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The detection, transmission, and outcome of hepatitis C virus infection.
Infect Agents Dis 1993; 2(3):155-66IA

Abstract

Hepatitis C virus (HCV), the primary etiologic agent of parenterally transmitted non-A, non-B hepatitis, is a major cause of acute and chronic hepatitis and cirrhosis worldwide. The most efficient transmission of HCV is associated with percutaneous exposures to blood, but such exposures account for less than half of reported cases. Sexual, household, and perinatal transmission also seem to occur, but the risks associated with these types of exposures are still unknown. Virtually all persons with acute HCV infection seem to become chronically infected, and chronic liver disease with persistently elevated liver enzymes develops in an average of 67%, independent of the source for infection. The extraordinarily high rate of persistent infection observed in humans and the lack of protection against rechallenge with homologous HCV strains demonstrated in experimental studies in chimpanzees suggest that HCV fails to induce an effective neutralizing antibody response. This raises major concerns for the development of effective passive or active immunization against hepatitis C, and prevention may depend on a better understanding of the factors that facilitate the transmission of HCV infection.

Authors+Show Affiliations

Hepatitis Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

8173786

Citation

Alter, M J.. "The Detection, Transmission, and Outcome of Hepatitis C Virus Infection." Infectious Agents and Disease, vol. 2, no. 3, 1993, pp. 155-66.
Alter MJ. The detection, transmission, and outcome of hepatitis C virus infection. Infect Agents Dis. 1993;2(3):155-66.
Alter, M. J. (1993). The detection, transmission, and outcome of hepatitis C virus infection. Infectious Agents and Disease, 2(3), pp. 155-66.
Alter MJ. The Detection, Transmission, and Outcome of Hepatitis C Virus Infection. Infect Agents Dis. 1993;2(3):155-66. PubMed PMID: 8173786.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The detection, transmission, and outcome of hepatitis C virus infection. A1 - Alter,M J, PY - 1993/6/1/pubmed PY - 1993/6/1/medline PY - 1993/6/1/entrez SP - 155 EP - 66 JF - Infectious agents and disease JO - Infect Agents Dis VL - 2 IS - 3 N2 - Hepatitis C virus (HCV), the primary etiologic agent of parenterally transmitted non-A, non-B hepatitis, is a major cause of acute and chronic hepatitis and cirrhosis worldwide. The most efficient transmission of HCV is associated with percutaneous exposures to blood, but such exposures account for less than half of reported cases. Sexual, household, and perinatal transmission also seem to occur, but the risks associated with these types of exposures are still unknown. Virtually all persons with acute HCV infection seem to become chronically infected, and chronic liver disease with persistently elevated liver enzymes develops in an average of 67%, independent of the source for infection. The extraordinarily high rate of persistent infection observed in humans and the lack of protection against rechallenge with homologous HCV strains demonstrated in experimental studies in chimpanzees suggest that HCV fails to induce an effective neutralizing antibody response. This raises major concerns for the development of effective passive or active immunization against hepatitis C, and prevention may depend on a better understanding of the factors that facilitate the transmission of HCV infection. SN - 1056-2044 UR - https://www.unboundmedicine.com/medline/citation/8173786/The_detection_transmission_and_outcome_of_hepatitis_C_virus_infection_ L2 - http://www.diseaseinfosearch.org/result/3332 DB - PRIME DP - Unbound Medicine ER -