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The association of HL-A B27 with Forestier's disease (vertebral ankylosing hyperostosis).
J Rheumatol. 1976 Mar; 3(1):4-8.JR

Abstract

Despite the lack of apophyseal or sacroiliac joint involvement, Forestier's disease (vertebral ankylosing hyperostosis) shares with the inflammatory forms of spondylitis, the roentgenographic appearance of spinal new bone formation. Because of this apparent similarity, the prevalence of the HL-A B27 antigen was determined in 47 white patients with Forestier's disease. Sixteen of the patients (34 per cent) possessed the B27 antigen (P is less than 0.001). The mere presence of B27 therefore, does not confirm the diagnosis of inflammatory spondylitis in all patients with roentgenographic evidence of osseous bridging. Applying available epidemiologic information, these data further suggest that patients with the B27 antigen may be at substantial risk of developing Forestier's disease. As Forestier's disease and virtually all of the other B27 associated arthropathies manifest abundant new bone, an association may exist between this antigen and genes controlling new bone formation.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

818379

Citation

Shapiro, R F., et al. "The Association of HL-A B27 With Forestier's Disease (vertebral Ankylosing Hyperostosis)." The Journal of Rheumatology, vol. 3, no. 1, 1976, pp. 4-8.
Shapiro RF, Utsinger PD, Wiesner KB, et al. The association of HL-A B27 with Forestier's disease (vertebral ankylosing hyperostosis). J Rheumatol. 1976;3(1):4-8.
Shapiro, R. F., Utsinger, P. D., Wiesner, K. B., Resnick, D., Bryan, B. L., & Castles, J. L. (1976). The association of HL-A B27 with Forestier's disease (vertebral ankylosing hyperostosis). The Journal of Rheumatology, 3(1), 4-8.
Shapiro RF, et al. The Association of HL-A B27 With Forestier's Disease (vertebral Ankylosing Hyperostosis). J Rheumatol. 1976;3(1):4-8. PubMed PMID: 818379.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association of HL-A B27 with Forestier's disease (vertebral ankylosing hyperostosis). AU - Shapiro,R F, AU - Utsinger,P D, AU - Wiesner,K B, AU - Resnick,D, AU - Bryan,B L, AU - Castles,J L, PY - 1976/3/1/pubmed PY - 1976/3/1/medline PY - 1976/3/1/entrez SP - 4 EP - 8 JF - The Journal of rheumatology JO - J Rheumatol VL - 3 IS - 1 N2 - Despite the lack of apophyseal or sacroiliac joint involvement, Forestier's disease (vertebral ankylosing hyperostosis) shares with the inflammatory forms of spondylitis, the roentgenographic appearance of spinal new bone formation. Because of this apparent similarity, the prevalence of the HL-A B27 antigen was determined in 47 white patients with Forestier's disease. Sixteen of the patients (34 per cent) possessed the B27 antigen (P is less than 0.001). The mere presence of B27 therefore, does not confirm the diagnosis of inflammatory spondylitis in all patients with roentgenographic evidence of osseous bridging. Applying available epidemiologic information, these data further suggest that patients with the B27 antigen may be at substantial risk of developing Forestier's disease. As Forestier's disease and virtually all of the other B27 associated arthropathies manifest abundant new bone, an association may exist between this antigen and genes controlling new bone formation. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/818379/The_association_of_HL_A_B27_with_Forestier's_disease__vertebral_ankylosing_hyperostosis__ L2 - https://antibodies.cancer.gov/detail/CPTC-HLA-DPB1-2 DB - PRIME DP - Unbound Medicine ER -