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[The endocrine pancreas. From the isolated islet to the "artificial pancreas" (author's transl)].
MMW Munch Med Wochenschr. 1976 Apr 16; 118(16):485-92.MM

Abstract

The endocrine function of the pancreas consists of the promotion of storage of nutritive substances after meals through the liberation of insulin and to guarantee the mobilization of this food energy through the secretion of glucagon during fasting. Increased hormone production may result from tumors of the islet cells (insulin: insulinoma; glucagon: glucagonoma; gastrin: Zollinger-Ellison syndrome). An absolute or relative insulin deficiency is a characteristic of diabetes mellitus, in which a relative hyperglucagonemia is also of possible pathophysiological significance. This increased secretion of glucagon can be suppressed by somatostatin. While the clinical application of somatostatin in diabetes mellitus seems problematic at present, the use of a glucose-controlled system of insulin infusion ("artificial pancreas") makes possible a metabolic state approaching the healthy condition.

Authors

Schatz H
No affiliation info available
Pfeiffer EF
No affiliation info available

MeSH

AdultArtificial OrgansAutomationBlood GlucoseDiabetes MellitusFemaleGlucagonGlucoseGlucose Tolerance TestHumansHungerInsulinIslets of LangerhansMaleMiddle AgedPancreas

Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

818514

Citation

Schatz, H, and E F. Pfeiffer. "[The Endocrine Pancreas. From the Isolated Islet to the "artificial Pancreas" (author's Transl)]." MMW, Munchener Medizinische Wochenschrift, vol. 118, no. 16, 1976, pp. 485-92.
Schatz H, Pfeiffer EF. [The endocrine pancreas. From the isolated islet to the "artificial pancreas" (author's transl)]. MMW Munch Med Wochenschr. 1976;118(16):485-92.
Schatz, H., & Pfeiffer, E. F. (1976). [The endocrine pancreas. From the isolated islet to the "artificial pancreas" (author's transl)]. MMW, Munchener Medizinische Wochenschrift, 118(16), 485-92.
Schatz H, Pfeiffer EF. [The Endocrine Pancreas. From the Isolated Islet to the "artificial Pancreas" (author's Transl)]. MMW Munch Med Wochenschr. 1976 Apr 16;118(16):485-92. PubMed PMID: 818514.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The endocrine pancreas. From the isolated islet to the "artificial pancreas" (author's transl)]. AU - Schatz,H, AU - Pfeiffer,E F, PY - 1976/4/16/pubmed PY - 1976/4/16/medline PY - 1976/4/16/entrez SP - 485 EP - 92 JF - MMW, Munchener medizinische Wochenschrift JO - MMW Munch Med Wochenschr VL - 118 IS - 16 N2 - The endocrine function of the pancreas consists of the promotion of storage of nutritive substances after meals through the liberation of insulin and to guarantee the mobilization of this food energy through the secretion of glucagon during fasting. Increased hormone production may result from tumors of the islet cells (insulin: insulinoma; glucagon: glucagonoma; gastrin: Zollinger-Ellison syndrome). An absolute or relative insulin deficiency is a characteristic of diabetes mellitus, in which a relative hyperglucagonemia is also of possible pathophysiological significance. This increased secretion of glucagon can be suppressed by somatostatin. While the clinical application of somatostatin in diabetes mellitus seems problematic at present, the use of a glucose-controlled system of insulin infusion ("artificial pancreas") makes possible a metabolic state approaching the healthy condition. SN - 0341-3098 UR - https://www.unboundmedicine.com/medline/citation/818514/[The_endocrine_pancreas__From_the_isolated_islet_to_the_"artificial_pancreas"__author's_transl_]_ DB - PRIME DP - Unbound Medicine ER -