Tags

Type your tag names separated by a space and hit enter

Central role of zinc protoporphyrin in staging iron deficiency.
Clin Chem. 1994 May; 40(5):768-73.CC

Abstract

In iron deficiency, zinc protoporphyrin (ZPP) is produced instead of heme, and the ZPP concentration in erythrocytes is increased (normal < or = 40 mumol/mol heme). We investigated the relevance of ZPP for staging iron deficiency. ZPP was determined by hematofluorometry in samples from 103 patients. Nineteen patients with iron depletion showed decreased serum ferritin (12.1 +/- 4.4 micrograms/L) with normal ZPP and hemoglobin (Hb). Twelve patients with iron-deficient erythropoiesis had decreased ferritin (10.4 +/- 2.4 micrograms/L), increased ZPP (72 +/- 9 mumol/mol heme), and normal Hb concentrations. In 72 patients with iron-deficiency anemia, ferritin was < 12 micrograms/L. In mild anemia (Hb between 100 and 120 g/L, and normal erythrocyte indices), ZPP was 100 +/- 16 mumol/mol heme. In severe anemia (Hb < 100 g/L, decreased erythrocyte indices), ZPP values were significantly higher (265 +/- 109 mumol/mol heme). We conclude that measurements of ZPP, ferritin, and Hb can reliably be combined to classify the degree of iron deficiency.

Authors+Show Affiliations

III, Medizinische Klinik Mannheim, Universität Heidelberg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8174250

Citation

Hastka, J, et al. "Central Role of Zinc Protoporphyrin in Staging Iron Deficiency." Clinical Chemistry, vol. 40, no. 5, 1994, pp. 768-73.
Hastka J, Lasserre JJ, Schwarzbeck A, et al. Central role of zinc protoporphyrin in staging iron deficiency. Clin Chem. 1994;40(5):768-73.
Hastka, J., Lasserre, J. J., Schwarzbeck, A., & Hehlmann, R. (1994). Central role of zinc protoporphyrin in staging iron deficiency. Clinical Chemistry, 40(5), 768-73.
Hastka J, et al. Central Role of Zinc Protoporphyrin in Staging Iron Deficiency. Clin Chem. 1994;40(5):768-73. PubMed PMID: 8174250.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Central role of zinc protoporphyrin in staging iron deficiency. AU - Hastka,J, AU - Lasserre,J J, AU - Schwarzbeck,A, AU - Hehlmann,R, PY - 1994/5/1/pubmed PY - 1994/5/1/medline PY - 1994/5/1/entrez SP - 768 EP - 73 JF - Clinical chemistry JO - Clin Chem VL - 40 IS - 5 N2 - In iron deficiency, zinc protoporphyrin (ZPP) is produced instead of heme, and the ZPP concentration in erythrocytes is increased (normal < or = 40 mumol/mol heme). We investigated the relevance of ZPP for staging iron deficiency. ZPP was determined by hematofluorometry in samples from 103 patients. Nineteen patients with iron depletion showed decreased serum ferritin (12.1 +/- 4.4 micrograms/L) with normal ZPP and hemoglobin (Hb). Twelve patients with iron-deficient erythropoiesis had decreased ferritin (10.4 +/- 2.4 micrograms/L), increased ZPP (72 +/- 9 mumol/mol heme), and normal Hb concentrations. In 72 patients with iron-deficiency anemia, ferritin was < 12 micrograms/L. In mild anemia (Hb between 100 and 120 g/L, and normal erythrocyte indices), ZPP was 100 +/- 16 mumol/mol heme. In severe anemia (Hb < 100 g/L, decreased erythrocyte indices), ZPP values were significantly higher (265 +/- 109 mumol/mol heme). We conclude that measurements of ZPP, ferritin, and Hb can reliably be combined to classify the degree of iron deficiency. SN - 0009-9147 UR - https://www.unboundmedicine.com/medline/citation/8174250/Central_role_of_zinc_protoporphyrin_in_staging_iron_deficiency_ L2 - https://medlineplus.gov/iron.html DB - PRIME DP - Unbound Medicine ER -