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Delayed gastric emptying of both the liquid and solid components of a meal in chronic liver disease.
Am J Gastroenterol. 1994 May; 89(5):708-11.AJ

Abstract

OBJECTIVES

To evaluate gastric emptying in patients with chronic liver disease and portal hypertension.

METHODS

We measured gastric emptying of both the liquid and solid components of a meal in 10 consecutive patients with chronic liver disease and portal hypertension, but free of ascites, and 14 age- and sex-matched healthy controls. In the patients with liver disease, relationships between emptying and liver function were examined. To measure gastric emptying, subjects consumed a test meal that consisted of scrambled eggs labeled with 99mTc-sulfur colloid and 4 oz of water labeled with 111In-diethylene triamine pentacetic acid (DTPA).

RESULTS

Patients with liver disease and portal hypertension demonstrated delayed emptying of both the liquid (t1/2, min, mean +/- SE, patients vs.

CONTROLS

69.4 +/- 19.4 vs. 31.4 +/- 1.8, p < 0.01) and solid (post-lag phase solid emptying: 141 +/- 32.9 vs. 69.8 +/- 4.6, p < 0.006) components of the meal. We could not identify any correlation between gastric emptying and tests of liver function.

CONCLUSIONS

Gastric emptying is delayed in patients with liver disease and portal hypertension; this abnormal gastric motor function may contribute to the pathophysiology of foregut complaints in this patient population.

Authors+Show Affiliations

Galati JS
Department of Internal Medicine, University of Nebraska Medical Center, Omaha.
Holdeman KP
No affiliation info available
Dalrymple GV
No affiliation info available
Harrison KA
No affiliation info available
Quigley EM
No affiliation info available

MeSH

AdultChronic DiseaseFemaleFoodGastric EmptyingHumansHypertension, PortalIndium RadioisotopesLiver DiseasesLiver Function TestsMaleMiddle AgedPentetic AcidTechnetium Tc 99m Sulfur Colloid

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8172142

Citation

Galati, J S., et al. "Delayed Gastric Emptying of Both the Liquid and Solid Components of a Meal in Chronic Liver Disease." The American Journal of Gastroenterology, vol. 89, no. 5, 1994, pp. 708-11.
Galati JS, Holdeman KP, Dalrymple GV, et al. Delayed gastric emptying of both the liquid and solid components of a meal in chronic liver disease. Am J Gastroenterol. 1994;89(5):708-11.
Galati, J. S., Holdeman, K. P., Dalrymple, G. V., Harrison, K. A., & Quigley, E. M. (1994). Delayed gastric emptying of both the liquid and solid components of a meal in chronic liver disease. The American Journal of Gastroenterology, 89(5), 708-11.
Galati JS, et al. Delayed Gastric Emptying of Both the Liquid and Solid Components of a Meal in Chronic Liver Disease. Am J Gastroenterol. 1994;89(5):708-11. PubMed PMID: 8172142.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Delayed gastric emptying of both the liquid and solid components of a meal in chronic liver disease. AU - Galati,J S, AU - Holdeman,K P, AU - Dalrymple,G V, AU - Harrison,K A, AU - Quigley,E M, PY - 1994/5/1/pubmed PY - 1994/5/1/medline PY - 1994/5/1/entrez SP - 708 EP - 11 JF - The American journal of gastroenterology JO - Am J Gastroenterol VL - 89 IS - 5 N2 - OBJECTIVES: To evaluate gastric emptying in patients with chronic liver disease and portal hypertension. METHODS: We measured gastric emptying of both the liquid and solid components of a meal in 10 consecutive patients with chronic liver disease and portal hypertension, but free of ascites, and 14 age- and sex-matched healthy controls. In the patients with liver disease, relationships between emptying and liver function were examined. To measure gastric emptying, subjects consumed a test meal that consisted of scrambled eggs labeled with 99mTc-sulfur colloid and 4 oz of water labeled with 111In-diethylene triamine pentacetic acid (DTPA). RESULTS: Patients with liver disease and portal hypertension demonstrated delayed emptying of both the liquid (t1/2, min, mean +/- SE, patients vs. CONTROLS: 69.4 +/- 19.4 vs. 31.4 +/- 1.8, p < 0.01) and solid (post-lag phase solid emptying: 141 +/- 32.9 vs. 69.8 +/- 4.6, p < 0.006) components of the meal. We could not identify any correlation between gastric emptying and tests of liver function. CONCLUSIONS: Gastric emptying is delayed in patients with liver disease and portal hypertension; this abnormal gastric motor function may contribute to the pathophysiology of foregut complaints in this patient population. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/8172142/Delayed_gastric_emptying_of_both_the_liquid_and_solid_components_of_a_meal_in_chronic_liver_disease_ L2 - http://www.diseaseinfosearch.org/result/4280 DB - PRIME DP - Unbound Medicine ER -