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Electron microscopic observations of the relationship between peripheral nerve tissue proper and an endoneurial capillary in a dermal lesion of relapsed lepromatous patient.
Int J Lepr Other Mycobact Dis. 1994 Mar; 62(1):89-98.IJ

Abstract

The origin of relapse in clinically cured leprosy patients and the dissemination of Mycobacterium leprae in such patients are hitherto little understood phenomena. A detailed electron microscopical examination of a small dermal nerve in a lepromatous lesion of a presently relapsed patient was carried out. Our observations showed the presence of M. leprae in Schwann cells, perineurial cells, vacuolar spaces located in axoplasm and elsewhere. The course of a capillary, entering the endoneurium from the epineurium via the perineurium, suggested the possibility of hematogenous spread of M. leprae which had been tucked away in the dermal peripheral nerve. At the time of relapse, bacilli may multiply in the nerve, may enter the bloodstream, and thus disseminate from the nerve into other nerves and other tissues via hematogenous spread.

Authors+Show Affiliations

Research and Training Section, National Institute for Leprosy Research, Tokyo, Japan.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8189092

Citation

Hirata, T, and N Harada. "Electron Microscopic Observations of the Relationship Between Peripheral Nerve Tissue Proper and an Endoneurial Capillary in a Dermal Lesion of Relapsed Lepromatous Patient." International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, vol. 62, no. 1, 1994, pp. 89-98.
Hirata T, Harada N. Electron microscopic observations of the relationship between peripheral nerve tissue proper and an endoneurial capillary in a dermal lesion of relapsed lepromatous patient. Int J Lepr Other Mycobact Dis. 1994;62(1):89-98.
Hirata, T., & Harada, N. (1994). Electron microscopic observations of the relationship between peripheral nerve tissue proper and an endoneurial capillary in a dermal lesion of relapsed lepromatous patient. International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, 62(1), 89-98.
Hirata T, Harada N. Electron Microscopic Observations of the Relationship Between Peripheral Nerve Tissue Proper and an Endoneurial Capillary in a Dermal Lesion of Relapsed Lepromatous Patient. Int J Lepr Other Mycobact Dis. 1994;62(1):89-98. PubMed PMID: 8189092.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Electron microscopic observations of the relationship between peripheral nerve tissue proper and an endoneurial capillary in a dermal lesion of relapsed lepromatous patient. AU - Hirata,T, AU - Harada,N, PY - 1994/3/1/pubmed PY - 1994/3/1/medline PY - 1994/3/1/entrez SP - 89 EP - 98 JF - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association JO - Int J Lepr Other Mycobact Dis VL - 62 IS - 1 N2 - The origin of relapse in clinically cured leprosy patients and the dissemination of Mycobacterium leprae in such patients are hitherto little understood phenomena. A detailed electron microscopical examination of a small dermal nerve in a lepromatous lesion of a presently relapsed patient was carried out. Our observations showed the presence of M. leprae in Schwann cells, perineurial cells, vacuolar spaces located in axoplasm and elsewhere. The course of a capillary, entering the endoneurium from the epineurium via the perineurium, suggested the possibility of hematogenous spread of M. leprae which had been tucked away in the dermal peripheral nerve. At the time of relapse, bacilli may multiply in the nerve, may enter the bloodstream, and thus disseminate from the nerve into other nerves and other tissues via hematogenous spread. SN - 0148-916X UR - https://www.unboundmedicine.com/medline/citation/8189092/Electron_microscopic_observations_of_the_relationship_between_peripheral_nerve_tissue_proper_and_an_endoneurial_capillary_in_a_dermal_lesion_of_relapsed_lepromatous_patient_ DB - PRIME DP - Unbound Medicine ER -
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