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Effect of inhaled PGE2 on exercise-induced bronchoconstriction in asthmatic subjects.
Am J Respir Crit Care Med. 1994 May; 149(5):1138-41.AJ

Abstract

Previous studies have suggested that the endogenous release of inhibitory prostanoids limits the bronchoconstrictor response to repeated exercise. The aim of our study was to determine whether inhaled prostaglandin (PG)E2 attenuates exercise-induced bronchoconstriction or methacholine airway responsiveness in asthmatic subjects. Eight subjects with mild stable asthma and exercise bronchoconstriction were studied on 4 separate days, 48 h apart. Subjects inhaled PGE2 or placebo in a randomized, crossover, double-blind fashion, 30 min prior to an exercise challenge or a methacholine challenge. PGE2 inhalation significantly attenuated exercise bronchoconstriction. The mean maximal %fall in FEV1 after exercise was 26% (SEM 3.7%) after placebo, and was 9.7% (SEM 2.7%) after PGE2 (p < 0.001). PGE2 also significantly reduced the duration of exercise bronchoconstriction (p = 0.034). However, PGE2 did not significantly attenuate methacholine airway responsiveness. The geometric mean methacholine provocative concentration causing a 20% fall in FEV1 (PC20) was 0.77 (%SEM 1.48) after placebo day, and 1.41 (%SEM 2.20) after PGE2 (p = 0.30). These results demonstrate that inhaled PGE2 markedly attenuates exercise bronchoconstriction in asthmatic subjects and suggest that this effect is not occurring through functional antagonism of airway smooth muscle.

Authors+Show Affiliations

Department of Medicine, McMaster University, Hamilton, Ontario, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8173753

Citation

Melillo, E, et al. "Effect of Inhaled PGE2 On Exercise-induced Bronchoconstriction in Asthmatic Subjects." American Journal of Respiratory and Critical Care Medicine, vol. 149, no. 5, 1994, pp. 1138-41.
Melillo E, Woolley KL, Manning PJ, et al. Effect of inhaled PGE2 on exercise-induced bronchoconstriction in asthmatic subjects. Am J Respir Crit Care Med. 1994;149(5):1138-41.
Melillo, E., Woolley, K. L., Manning, P. J., Watson, R. M., & O'Byrne, P. M. (1994). Effect of inhaled PGE2 on exercise-induced bronchoconstriction in asthmatic subjects. American Journal of Respiratory and Critical Care Medicine, 149(5), 1138-41.
Melillo E, et al. Effect of Inhaled PGE2 On Exercise-induced Bronchoconstriction in Asthmatic Subjects. Am J Respir Crit Care Med. 1994;149(5):1138-41. PubMed PMID: 8173753.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of inhaled PGE2 on exercise-induced bronchoconstriction in asthmatic subjects. AU - Melillo,E, AU - Woolley,K L, AU - Manning,P J, AU - Watson,R M, AU - O'Byrne,P M, PY - 1994/5/1/pubmed PY - 1994/5/1/medline PY - 1994/5/1/entrez SP - 1138 EP - 41 JF - American journal of respiratory and critical care medicine JO - Am J Respir Crit Care Med VL - 149 IS - 5 N2 - Previous studies have suggested that the endogenous release of inhibitory prostanoids limits the bronchoconstrictor response to repeated exercise. The aim of our study was to determine whether inhaled prostaglandin (PG)E2 attenuates exercise-induced bronchoconstriction or methacholine airway responsiveness in asthmatic subjects. Eight subjects with mild stable asthma and exercise bronchoconstriction were studied on 4 separate days, 48 h apart. Subjects inhaled PGE2 or placebo in a randomized, crossover, double-blind fashion, 30 min prior to an exercise challenge or a methacholine challenge. PGE2 inhalation significantly attenuated exercise bronchoconstriction. The mean maximal %fall in FEV1 after exercise was 26% (SEM 3.7%) after placebo, and was 9.7% (SEM 2.7%) after PGE2 (p < 0.001). PGE2 also significantly reduced the duration of exercise bronchoconstriction (p = 0.034). However, PGE2 did not significantly attenuate methacholine airway responsiveness. The geometric mean methacholine provocative concentration causing a 20% fall in FEV1 (PC20) was 0.77 (%SEM 1.48) after placebo day, and 1.41 (%SEM 2.20) after PGE2 (p = 0.30). These results demonstrate that inhaled PGE2 markedly attenuates exercise bronchoconstriction in asthmatic subjects and suggest that this effect is not occurring through functional antagonism of airway smooth muscle. SN - 1073-449X UR - https://www.unboundmedicine.com/medline/citation/8173753/Effect_of_inhaled_PGE2_on_exercise_induced_bronchoconstriction_in_asthmatic_subjects_ L2 - https://www.atsjournals.org/doi/10.1164/ajrccm.149.5.8173753?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -