - Henson,K, AU - Stechmiller,J K, AU - Mehta,J L, PY - 1994/5/1/pubmed PY - 1994/5/1/medline PY - 1994/5/1/entrez SP - 1201 EP - 11 JF - American heart journal JO - Am Heart J VL - 127 IS - 5 N2 - Total coronary artery occlusion and reperfusion result in attenuation of coronary blood flow reserve, regional myocardial dysfunction, and myocardial leukocyte infiltration. To examine the effects of intracoronary adenosine on these occlusion and reperfusion-induced perturbations, we subjected 14 dogs to total left anterior descending (LAD) coronary artery occlusion (1 hour) and reperfusion (1 hour). Seven dogs received adenosine (3.75 mg/min into the LAD distal to the occlusion) over a 1-hour period starting 5 minutes before reperfusion, and the remaining seven dogs received saline solution. One dog in each group died of ventricular fibrillation during coronary artery occlusion. Coronary flow reserve, measured as peak reactive hyperemia (10 and 20 seconds of total coronary artery occlusion) and peak coronary blood flow response to acetylcholine (0.01 to 1.0 micrograms) and nitroglycerin (5 to 25 micrograms), was impaired in the LAD region after LAD occlusion and reperfusion in the saline-treated dogs (all p < 0.01 vs before occlusion and reperfusion); LAD regional myocardial shortening fraction measured by ultrasonic crystals was also diminished after occlusion and reperfusion in saline-treated dogs (-5% +/- 1% vs 12% +/- 2%; p < 0.02). The adenosine-treated dogs showed total protection against loss of coronary flow reserve (peak reactive hyperemia and blood flow increase in response to acetylcholine and nitroglycerin; all p values not significant vs before LAD occlusion and reperfusion). LAD regional myocardial shortening fraction was also preserved in adenosine-treated dogs (9% +/- 2% vs 14% +/- 2%; p not significant). Myocardial myeloperoxidase activity, measured as an index of myocardial leukocyte infiltration, was greater (p < 0.02) in the LAD ischemic-reperfused regions than in nonischemic circumflex regions in the saline-treated dogs. A similar difference in myeloperoxidase activities in the reperfused and control regions was not observed in the adenosine-treated dogs. Thus adenosine protects against loss of coronary flow reserve and regional myocardial function in dogs subjected to coronary artery occlusion and reperfusion. SN - 0002-8703 UR - https://www.unboundmedicine.com/medline/citation/8172047/Adenosine_protects_against_attenuation_of_flow_reserve_and_myocardial_function_after_coronary_occlusion_and_reperfusion_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0002-8703(94)90037-X DB - PRIME DP - Unbound Medicine ER -