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Wernicke's encephalopathy in hyperemesis gravidarum: association with abnormal liver function.
Isr J Med Sci. 1994 Mar; 30(3):225-8.IJ

Abstract

A 27-year-old woman developed Wernicke's encephalopathy in the 18th week of her pregnancy after 11 weeks of vomiting accompanied by weight loss of 21 kg and moderately abnormal liver function tests. The patient recovered after thiamine therapy but the fetus was lost. Review of the literature published during the last 25 years revealed an additional 14 cases of Wernicke's encephalopathy complicating hyperemesis gravidarum. All patients vomited for at least 4 weeks. Six of the 15 patients (40%) had aspartate aminotransferase values > 100 U/l, much higher than the rate reported in previous series of patients with hyperemesis gravidarum (7%). This suggests the need for parenteral thiamine supplementation in patients with severe hyperemesis gravidarum lasting more than 3 weeks, especially those with abnormal liver function, and supports the hypothesis that the hepatic abnormality plays a pathogenetic role in the development of Wernicke's encephalopathy in hyperemesis gravidarum.

Authors+Show Affiliations

Rotman P
Department of Medicine E, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
Hassin D
No affiliation info available
Mouallem M
No affiliation info available
Barkai G
No affiliation info available
Farfel Z
No affiliation info available

MeSH

AdultAspartate AminotransferasesFemaleHumansHyperemesis GravidarumLiver Function TestsPregnancyThiamineWernicke Encephalopathy

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

8181922

Citation

Rotman, P, et al. "Wernicke's Encephalopathy in Hyperemesis Gravidarum: Association With Abnormal Liver Function." Israel Journal of Medical Sciences, vol. 30, no. 3, 1994, pp. 225-8.
Rotman P, Hassin D, Mouallem M, et al. Wernicke's encephalopathy in hyperemesis gravidarum: association with abnormal liver function. Isr J Med Sci. 1994;30(3):225-8.
Rotman, P., Hassin, D., Mouallem, M., Barkai, G., & Farfel, Z. (1994). Wernicke's encephalopathy in hyperemesis gravidarum: association with abnormal liver function. Israel Journal of Medical Sciences, 30(3), 225-8.
Rotman P, et al. Wernicke's Encephalopathy in Hyperemesis Gravidarum: Association With Abnormal Liver Function. Isr J Med Sci. 1994;30(3):225-8. PubMed PMID: 8181922.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Wernicke's encephalopathy in hyperemesis gravidarum: association with abnormal liver function. AU - Rotman,P, AU - Hassin,D, AU - Mouallem,M, AU - Barkai,G, AU - Farfel,Z, PY - 1994/3/1/pubmed PY - 1994/3/1/medline PY - 1994/3/1/entrez SP - 225 EP - 8 JF - Israel journal of medical sciences JO - Isr J Med Sci VL - 30 IS - 3 N2 - A 27-year-old woman developed Wernicke's encephalopathy in the 18th week of her pregnancy after 11 weeks of vomiting accompanied by weight loss of 21 kg and moderately abnormal liver function tests. The patient recovered after thiamine therapy but the fetus was lost. Review of the literature published during the last 25 years revealed an additional 14 cases of Wernicke's encephalopathy complicating hyperemesis gravidarum. All patients vomited for at least 4 weeks. Six of the 15 patients (40%) had aspartate aminotransferase values > 100 U/l, much higher than the rate reported in previous series of patients with hyperemesis gravidarum (7%). This suggests the need for parenteral thiamine supplementation in patients with severe hyperemesis gravidarum lasting more than 3 weeks, especially those with abnormal liver function, and supports the hypothesis that the hepatic abnormality plays a pathogenetic role in the development of Wernicke's encephalopathy in hyperemesis gravidarum. SN - 0021-2180 UR - https://www.unboundmedicine.com/medline/citation/8181922/Wernicke's_encephalopathy_in_hyperemesis_gravidarum:_association_with_abnormal_liver_function_ DB - PRIME DP - Unbound Medicine ER -