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Response of falciparum malaria to chloroquine and three second line antimalarial drugs in a Kenyan coastal school age population.
East Afr Med J. 1993 Oct; 70(10):620-3.EA

Abstract

Ambulatory rural school children in the Mombasa area with P. falciparum parasitaemia were examined and randomly assigned to treatment with one of three second-line antimalarials--amodiaquine, pyrimethamine/sulphadoxine (P/SD) and pyrimethamine/sulfalene (P/SL). Clinical signs and parasitaemia were followed daily for the first week and on days 14 and 28. WHO Mark II schizont inhibition tests were performed for all the above 3 drugs and chloroquine. The total number of cases was 73. The mean parasite density was 142.1 +/- 207; 102.7 +/- 166; 82.74 +/- 93 parasites per 300 WBC for amodiaquine, P/SD, and P/SL, respectively. In vitro tests showed a chloroquine resistance rate of 60% and no resistance to all of the second line drugs. Also, all children treated successfully cleared their parasitaemia with mean clearance rates of 2.05 +/- 0.57; 1.86 +/- 0.47; 2.05 +/- 0.50 days for amodiaquine, P/SD and P/SL, respectively. Even though, no difference in the effectiveness between the second line drugs used was found, reinfection rates as depicted by day 28 parasitaemia differed--amodiaquine 16%; P/SD 0%; and P/SL4.35%. This difference could be attributed to the difference in the pharmacokinetic properties of the drugs.

Authors+Show Affiliations

Department of Pharmacy, University of Nairobi, Kenya.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

8187656

Citation

Hagos, B, et al. "Response of Falciparum Malaria to Chloroquine and Three Second Line Antimalarial Drugs in a Kenyan Coastal School Age Population." East African Medical Journal, vol. 70, no. 10, 1993, pp. 620-3.
Hagos B, Khan B, Ofulla AV, et al. Response of falciparum malaria to chloroquine and three second line antimalarial drugs in a Kenyan coastal school age population. East Afr Med J. 1993;70(10):620-3.
Hagos, B., Khan, B., Ofulla, A. V., Kariuki, D., & Martin, S. K. (1993). Response of falciparum malaria to chloroquine and three second line antimalarial drugs in a Kenyan coastal school age population. East African Medical Journal, 70(10), 620-3.
Hagos B, et al. Response of Falciparum Malaria to Chloroquine and Three Second Line Antimalarial Drugs in a Kenyan Coastal School Age Population. East Afr Med J. 1993;70(10):620-3. PubMed PMID: 8187656.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Response of falciparum malaria to chloroquine and three second line antimalarial drugs in a Kenyan coastal school age population. AU - Hagos,B, AU - Khan,B, AU - Ofulla,A V, AU - Kariuki,D, AU - Martin,S K, PY - 1993/10/1/pubmed PY - 1993/10/1/medline PY - 1993/10/1/entrez KW - Africa KW - Africa South Of The Sahara KW - Age Factors KW - Child KW - Clinical Research KW - Comparative Studies KW - Demographic Factors KW - Developing Countries KW - Diseases KW - Drugs KW - Eastern Africa KW - English Speaking Africa KW - Kenya KW - Malaria KW - Parasitic Diseases KW - Population KW - Population Characteristics KW - Research Methodology KW - Research Report KW - School Age Population KW - Studies KW - Treatment KW - Youth SP - 620 EP - 3 JF - East African medical journal JO - East Afr Med J VL - 70 IS - 10 N2 - Ambulatory rural school children in the Mombasa area with P. falciparum parasitaemia were examined and randomly assigned to treatment with one of three second-line antimalarials--amodiaquine, pyrimethamine/sulphadoxine (P/SD) and pyrimethamine/sulfalene (P/SL). Clinical signs and parasitaemia were followed daily for the first week and on days 14 and 28. WHO Mark II schizont inhibition tests were performed for all the above 3 drugs and chloroquine. The total number of cases was 73. The mean parasite density was 142.1 +/- 207; 102.7 +/- 166; 82.74 +/- 93 parasites per 300 WBC for amodiaquine, P/SD, and P/SL, respectively. In vitro tests showed a chloroquine resistance rate of 60% and no resistance to all of the second line drugs. Also, all children treated successfully cleared their parasitaemia with mean clearance rates of 2.05 +/- 0.57; 1.86 +/- 0.47; 2.05 +/- 0.50 days for amodiaquine, P/SD and P/SL, respectively. Even though, no difference in the effectiveness between the second line drugs used was found, reinfection rates as depicted by day 28 parasitaemia differed--amodiaquine 16%; P/SD 0%; and P/SL4.35%. This difference could be attributed to the difference in the pharmacokinetic properties of the drugs. SN - 0012-835X UR - https://www.unboundmedicine.com/medline/citation/8187656/Response_of_falciparum_malaria_to_chloroquine_and_three_second_line_antimalarial_drugs_in_a_Kenyan_coastal_school_age_population_ DB - PRIME DP - Unbound Medicine ER -